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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Volume of fluid (VOF) method for the dynamics of free boundaries显示文摘 | Hirt C W Nichols B D | 1981 | Journal of Computational Physics1981，39，： | 2 |
| 3 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 4 | Formation of pluripotent stem cells in the mammalian embryo dependson the POU transcription factor Oct4显示文摘 | Nichols J Zevnik B Anastassiadis K | 1998 | Cell1998，95，： | 1 |
| 5 | Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32显示文摘 | Nichols WC Koller DL Slovis B | 1997 | Nat Genct1997，15，3： | 1 |
| 6 | Assessment of BLS skills, Optimizing use of instructor and manikin measures显示文摘 | LYNCH B EINSPRUCH E L NICHOL G | 2008 | Resuscitation2008，76，2： | 1 |
| 7 | Volume of fluid (VOF) method for the dynamics of free boundaries 显示文摘 | HIRT C W NICHOLS B D | 1981 | J Comput Phys1981，39，： | 1 |
| 8 | Pharmacodynamics and pharmacokinetics of AMG-531, a novel thrombopoietin receptor ligand 显示文摘 | Wang B Nichol J L Sullivan J T | 2004 | Clin Pharm Ther2004，76，6： | 1 |
| 9 | Volume of fluid (VOF) Method for the dynamics of free boundaries显示文摘 | Nichols B D | 1981 | Journal of Computational Physics1981，39，1： | 1 |
| 10 | Volume of Fluid (VOF) Method for the Dynamics of Free Boundary显示文摘 | Hirt C W Nichols B D | 1981 | Journal of Computational Physics1981，，39： | 1 |
| 11 | Patient-controlled sedation forelderly patients: safety and patient attitude toward control 显示文摘 | Herrick IA Gelb AW Nichols B | 2008 | Can J Anaesth2008，43，： | 1 |
| 12 | Intermittent Detonation as a ThrustProducing Mechanism 显示文摘 | Nicholl J A Wilkinson H R Morrison R B | 1957 | Jet Propulsion1957，27，： | 1 |
| 13 | Using collaborative filtering to weave an information tapestry显示文摘 | Goldberg D Nichols D Oki B M | 1992 | Communications of the Association for Computing Machinery1992，35，12： | 1 |
| 14 | Haemorrhoids: pathology, pathophysiology and aetiology显示文摘 | Loder P B Kamm M A Nicholls R J | 1994 | Br J Surg1994，81，7： | 1 |
| 15 | Effectiveness of a 30-min CPR self-instruction program for lay responders: a controlled randomized study显示文摘 | LYNCH B EINSPRUCH E L NICHOL G | 2005 | Resuscitation2005，67，1： | 1 |
| 16 | Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4显示文摘 | Nichols J Zevnik B Anastassiadis K | 1998 | Cell1998，95，： | 1 |
| 17 | Volume of Fluid (VOF) Method for the Dynamics of Free Boundaries显示文摘 | Hirt C W Nichols B D | 1981 | J Comput Phys1981，39，1： | 1 |
| 18 | Volume of Fluid (VOF) method for the dynamics of free boundaries显示文摘 | Hirt C W Nichols B D | 1981 | Journal of Computational Physics1981，39，： | 1 |
| 19 | Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 显示文摘 | Nichols J Zevnik B Anastassiadis K | 1998 | Cell1998，95，： | 1 |
| 20 | Volume of fluid (VOF)method for the dynamics of free boundaries 显示文摘 | HIRT C W NICHOLS B D | 1981 | J Comput Phys1981，39，： | 1 |
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