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146篇 您的检索式:作者名="Naora"
    题名 作者 年代 出处 被引量
1Therapeutic strategies for targeting the ovarian tumor stroma显示文摘Epithelial ovarian cancer is the most lethal type of gynecologic malignancy. Sixty percent of women who are diagnosed with ovarian cancer present with advancedstage disease that involves the peritoneal cavity and these patients have a 5-year survival rate of less than 30%. For more than two decades, tumor-debulking surgery followed by platinum-taxane combination chemotherapy has remained the conventional first-line treatment of ovarian cancer. Although the initial response rate is 70%-80%, most patients with advancedstage ovarian cancer eventually relapse and succumb to recurrent chemoresistant disease. A number of molecular aberrations that drive tumor progression have been identified in ovarian cancer cells and intensive efforts have focused on developing therapeutic agents that target these aberrations. However, increasing evidence indicates that reciprocal interactions between tumor cells and various types of stromal cells also play important roles in driving ovarian tumor progression and that these stromal cells represent attractive therapeutic targets. Unlike tumor cells, stromal cells within the tumor microenvironment are in general geneticallystable and are therefore less likely to become resistant to therapy. This concise review discusses the biological significance of the cross-talk between ovarian cancer cells and three major types of stromal cells(endothelial cells, fibroblasts, macrophages) and the development of new-generation therapies that target the ovarian tumor microenvironment.Song Yi Ko Honami Naora 2014World Journal of Clinical Cases2014,2,6:4
2Downregulation of KiSS - 1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma 显示文摘Dhar DK Naora H Kubota H 2004Int J Cancer2004,111,6:1
3Downregulation of KiSS-1 expression is responble for tumor invasion and worse prognosis in gastri carcinoma显示文摘Dhar DK Naora H Kubota H 2004Int J Cancer2004,111,3:1
4Activated signal transducer and activator of transcription (STAT) 3:Localization in focal adhesions and function in ovarian cancer cell molitity显示文摘Silver DL Naora H Liu J 2004Cancer Res2004,64,:1
5Aberrant expression of homeobox gene HOXA7 is associated with mullerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response显示文摘Naora H Montz FJ Chai CY 2001Proc Natl Acad Sci U S A2001,98,15:1
6Ovarian cancer metastasis: integrating insights from disparate model organisms 显示文摘NAORA H MONTELL DJ 2005Nat Rev Cancer2005,5,5:1
7Excretion of ofloxacin into saliva in rats with renal failure显示文摘Ding GH Naora KJ Nagasako SA 1998J Pharmaco Exp Ther1998,287,1:1
8A serologically identified tumor antigen encoded by a homeobox gene growth of ovarian epithetial cells显示文摘Naora H Yang YQ Montz FJ 2001Proc Natl Acad Sci U S A2001,98,7:1
9Relationship between the total size of exonsand introns in protein-coding genes of higher eukaryotes显示文摘Naora H Deacon NJ 1982ProcNatl Acad Sci USA1982,79,20:1
10Ovarian cancer metastasis: integrating insights from disparate model organisms 显示文摘Naora H Montell DJ 2005Nat Rev Cancer2005,5,:1
11Activated signal transducer and activator of transcription STAT 3 : localization in focal adhesions and function in ovarian cancer cell motility 显示文摘Silver DL Naora H Liu J 2004Cancer Res2004,64,10:1
12Down-regulated RPS3a/nbl expression during retinoid-induced differentiation of HL-60 cells: a close association with diminished susceptibility to actinomycin D- stimulated apoptosis显示文摘Russell L Naora H Naora H 2000Cell Struct Funct2000,,25:1
13The Mullerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial- stromal interactions 显示文摘KO S Y LENGYEL E NAORA H 2010Mol Cell Endocrinol2010,317,:1
14Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma显示文摘DHAR DK NAORA H KUBOTA H 2004Iht J Cancer2004,111,6:1
15Simultaneous high-performance liquid chromatographic determination of ciprofloxacin,fenbufen and felbinac in rat plasma显示文摘Naora K kataqiri Y Ichikawa N 1990chrom1990,530,:1
16Pharmaeokinetics of - gingerol after intravenous administration in rats显示文摘Ding GH Naora K Hayashibara M 1991Chem Phann Bull1991,39,6:1
17Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma显示文摘DHAR DK NAORA H KUBOTA H 2004Int J Cancer2004,111,6:1
18Expression of the longform of leptin receptor(Ob-Rb)mRNA in the brain of mouseembryos and newborn mice显示文摘Udagawa J Hatta T Naora H 2000Brain Res2000,868,2:1
19A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells显示文摘Naora H Yang YQ Montz FJ 2001Proc Natl Acad Sci USA2001,98,14:1
20Activated signal transducer and activator of transcription(STAT)3:localization in focal adhesions and function in ovarian cancer cel motility显示文摘 Naora H Liu J 2004Cancer Res2004,64,:1
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