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| 1 | Corticosteroids for severe influenza pneumonia: A critical appraisal显示文摘Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit(ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in s evere influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials. | Wagner Luis Nedel David Garcia Nora Jorge Ibrain Figueira Salluh Thiago Lisboa Pedro Póvoa | 2016 | World Journal of Critical Care Medicine2016，5，1： | 3 |
| 2 | Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages显示文摘Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cellsthat have great potential as cell therapy for autoimmune and inflammatorydisorders, as well as for other clinical conditions, due to their immunoregulatoryand regenerative properties. MSCs modulate the inflammatory milieu by releasingsoluble factors and acting through cell-to-cell mechanisms. MSCs switch theclassical inflammatory status of monocytes and macrophages towards a nonclassicaland anti-inflammatory phenotype. This is characterized by an increasedsecretion of anti-inflammatory cytokines, a decreased release of pro-inflammatorycytokines, and changes in the expression of cell membrane molecules and inmetabolic pathways. The MSC modulation of monocyte and macrophage phenotypesseems to be critical for therapy effectiveness in several disease models, sincewhen these cells are depleted, no immunoregulatory effects are observed. Here,we review the effects of living MSCs (metabolically active cells) and metabolicallyinactive MSCs (dead cells that lost metabolic activity by induced inactivation) andtheir derivatives (extracellular vesicles, soluble factors, extracts, and microparticles)on the profile of macrophages and monocytes and the implications forimmunoregulatory and reparative processes. This review includes mechanisms ofaction exhibited in these different therapeutic appro-aches, which induce the antiinflammatoryproperties of monocytes and macrophages. Finally, we overviewseveral possibilities of therapeutic applications of these cells and their derivatives,with results regarding monocytes and macrophages in animal model studies andsome clinical trials. | Alexia Nedel Sant'Ana Anelise Bergmann Araújo Fabiany da Costa Gonçalves Ana Helena Paz | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 3 | Tumor angiogenesis and lymphangiogenesis: Tumor/endothelial crosstalk and cellular/ mieroenvironmental signaling mechanisms显示文摘 | Gomes F G Nedel F Aires A M | 2013 | Life Sciences2013，92，2： | 1 |
| 4 | Mechanisms of oxidative stressand vascular Dysfunction显示文摘 | Nedel J Kovic ZS Gokce N | 2011 | Postgrad Med J2011，87，930： | 1 |
| 5 | Cognitive and emotional processing at high altitude显示文摘 | PAVILCEK V SCHINLO C NEDEL A | 2005 | Aviat Space Environ Med2005，76，1： | 1 |
| 6 | Characterization of Eyjafjallajokull volcanic ash particles and a protocol for rapid risk assessment显示文摘 | GISLASON S R HASSENKAM T NEDEL S | 2011 | Proceedings of the National Academy of Sciences2011，108，18： | 1 |
| 7 | Sepsis-induced mitochondrial dysfunction:A narrative review显示文摘Sepsis represents a deranged and exaggerated systemic inflammatory response to infection and is associated with vascular and metabolic abnormalities that trigger systemic organic dysfunction.Mitochondrial function has been shown to be severely impaired during the early phase of critical illness,with a reduction in biogenesis,increased generation of reactive oxygen species and a decrease in adenosine triphosphate synthesis of up to 50%.Mitochondrial dysfunction can be assessed using mitochondrial DNA concentration and respirometry assays,particularly in peripheral mononuclear cells.Isolation of monocytes and lymphocytes seems to be the most promising strategy for measuring mitochondrial activity in clinical settings because of the ease of collection,sample processing,and clinical relevance of the association between metabolic alterations and deficient immune responses in mononuclear cells.Studies have reported alterations in these variables in patients with sepsis compared with healthy controls and non-septic patients.However,few studies have explored the association between mitochondrial dysfunction in immune mononuclear cells and unfavorable clinical outcomes.An improvement in mitochondrial parameters in sepsis could theoretically serve as a biomarker of clinical recovery and response to oxygen and vasopressor therapies as well as reveal unexplored pathophysiological mechanistic targets.These features highlight the need for further studies on mitochondrial metabolism in immune cells as a feasible tool to evaluate patients in intensive care settings.The evaluation of mitochondrial metabolism is a promising tool for the evaluation and management of critically ill patients,especially those with sepsis.In this article,we explore the pathophysiological aspects,main methods of measurement,and the main studies in this field. | Wagner Nedel Caroline Deutschendorf Luis Valmor Cruz Portela | 2023 | World Journal of Critical Care Medicine2023，12，3： | 1 |
| 8 | Study of poly-1, 4-phenylene sulfide sulfone solutions 显示文摘 | GLAKOVA E A NEDEL'KIN V I OVSYANNIKOVA S I | 1992 | Vysokomolekularnye Soedineniya Seriya A1992，34，12： | 1 |
| 9 | Anatomically modeling of deformable human bodies显示文摘 | Nedel L P Thalmann D | 2000 | The Visual Computer2000，16，6： | 1 |
| 10 | A compare- tire study of risk tctors and outcome am ong outpatient-ac- quiredand nosoeomial candidaemi显示文摘 | Pasquaiotto AC Nedel WL Maehado TS | 2005 | J Hosp Infect2005，60，2： | 1 |
| 11 | Finite element micromechanical modelling of a unidirectional composite subjected to axial shearloading显示文摘 | Nedele M R Wisnom M R | 1994 | Composites1994，25，： | 1 |
| 12 | A compare-tire study of risk tctors and outcome am ong outpatient-ac-quiredand nosoeomial candidaemia显示文摘 | Pasquaiotto AC Nedel WL Maehado TS | 2005 | J Hosp Infect2005，60，2： | 1 |
| 13 | A 9-year study comparing risk factors and the outcome of paediatric and adults with nosocomial candidaemia 显示文摘 | Pasqualotto AC Nedel WL Machado TS | 2005 | Mycopathologia2005，160，2： | 1 |
| 14 | Delayed postischemic hypothermia improves long-term behavioral outcome after ceregral hypoxia-ischemia in neonatal rats显示文摘 | Wagner BP Nedelou J | 2002 | Pediatr Res2002，51，3： | 1 |
| 15 | A compare-tire study of risk tctors and outcome among outpatient-ac-quiredand nosoeomial candidaemia显示文摘 | Pasquaiotto AC Nedel WL Maehado TS | 2005 | J Hosp Infect2005，60，2： | 1 |
| 16 | CMCs research in Europe and the future potential of CMCs in industry 显示文摘 | Voorde M H Nedel M R | 1996 | Ceramic Engineering and Science Proceedings1996，，3： | 1 |
| 17 | CMCs: research in Europe and the future potential of CMCs in industry显示文摘 | VOORDE M H NEDEL M R | 1996 | Ceramic Engineering and Science Proceedings1996，17，4： | 1 |
| 18 | Three dimensional finite analysis of the stress concentration at a single fibre break显示文摘 | Nedele MR Wisnom MR | 1994 | Composites Science and Technology1994，51，： | 1 |
| 19 | A new score based on pro- calcitonin and chest echography for diagnosis of ventilator-associ- ated pneumonia : when How For whom 显示文摘 | Nedel WL Morais VD Richter PW | 2015 | Chest2015，147，3： | 1 |
| 20 | CD95-induced apoptosis contributes to loss of primed memory but not resting naive T cell in children infected with human immunodeficiency virus type显示文摘 | Nedel S Debatin KM | 1997 | Pediatr Res1997，41，6： | 1 |
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