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| 1 | CaMKII in cerebral ischemia显示文摘神经原上的 Ischemic 侮辱触发引起 Ca 导致 neuronal 房间死亡(excitotoxicity ) 的 2+ 超载的过多的、病理学的 glutamate 版本。Ca 2+/calmodulin (凸轮) 依赖者蛋白质 kinase II (CaMKII ) 是位于 neuronal 粘性下面并且学习的生理的有刺激性的 glutamate 信号的一个主要调停人。Glutamate 刺激在 T286 触发 CaMKII 的 autophosphorylation,使 kinase 成为 “ 的一个过程; autonomous”(从 Ca 2+ 刺激的部分活跃的独立人士) 并且那为 synaptic 的形式被要求粘性。最近的研究为侮辱以后的 neuroprotection 作为潜在的药目标也建议了自治 CaMKII 活动,在在 neuronal 文化的 glutamate 侮辱以后并且在在 vivo 的焦点的服的局部缺血以后。然而, CaMKII 和凸轮 kinase 家庭的另外的成员在 neuronal 死亡和幸存的规定被含有。这里,我们在 excitotoxicity 和服的局部缺血讨论过去的调查结果和凸轮 kinase 功能的可能的机制,与 CaMKII 和它的规定的一个焦点。 | Steven J COULTRAP Rebekah S VEST Nicole M ASHPOLE Andy HUDMON K Ulrich BAYEF | 2011 | Acta Pharmacologica Sinica2011，32，7： | 6 |
| 2 | 在有症状的患者中,与传统危险因素相比,冠状动脉钙化积分能更准确地预测显著的冠状动脉狭窄:欧洲钙化性冠状动脉疾病研究显示文摘在这项回顾性研究中,研究人员评估了冠状动脉钙化积分相对于传统危险因素对显著狭窄(冠状动脉狭窄〉50%)的预测价值。方法与结果:纳入来自丹麦、法国、德国、意大利、西班牙和美国有症状的患者5515例,所有研究对象均进行危险因素评估、计算机断层冠状动脉造影(computed tomographic coronary angiogram,CTCA)或常规血管造影。 | 刘莉 叶鹏 Nicoll R Wiklund U Zhao Y Diederichsen A Mickley H Ovrehus K Zamorano P Gueret P Schmermund A Maffei E Cademartiri F Budoff M Henein M | 2016 | 中华高血压杂志2016，24，3： | 4 |
| 3 | Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage显示文摘Anabolic steroid abuse is common among athletes and is associated with a number of medical complications. We describe a case of a 27-year-old male bodybuilder with multiple hepatic adenomas induced by anabolic steroids. He initially presented with tumor hemorrhage and was treated with left lateral hepatic segmentectomy. Regression of the remaining tumors was observed with cessation of steroid use. However, 3 years and a half after his initial hepatic segmentectomy, he presented with recurrent tumor enlargement and intraperitoneal hemorrhage in the setting of steroid abuse relapse. Given his limited hepatic reserve, he was conservatively managed with embolization of the right accessory hepatic artery. This is the first reported case of hepatic adenoma re- growth with recidivistic steroid abuse, complicated by life-threatening hemorrhage. While athletes and bodybuilders are often aware of the legal and social ramifications of steroid abuse, they should continue to be counseled about its serious medical risks. | Nicole M Martin Barham K Abu Dayyeh Raymond T Chung | 2008 | World Journal of Gastroenterology2008，14，28： | 3 |
| 4 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 5 | Fluid Stochastic Petri Nets: Theory, Applications and Solution 显示文摘 | G Horton V G Kulkami D M Nicol K S Trivedi | 1998 | European Journal of Operations Research (S0377-2217)1998，105，1： | 1 |
| 6 | Dandy-Walker malfor- mation:prenatal diagnosis and outcome显示文摘 | Nicole K Josef W Josef K | 2000 | Prenat Diagn2000，20，4： | 1 |
| 7 | Oxidant stress,immune dysregu- lation,and vascular function in type I diabetes显示文摘 | Nicolls MR Haskins K Flores SC | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 8 | Oxidant stress, im mune dysregulation, and vascular function in type I diabetes显示文摘 | NICOLLS M R HASKINS K FLORES S C | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 9 | Chronic ethanol consumption restores the age-related decrease in neurogranin mRNA level in the hippocampus of mice 显示文摘 | Ali K Nicole M Paul H | 2003 | Neurosci Lett2003，338，： | 1 |
| 10 | Integration of desalinated seawater into a distribution system:A corrosion pilot study显示文摘 | Nicole K Blute Michael J Mcguire Nicole West | 2008 | Journal of Ameri- can Water Works Association2008，100，： | 1 |
| 11 | OXidant stress,immune dysregulation, and vascular function in type I diabetes 显示文摘 | Nicolls MR Haskins K Flores SC | 2012 | AntioXid Redo X Signal2012，9，7： | 1 |
| 12 | OXidant stress,immune dysregulation,and vascular function in type I diabetes显示文摘 | Nicolls MR Haskins K Flores SC | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 13 | Bronchial collapse during bronchoalveolar lavage in horses is an indicator of lung inflammation显示文摘 | Koblinger K Hecker K Nicol J | 2014 | Equine Vet J2014，46，1： | 1 |
| 14 | Non-destructive measurement of acidity, soluble solids, and firmness of Jonagold apples using MR-spectroscopy 显示文摘 | Lammertyn J Nicolal B Ooms K | 1998 | Transactions of the ASAE1998，41，4： | 1 |
| 15 | Oxidant stress,immune dysregulation,and vascular function in type 1 diabetes显示文摘 | Nicolls MR Haskins K Flores SC | 2012 | Antioxid Redox Signal2012，9，7： | 1 |
| 16 | Dense medium separation u- sing a teetered bed separator显示文摘 | Galvin K P Pratten S J Nicol S K | 1999 | Minerals Engineering1999，12，9： | 1 |
| 17 | Oxidant stress, immune dysregulation, and vascular function in type 1 diabetes显示文摘 | Nicolls MR Haskins K Flores SC | 2007 | Antioxid Redox Signal2007，9，7： | 1 |
| 18 | OXidant stress, im- munedy sregulation, and vascular function in type I diabetes显示文摘 | NICOLLS MR HASKING K FLORES S C | 2012 | Antio xid redo x signal2012，9，7： | 1 |
| 19 | Impaired neuronal plasticity in transgenie mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion 显示文摘 | White F Nicoll JA Horsburgh K | 2001 | Neurobiol Dis2001，8，4： | 1 |
| 20 | Densemedium separation using a teetered bed separator显示文摘 | GALVIN K P PRATTEN S J NICOL S K | 1999 | Minerals Engineering1999，12，9： | 1 |
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