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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | 巨噬细胞中缺氧诱导因子1α表达促进动脉粥样硬化的发展显示文摘粥样硬化病变包含缺氧区域,但缺氧病理生理的重要性未知。缺氧诱导因子1a(hypoxia-induciblefactor-1α,HIF-1α)是细胞对低氧反应的关键转录因子。研究人员对HIF-1α在巨噬细胞促进小鼠动脉粥样硬化的生物学效应方面进行调查和验证。 | 刘莉 叶鹏 Aarup A Pedersen TX Junker N Christoffersen C Bartels ED Madsen M Nielsen CH Nielsen LB | 2016 | 中华高血压杂志2016，24，9： | 3 |
| 3 | Esophageal lichen planus:A case report and review of the literature显示文摘Esophageal involvement by lichen planus(ELP),previously thought to be quite rare,is a disease much more common in women and frequently the initial manifestation of mucocutaneous lichen planus(LP).Considering that the symptoms of ELP do not present in a predictable manner,ELP is perhaps more under-recognized than rare.To date,four cases of squamous cell carcinoma in association with ELP have been reported,suggesting that timely and accurate diagnosis of ELP is of importance for appropriate follow-up.In this case report,a 69-year-old female presented with dysphagia and odynophagia.She reported a history of oral LP but had no active oral or skin lesions.Endoscopic examination revealed severe strictures and web-like areas in the esophagus.Histologic examination demonstratedextensive denudation of the squamous epithelium,scattered intraepithelial lymphocytes,rare eosinophils and dyskeratotic cells.Direct immunofluorescence showed rare cytoid bodies and was used to exclude other primary immunobullous disorders.By using clinical,endoscopic,and histologic data,a broad list of differential diagnoses can be narrowed,and the accurate diagnosis of ELP can be made,which is essential for proper treatment and subsequent follow-up. | Jennifer A Nielsen Robert M Law Keith H Fiman Cory A Roberts | 2013 | World Journal of Gastroenterology2013，19，14： | 1 |
| 4 | Upwelling-driven nearshore hypoxia signals ecosystem and oceanographic changes in the northeast Pacific显示文摘 | GRANTHAM B A CHAN F NIELSEN K J | 2004 | Nature2004，429，6993： | 1 |
| 5 | MRS applicability for a study of glacial sedimentary aquifers in Central Jutland,Denmark显示文摘 | Chalikakis K Nielsen M R Legchenko A | 2008 | Journal of Applied Geophysics2008，66，34： | 1 |
| 6 | Modified water regime and salinity as a consequence of climate change: Prospects for wetl rods of Southern Australia 显示文摘 | NIELSEN D L BROCK M A | 2009 | Climatic Change2009，95，34： | 1 |
| 7 | Reinforced Concrete Response to Simulated Earthquakes 显示文摘 | TAKEDA T SOZEN M A NIELSEN N N | 1970 | Journal of the Structural Engineering ASCE1970，96，12： | 1 |
| 8 | Reinforced concrete response to simulated earthquake显示文摘 | TAKEDA T SOZEN M A NIELSEN N N | 1970 | Proc ASCE1970，，12： | 1 |
| 9 | Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity 显示文摘 | Jakobsen A Nielsen JN Gyldenkerne N | 2005 | J Clin Oncol2005，23，7： | 1 |
| 10 | Posterior capsule opacification and Nd: YAG Capsulotomy with heparin -surface -modified intraoc- ular lenses显示文摘 | Winther - Nielsen A Johansen J Pedersen G K | 1998 | J Cataract Surg1998，24，： | 1 |
| 11 | Kinetics, diffusional limitation and microscale distribution of chemistry and organisms in a CANON reactor显示文摘 | Nielsen M Bollmann A Sliekers O | 2005 | FEMS Microbiol Ecol2005，51，2： | 1 |
| 12 | Actuator control of edgewise vibrations in wind turbine blades显示文摘 | Staino A Basu B Nielsen S R K | 2012 | Journal of Sound and Vibration2012，331，： | 1 |
| 13 | A lignan from needles of himalayan Taxus baccata 显示文摘 | Fonseca S F Nielsen T L Rhveda E A | 1978 | Phytochemistry1978，17，： | 1 |
| 14 | Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state 显示文摘 | Nielsen FS Petersen KB Mfillertz A | 2008 | Eur J Pharm Biopharm2008，69，2： | 1 |
| 15 | Cellular and molecular biology of the aquaporin water channels显示文摘 | Borgnia M Nielsen S Engel A | 1999 | Biochem1999，68，： | 1 |
| 16 | Kidney dimensions at sonography: correlation with age, sex, and habitus in 665 adult volunteers 显示文摘 | EMAMIAN S A NIELSEN M B PEDERSEN J F | 1993 | AJR Am J Roentgen- ol1993，160，1： | 1 |
| 17 | Cellular and molecular biology of the aquaporin water channels显示文摘 | Borgnia M Nielsen S Engel A | 1999 | Annual Review of Biochemistry1999，68，： | 1 |
| 18 | Characterization of activated sludge floes by confooal laser scanning microscopy and image analysis显示文摘 | Schmid M Thill A Purkhold U Walcher M Bottero J Y Ginestet P Nielsen P H Wuertz S Wagner M | | 0，，09： | 1 |
| 19 | MAMP (microbe-associated molecular pattern) triggered immunity in plants 显示文摘 | NEWMAN M A SUNDELIN T NIELSEN J T | 2013 | Plant-Microbe Interaction2013，4，： | 1 |
| 20 | Effects of papain and a microbial enzyme on meat proteins and beef tenderness显示文摘 | ASHIE I N A SORENSEN T L NIELSEN P M | 2002 | Food Science2002，67，： | 1 |
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