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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Recent patterns and mechanisms of carbon exchange by terrestrial ecosystems显示文摘 | Schimel D S House J I Hibbard K A Bousquet P Ciais P Peylin P Braswell B H Apps M J Baker D Bondeau A Canadell J Churkina C: Cramer W Denning A S Field CB Friedlingstein P Goodale C Heimann M Houghton RA Melillo J M Moore B 3rd Murdiyarso D Noble L Pacala S W Prentice I C Raupach M R Rayner P J Scholes R J Steffen W L Wirth C | 2001 | Nature2001，414，： | 1 |
| 3 | Antioxidant systems of the avian embryo:Tissuespecific accumulation and distribution vitamin E in the Turkey embryo during development显示文摘 | Surai P F Sparks N H Noble R C | 1999 | British Poultry Science1999，40，4： | 1 |
| 4 | Application of neural computing methods for interpreting phospholipid fatty acid profiles of natural microbial communities显示文摘 | Noble P A Almeida J S Lovell C R | 2000 | Applied and Environmental Microbiology2000，66，2： | 1 |
| 5 | Anatomy, pathologic features, and treatment of acetabular labral tears显示文摘 | McCarthy J C Noble P C Aluisio F V | 2003 | Clin Orthop Re- lat Res2003，，406： | 1 |
| 6 | Australian landuse,primary production of vegetation and carbon pools in relation to atmospheric CO2 levels显示文摘 | Gifford R M Cheney N P Noble J C | 1992 | Bureau of Rural Proceedings1992，14，： | 1 |
| 7 | Optimal location of a single distal interlocking screw in intramedullary nailing of distal third femoral shaft fractures显示文摘 | George C J Lindsey R W Noble P C | | 0，，： | 1 |
| 8 | Tissue-specific differences in antioxidant distribution and susceptibility to lipid peroxidation during development of the chick embryo 显示文摘 | Surai P F Noble R C Speaker B K | 1996 | Biochim Biophys Acta1996，1304，1： | 1 |
| 9 | 显示文摘 | Floriano P N Noble C O Schoonmaker J M | 2001 | J Am Chem Soc2001，123，10： | 1 |
| 10 | The anatomic basis on femoral component design显示文摘 | NOBLE P c ALEXANDER J W LINDAHL L J | 1988 | Clin Orthop1988，235，： | 1 |
| 11 | Screw versus plate fixation of proximal first metatarsal crescentic osteotomy显示文摘 | Vamer K E Matt V Alexander J W Johnston J D Younas S Marymont J V Noble P C | 2009 | Foot An- kle lnt2009，30，2： | 1 |
| 12 | Descriptive analysis and ouality rating of 1976 wines from four Bordeaux communes显示文摘 | NOBLE A C WILLIAMS A A LANGON S P | 1984 | J Sci Food Agric1984，35，1： | 1 |
| 13 | Species-specific differences in the fatty acid profiles of the fipids of the yolk and of the liver of the chick显示文摘 | Surai P F Speake B K Noble R C | 1999 | Sci FS Agri1999，79，： | 1 |
| 14 | Changing tourism demand in central Europe:The case of Romanian tourist spas显示文摘 | Cooper C P Fletcher J Noble A | 1995 | Journal of Tourism Studies1995，6，2： | 1 |
| 15 | Size and chemical characterization of individual particles resulting from biomass burning of local Southern California Species 显示文摘 | Silva P J Liu D Y Noble C A | 1999 | Environmental Science & Technology1999，33，18： | 1 |
| 16 | Development of neutral polymeric bonding agents for propellants with polar composites filled with organic nitramine crystals显示文摘 | KIM C S YOUN H NOBLE P N | 1992 | Propellants Explosives Pyrotechnics1992，17，1： | 1 |
| 17 | The John lnsall Award: patient expectations affect satisfaction with total knee arthroplasty 显示文摘 | Noble P C Conditt M A Cook K F | 2006 | Cliu Orthop Relat Res2006，452，： | 1 |
| 18 | The relationship between the alpha-tocopherol content of the yolk and its accumulation in the tissues of the newly hatched chick显示文摘 | Surai P F Gaal T Noble R C | 1997 | Journal of the Science of Food and Agriculture1997，75，2： | 1 |
| 19 | Pressurization centalization enhance the quality reproducibility and cement mantles显示文摘 | Noble P C Colier M B Maltry G A | 1998 | Clin Orthop1998，225，355： | 1 |
| 20 | The effect of aging on the shape of the proximal femur 显示文摘 | Noble P C Box G G Kamaric E | 1995 | Clin Orthop1995，316，2： | 1 |
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