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| 1 | 艾地苯醌治疗缺血性脑血管疾病的药理作用及临床应用显示文摘动物实验证实艾地苯醌具有对发生脑卒中的大鼠脑线粒体功能有激活作用、对脑能量代谢及脑功能障碍有改善作用,艾地苯醌的T_(1/2)为7.69h,T_(max)3.31h,C_(max)为290ng/mL,24h尿中排泄率为32%。艾地苯醌治疗脑动脉硬化症和脑梗死后遗症30例(男24例,女6例;年龄67±23a)总改善率90%,情感障碍、智力低下、行动异常等改善率73%-81%,不良反应轻微。 | 杨学义 韩宝福 崔世贞 Akinobu Nagaoka | 1993 | 新药与临床1993，12，1： | 11 |
| 2 | Fenofibrate-induced liver injury显示文摘TO THE EDITOR
Fenofibrate is a member of such fibrate class agents as bezafibrate and it work as a ligand of PPARα, and also shows a potent triglyceride-lowering effect. The elevation of aminotransferase levels has been frequently observed after the administration of fenofibrate and this phenomenon is considered to be non-pathological because fenofibrate activates the gene expression of the aminotransferases. Recently, fenofibrate has been used not only for hypercholesterolemia but also for primary biliary cirrhosis (PBC)[1,2]. However, the occurrence of liver injury induced by fenofibrate has not yet been reported written in the English literature. We herein report a rare case of liver injury due to the oral use of this drug. | Kazufumi Dohmen Chun Yang Wen Shinya Nagaoka Koji Yano Seigo Abiru Toshihito Ueki Atsumasa Komori Manabu Daikoku Hiroshi Yatsuhashi Hiromi Ishibashi | 2005 | World Journal of Gastroenterology2005，11，48： | 7 |
| 3 | AngiotensinⅡor epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats显示文摘AIM To study hepatic vasoconstriction and glucose release induced by angiotensin(Ang)Ⅱ or Epi in rats with pharmacological hypertension and spontaneously hypertensive rat(SHR).METHODS Isolated liver perfusion was performed following portal vein and vena cava cannulation; AngⅡ or epinephrine(Epi) was injected in bolus and portal pressure monitored; glucose release was measured in perfusate aliquots. RESULTS The portal hypertensive response(PHR) and the glucose release induced by AngⅡ of L-NAME were similar to normal rats(WIS). On the other hand, the PHR inducedby Epi in L-NAME was higher whereas the glucose release was lower compared to WIS. Despite the similar glycogen content, glucose release induced by AngⅡ was lower in SHR compared to Wistar-Kyoto rats although both PHR and glucose release induced by Epi in were similar. CONCLUSION AngⅡ and Epi responses are altered in different ways in these hypertension models. Our results suggest that inhibition of NO production seems to be involved in the hepatic effects induced by Epi but not by AngⅡ; the diminished glucose release induced by AngⅡ in SHR is not related to glycogen content. | Debora Conte Kimura Marcia Regina Nagaoka Durval Rosa Borges Maria Kouyoumdjian | 2017 | World Journal of Hepatology2017，9，17： | 4 |
| 4 | ICRF Heated Long-Pulse Plasma Discharges in LHD显示文摘A long-pulse plasma discharge for more than 30 min.was achieved on the LargeHelical Device(LHD).A plasma of n_e=0.8×10^(19)m^(-3)and T_(iO)=2.0 keV was sustained withP_(ICH)=0.52 MW,P_(ECH)=0.1 MW and averaged P_(NBI)=0.067 MW.Total injected heatingenergy was 1.3 GJ,which was a quarter of the prepared RF heating energy.One of the keys to thesuccess of the experiment was a dispersion of the local plasma heat load to divertors,accomplishedby shifting the magnetic axis inward and outward. | R. KUMAZAWA T. SEKI T. MUTOH K. SAITO T. WATARI Y. NAKAMURA M. SAKAMOTO T. WATANABE S. KUBO T. SHIMOZUMA Y. YOSHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. NAGAOKA O. KANEKO J. MIYAZAWA S. MORITA K. NARIHARA M. SHOJI S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSON K. SATO T. TOKUZAWA N. ASHIKAWA K. NISHIMURA H. FUNABA H. CHIKARAISHI T. NOTAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKASE H. KASAHARA F. SHIMPO G.NOMURA C.TAKAHASHI M.YOKOTA A. KATO 赵燕平 J. S. YOON J. G. KWAK H. YAMADA K. KAWAHATA N. OHYABU K. IDA Y. NAGAYAMA N. NODA A. KOMORI S. SUDO O. MOTOJIMA | 2006 | Plasma Science and Technology2006，8，1： | 4 |
| 5 | Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection—association between TGF-β1 polymorphisms and hepatocellular carcinoma显示文摘 | Kiyoshi Migita Seiji Miyazoe Yumi Maeda Manabu Daikoku Seigo Abiru Tshihito Ueki Koji Yano Shinya Nagaoka Takehiro Matsumoto Kazuhiko Nakao Keisuke Hamasaki Hiroshi Yatsuhashi Hiromi Ishibashi Katsumi Eguchi | 2004 | Journal of Hepatology2004，，4： | 3 |
| 6 | Genetic linkage map of ISSR and RAPD markers in Einkorn wheat in relation to that of RFLP markers显示文摘 | KOJIMA T NAGAOKA T NODA K | 1998 | Theor Appl Genet1998，96，1： | 2 |
| 7 | Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients显示文摘 | Takatoshi Kakuta Reika Tanaka Toru Hyodo Hajime Suzuki Genta Kanai Mikako Nagaoka Hiroo Takahashi Nobuhito Hirawa Yoichi Oogushi Toshio Miyata Hiroyuki Kobayashi Masafumi Fukagawa Akira Saito | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 8 | Influence of Bacterial Extracellular Polymers on the Membrane Separation Activated Sludge Process 显示文摘 | Nagaoka H Veda S Miya A | 1996 | Wat Sci Tech1996，34，9： | 1 |
| 9 | Identification of novel hypocholesterolemic peptides derived from bovine milk β -Lactoglobulin 显示文摘 | NAGAOKA S FUTAMURA Y MIWA K | 2001 | Biochemical and Biophysical Research Communication2001，281，： | 1 |
| 10 | Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes 显示文摘 | Nagaoka T Kitaya N Sugawara R | 2004 | Br J Ophthalmol2004，88，： | 1 |
| 11 | Identifica- tion of novel hypocholesterolemic peptides derived from bo- vine mlikβ - laetoglobulin 显示文摘 | Satoshi Nagaoka Yu Futamura Keiji Miwa | 2001 | Biochemical and Biophysical Research Communications2001，281，： | 1 |
| 12 | Cyclic nucleotidephosphodiesterase 3 expression in vivo:evidence for tissuespecificexpression of phosphodiesterase 3A or 3B mRNA andactivity in the aorta and adipose tissue of atherosclerosis-proneinsulin-resistant rats显示文摘 | Nagaoka T Shirakawa T Balon TW | 1998 | Diabetes1998，47，： | 1 |
| 13 | 显示文摘 | Namba Naoko Yoshida Yasuhiro Nagaoka Noriyuki | 2009 | Dental Materials2009，25，4： | 1 |
| 14 | Active control of flutter of a suspension bridge 显示文摘 | Kobayashi H Nagaoka H | 1992 | Jounal of Wind Engeering and Industrial Areodynamics1992，41，1： | 1 |
| 15 | Influence of bacterial extracellular polymers on the membrane separation activated sludge process 显示文摘 | Nagaoka H Ueda S Miya A | 1996 | Water Science and Technology1996，34，9： | 1 |
| 16 | Pharmacokinet- ics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid es- ters显示文摘 | Hasegawa H Lee KS Nagaoka T | 2000 | Biol Pharm Bull2000，23，3： | 1 |
| 17 | Modeling of Biofouling by Extracellular Polymers in a Membrane Separation Activated Sludge System 显示文摘 | Nagaoka H Yamanishi S Miya A | 1998 | W at Sci Tech1998，38，45： | 1 |
| 18 | Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis:association with extent of skin sclerosis and severity of pulmonary fibrosis显示文摘 | Sato S Nagaoka T Hasegawa M Tamatani T Nakanishi T Takigawa M | 2000 | J Rheumatol2000，27，1： | 1 |
| 19 | Influence of bacterial extracellular polymers on the membrane separation activated sludge process 显示文摘 | Nagaoka H Ueda S Miya A | 1996 | WaterSciTechnol1996，34，9： | 1 |
| 20 | Efiect of antibacterial cathelicidin peptide CAP18/LL- 37 on spesis in neo- natal rats显示文摘 | FUKUMOTO K NAGAOKA I YAMATAKA A | 2005 | Pediatr Surg Int2005，21，1： | 1 |
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