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| 1 | Pathophysiology of constipation in the older adult显示文摘This review provides information on the definition of constipation, normal continence and defecation and a description of the pathophysiologic mechanisms of constipation. In addition, changes in the anatomy and physiology of the lower gastrointestinal tract associated with aging that may contribute to constipation are described. MEDLINE (1966-2007) and CINAHL (1980-2007) were searched. The following MeSH terms were used: constipation/etiology OR constipation/ physiology OR constipation/physiopathology) AND (age factors OR aged OR older OR 80 and over OR middle age). Constipation is not well defined in the literature. While self-reported constipation increases with age, findings from a limited number of clinical studies that utilized objective measures do not support this association. Dysmotility and pelvic floor dysfunction are important mechanisms associated with constipation. Changes in GI function associated with aging appear to be relatively subtle based on a limited amount of conflicting data. Additional research is warranted on the effects of aging on GI function, as well as on the timing of these changes. | G Lindsay McCrea Christine Miaskowski Nancy A Stotts Liz Macera Madhulika G Varma | 2008 | World Journal of Gastroenterology2008，14，17： | 21 |
| 2 | Gait speed and hospitalization among ambulatory hemodialysis patients: USRDS special study data显示文摘AIM:To assess the association of measured gait speed with hemodialysis(HD)patients’hospitalization,in conjunction with,and apart from,recent fall history.METHODS:Gait speed was measured by a standard protocol and falls during the past 12 mo were ascertained for a prevalent multi-center HD cohort(n=668)aged 20-92.Hospitalization during the past 12 mo was identified in the patient’s clinic records,and the first hospitalization after gait speed assessment(or the competing event of death)was identified in the 2013 United States Renal Data System Standard Analysis Files.RESULTS:Slow gait speed,defined as<0.8 m/s,characterized 34.7%of the patients,and 27.1%had experienced a recent fall.Patients with slow gait speed but without a history of recent falls were 1.79 times more likely to have been hospitalized during the past12 mo(OR=1.79,95%CI:1.11-2.88,P=0.02),and patients with slow gait speed and a history of recent falls were over two times more likely to have been hospitalized(OR=2.10,95%CI:1.19-3.73,P=0.01),compared with patients having faster gait speed and no recent fall history.Prospective examination of gait speed/fall history status in relation to first hospitalization(or death)incurred by the end of follow-up December 31,2011 also showed that slow gait speed was associated with these events in conjunction with a history of falls(HR=1.54,95%CI:1.04-2.30,P=0.03).CONCLUSION:The International Task Force on Nutrition and Aging reported that gait speed is a powerful predictor for older adults of adverse outcomes such as hospitalization.In our data,gait speed--apart from,as well as in conjunction with,recent fall history--was associated with HD patients’hospitalization for multiple causes.Gait speed may be a sensitive health indicator among HD patients across the age spectrum. | Nancy G Kutner Rebecca Zhang Yijian Huang Haimanot Wasse | 2014 | World Journal of Nephrology2014，3，3： | 8 |
| 3 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 4 | Safety as a system property显示文摘 | Nancy G Leveson | | 0，，11： | 1 |
| 5 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 6 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 7 | 16S rRNA based T-RFLP analysis of methane oxidizing bacteria Assessment, critical evaluation of methodology performance and application for landfill site cover soils显示文摘 | NANCY S LEVENTE B THOMAS G R | 2006 | Applied Soil Ecology2006，31，： | 1 |
| 8 | Evaluating surrogates for disinfection by-products显示文摘 | Issam N Najm Nancy L Patania Joseph G Jacangelo | 1994 | American Water Works Association Journal1994，86，6： | 1 |
| 9 | Preventing heel break- down显示文摘 | Marilyn K G Janet B Nancy B | 2000 | Orthop Nurs2000，19，5： | 1 |
| 10 | Uncertainty in estimating carbon emissions from boreal forest fires显示文摘 | Nancy H F F Pierre G Eric S K | 2004 | Journal of Geophysical Research2004，109，： | 1 |
| 11 | M Mastalen Chemical Fractionation of Metals in Wetland Sediments: Indiana Dunes National Lakeshore 显示文摘 | Dollar Nancy L C J Souch G M Filippelli | 2001 | Environmental Science & Technology2001，35，18： | 1 |
| 12 | Suppression of rice methane emission by sulfate deposition in simulated acid rain 显示文摘 | Gauci V Nancy B Howell G | 2008 | Journal of Geophysical Research2008，113，07： | 1 |
| 13 | Cancer and Comorbidity显示文摘 | Karen S O G Marie Swanson Nancy Woods | 2000 | Cancer2000，，88： | 1 |
| 14 | The Relation between Systematic Reviews and Practice Guidelines显示文摘 | Nancy L G Gray Ellrodt | 1997 | Annal of Internal Medicine1997，127，3： | 1 |
| 15 | Call to action on use and reimbursement for home blood pressure monitoring: executive summary: a joint scientific statement from the American heart asso- ciation, American society of hypertension , and preventive cardio- vascular nurses association显示文摘 | Thomas G P Nancy H M Gbenga O | 2008 | J Am Soc Hypertension2008，2，3： | 1 |
| 16 | Predicting Corporate Performance from organizational culture显示文摘 | George G Gordon Nancy DiTmaso | 1992 | Journal of Management Studies1992，，： | 1 |
| 17 | Evidence of the effects of water quality on residential land prices 显示文摘 | Christopher G L Nancy E B | 2000 | Journal of Environmental Economies and Manage- ment2000，39，2： | 1 |
| 18 | The career reasons of nascent entrepreneurs显示文摘 | Nancy M Carter William B Gartner Kelly G Shaver Elizabeth J Gatewood | 2002 | Journal of Business Venturing2002，，1： | 1 |
| 19 | Selection and characterization of mixed starter cultures for lactic acid fermentation of carrot, cabbage, beet and onion vegetable mixtures 显示文摘 | NANCY J G TONY S PAULE O | 2001 | Int J Food Microbiol2001，64，： | 1 |
| 20 | Selection and characterization of mixed starter cultures for lactic acid fermentation of carrot , cabbage , beet and onion vegetable mixture 显示文摘 | Nancy J G | 2001 | Int J Food Microbiol2001，64，： | 1 |
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