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| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | 气象卫星云图的多分辨小波分解及人工神经网络降水估计研究显示文摘采用多分辨小波分析对卫星图象进行预处理 ,在保留其特征信息的同时 ,减小了数据量 ,改善了神经网络训练过程的收敛性能 ,提高了处理速度。采用这一方法根据 GOES- 8的红外亮温图象和气象雷达资料对巴西圣保罗州中部的降水量估计进行了试验 ,取得了良好的效果。 | 李伟钢 Maria C V Ramirez Nelson J Ferreira 石立华 Leonardo D de A Sá | 2000 | 南京气象学院学报2000，23，2： | 13 |
| 3 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | 用于电力系统仿真的潮流控制器模型显示文摘本文描述了—族基于可关断晶闸管(GTO)电压源逆变器的电力系统控制装置,介绍了静补(STATCON)、串联潮流控制器(SPFC)和统一潮流控制器(UPC)的稳态模型。静补是由美国的EPRI、TVA和西屋科技中心联合开发的基于逆变器的并联装置、不久它将被安装在TVA的16lkV输电系统上用于控制线路电压。而串联潮流控制器和统一潮流控制器则代表了静补在串联应用方面的拓展。这些装置的建模可以结合到现有的大型电力系统分析程序之中供系统稳态研究使用。IEEE的30母线试验系统的仿真结果证明了这些电压源潮流控制装置的稳态性能。UPFC具有能同时对线路的有功与无功潮流独立地进行控制的能力,可以认为它特别适用厂输电潮流控制。 | J. Bian Meniber T. A Lemak Member(Power benration Business Unit Science and Technology CenterWestinghouse Electric Corporation. Pittsburrgh, PA, USA)K J. Nelson Member D. G. Ramey Aenior Member(Power Genration Business UnitWestinghouse Electric Corporat | 1995 | 电网技术1995，19，9： | 3 |
| 6 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 7 | Space radiation and cardiovascular disease risk显示文摘Future long-distance space missions will be associated with significant exposures to ionizing radiation,and the health risks of these radiation exposures during manned missions need to be assessed. Recent Earth-based epidemiological studies in survivors of atomic bombs and after occupational and medical low dose radiation exposures have indicated that the cardiovascular system may be more sensitive to ionizing radiation than was previously thought. This has raised the concern of a cardiovascular disease risk from exposure to space radiation during long-distance space travel. Groundbased studies with animal and cell culture models play an important role in estimating health risks from space radiation exposure. Charged particle space radiation has dense ionization characteristics and may induce unique biological responses,appropriate simulation of the space radiation environment and careful consideration of the choice of the experimental model are critical. Recent studies have addressed cardiovascular effects of space radiation using such models and provided first results that aid in estimating cardiovascular disease risk,and several other studies are ongoing. Moreover,astronauts could potentially be administered pharmacological countermeasures against adverse effects of space radiation,and research is focused on the development of such compounds. Because the cardiovascular response to space radiation has not yet been clearly defined,the identification of potential pharmacological countermeasures against cardiovascular effects is still in its infancy. | Marjan Boerma Gregory A Nelson Vijayalakshmi Sridharan Xiao-Wen Mao Igor Koturbash Martin Hauer-Jensen | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 8 | Delay of disease development in transgenic plant that express the tobacco mosaic virus coat protein gene显示文摘 | Powell A P Nelson R S De B | 1986 | Science1986，232，： | 2 |
| 9 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 10 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 11 | 胱蛋白酶抑制剂相关的附睾精子发生基因的调节和功能显示文摘CRES(cystatin relatedepididymalspermatogenic,胱蛋白酶抑制剂相关的附睾精子发生 )蛋白是胱蛋白酶抑制剂(cystatin)超家族中家族 2的一个亚类。然而 ,与cystatinC的广泛性表达不同 ,Cres基因只在分裂后的生殖细胞、附睾头部近端和腺垂体促性腺激素细胞中表达。cystatin对C1半胱氨酸蛋白酶抑制作用的发挥必须有 3个共有位点的参与 ,而CRES蛋白缺少其中的 2个位点。因此 ,CERS在生殖系统和神经内分泌系统中的功能也许是独特的和组织特异性的。本文概述了以下方面的研究 :①Cres基因启动子及其转录调节蛋白相关的可能对Cres的组织特异性表达有重要作用的DNA结合位点。②CRES蛋白的生物学功能。Norethern印迹法、凝胶转移分析和瞬时转染实验均表明 ,附睾和促性腺激素细胞中主要表达C EBP家族中的C EBPβ(CCAAT 增强子结合蛋白 ) ,且C EBPβ对于Cres基因在这两个组织中的高表达是必不可少的。另外 ,构建了表达氯霉素乙酰基转移酶 (CAT)报告基因的转基因小鼠 ,CAT报告基因由Cres基因 5′端 1 6kb的启动子所调控。分析显示 ,CATmRNA仅在生殖细胞中表达 ,说明Cres 5′端 1 6kb的侧翼区含有调控CAT在睾丸中表达的DNA序列 ,而缺乏指导CAT在附睾中表达的序列 ,或者此1 6kb的DNA片段存在Cres的负调节成分。最后 , | Gail A CORNWALL Nelson HSIA | 2002 | 中华男科学杂志2002，8，5： | 2 |
| 12 | Janus kinases and their role in growth and disease显示文摘 | Aringer M Cheng A Nelson JW | 1999 | Life Sci1999，64，24： | 1 |
| 13 | The persistence and degradation of chlorothalonil and chlorpyrifos in a cranberry bog 显示文摘 | Putnam R A Nelson J O Clark J M | 2003 | Agric Food Chem2003，51，： | 1 |
| 14 | Entrepreneurship Research in Emergence:Past Trends and Future Directions显示文摘 | BUSENITZ L W WEST G F SHEPHERD D NELSON T CHANDLER G N ZACHARAKIS A | 2003 | Journal of Management2003，29，3： | 1 |
| 15 | The growth of patenting and licensing by US universities:an assessment of the effects of Bayh - Dole Act of 1980显示文摘 | Mowery D Nelson R Sampat B Zicdonis A | 2001 | Research Policy2001，，30： | 1 |
| 16 | Consistent Structure properties for AlN,GaN,and InN显示文摘 | Wright A F Nelson J S | 1995 | Phys Rev B1995，51，12： | 1 |
| 17 | Seasonal changes in the silicon cycle within a Gulf Stream warm core ring显示文摘 | BRZENZINSKI M A NELSON D M | 1989 | Deep-Sea Research1989，36，： | 1 |
| 18 | MR imaging of sports-related groin pain 显示文摘 | Nelson EN Kassarjian A Palmer WE | 2005 | Magn Reson hnaging Clin N Am2005，13，： | 1 |
| 19 | Mediation of seasonal testicular regression by apoptosis 显示文摘 | YOUNG K A NELSON R J | 2001 | Reproduction2001，122，5： | 1 |
| 20 | Ignition properties of thermally thin thermoplastic-the effectiveness of inert additives in reducing flammability显示文摘 | Nelson M I Brindley J McIntosh A C | 1996 | Polym Degrad Stab1996，54，23： | 1 |
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