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| 1 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 2 | Impact of complex geneticvariation in COMT on human brain function显示文摘 | Meyer-Lindenberg A Nichols T Callicott JH | 2006 | Mol Psychiatry2006，797，： | 1 |
| 3 | Possible spin polarization in a one-dimensional electron gas 显示文摘 | THOMAS K J NICHOLLS J T SIMMONS M Y | 1996 | Physical Review Letters1996，77，1： | 1 |
| 4 | Separation of Eperythrozoon ovis from erythrocytes显示文摘 | Lang F M Ferrier G R Nicholls T J | 1986 | Vet Rec1986，119，： | 1 |
| 5 | Resilience to natural hazards: how useful is this concept 显示文摘 | Klein R J T Nicholls R J Thomalla F | 2003 | Global Environmental Change Part B: Environmental Hazards2003，5，12： | 1 |
| 6 | Pharmacodynamics and pharmacokinetics of AMG-531, a novel thrombopoietin receptor ligand 显示文摘 | Wang B Nichol J L Sullivan J T | 2004 | Clin Pharm Ther2004，76，6： | 1 |
| 7 | Swine models of type 2 diabetes mellitus : insulin resistance, glucose tolerance, and cardiovascular complications 显示文摘 | Bellinger D A Merricks E P Nichols T C | 2006 | ILAR J2006，47，3： | 1 |
| 8 | Rapid detection of vesicular stomatitis virus New Jersey serotype in clinical samples by using polymerase chain reaction显示文摘 | Rodriguez L L Lecthworth G J Nichol S T | 1993 | J Clin Microbiol1993，31，： | 1 |
| 9 | Structural health monitoring through chaotic interrogation 显示文摘 | Nichols J M Trickey S T Todd M D | 2003 | Mec- canica2003，，38： | 1 |
| 10 | 查看详情显示文摘 | J M Nichols S T Trickey M D Todd | | 0，，： | 1 |
| 11 | Congestive heart failure in type 2 diabetes: prevalence, incidence, and risk factors 显示文摘 | Nichols G A Hillier T A Erbey J R | 2001 | Diabetes Care2001，24，9： | 1 |
| 12 | Discrimination and Reliability in Q- Sort Personality Descriptions 显示文摘 | Livson N Nichols T | 1956 | J Abnorm Psychol1956，52，： | 1 |
| 13 | Damage detection using multivariate recurrence quantification analysis显示文摘 | Nichols J M Trickey S T Seaver M | 2006 | Mechanical Systems and Signal Processing2006，20，2： | 1 |
| 14 | Relationship of paraoxonase-1(PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk显示文摘 | Bhattacharyya T Nicholls SJ Topol EJ | 2008 | JAMA2008，299，11： | 1 |
| 15 | Morphometry of human insular cortex and insular volume reduction in Williams syndrome显示文摘 | Cohen J D Mock J R Nichols T | 2010 | J Psychiatr Res2010，44，2： | 1 |
| 16 | Predictors of asthma control and lung function responsiveness tostep 3 therapy in children with uncontrolled asthma显示文摘 | Nathan Rabinovitch David T Mauger Nichole Reisdorph | 2014 | The Jour-nal of Allergy and Clinical Immunology2014，13，32： | 1 |
| 17 | Charge compensation and site-selective luminescence of Cr3+:LiNbO3显示文摘 | HAN T P J HENDERSON B | 1993 | Chem Phys Lett1993，202，： | 1 |
| 18 | Low gradient permeability measurements in a triaxial system 显示文摘 | Nichols R W Rice T L | 1985 | Geotechnique1985，35，2： | 1 |
| 19 | BNP: not just for heart failure 显示文摘 | Nicholls M G Frampton C M Yandle T G | 2008 | Heart2008，94，1： | 1 |
| 20 | Continuous improvements in 'chain of survival' increased survival Mter out - of - hospital cardiac arrests, a largescale population- based study显示文摘 | Iwami T Nichol G Hiraide A | 2009 | Circulation2009，119，： | 1 |
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