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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 3 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 4 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 5 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 6 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 7 | Intelligent agents:theory and practice显示文摘 | Michael W Nicholas R J | 1995 | Knowledge Engineering1995，10，2： | 1 |
| 8 | A roadmap of agent research and development 显示文摘 | Katia S Michael W | 1998 | Autonomous Agents and Multi-Agent Systems1998，1，： | 1 |
| 9 | Effects of larval stocking den- sity on laboratory-scale and commersial-scale production ofsummer flounder Paralichthys dentatus显示文摘 | Nicholas J K Hunting W H | 2000 | J World Aqua- culture Society2000，31，3： | 1 |
| 10 | Crystallization damage by sodium sulfate 显示文摘 | Nicholas T Flatt R J Scherer G W | 2003 | J Cult Herit2003，4，10： | 1 |
| 11 | Head and neck lymphadenopathy:Evaluation with US-guided cutting-needle biopsy 显示文摘 | Nicholas J Screaton Laurence H Berman John W Grant | 2002 | Radiology2002，224，： | 1 |
| 12 | A Compilation of New and Published Major and Trace Element Data for NIST SRM 61- and NIST S 612 Glass Reference Materials 显示文摘 | Nicholas J G P William T P John A W | 1997 | Geostandards and Geoanalytical Research1997，，1： | 1 |
| 13 | Nitrogen fiation by lichens of arid zone crusts显示文摘 | Rogers R W Lange R T Nicholas D J D | 1966 | Nature1966，209，： | 1 |
| 14 | Intelligent Agents, Theory and Practice 显示文摘 | Michael W Nicholas R J | 1995 | Knowledge Engineering Review1995，10，2： | 1 |
| 15 | The effects of ten weeks of resistance and combined plyometric/sprint training with the meridian elyte athletic shoe on muscular performance in women显示文摘 | NICHOLAS A RATAMESS W J KRAEMER J S | | 0，，03： | 1 |
| 16 | Optical fiber long-period gratings with Langmuir-Blodgett thin-film overlays显示文摘 | Nicholas D R Stephen W J Ralph P T | 2002 | Optics Letters2002，27，9： | 1 |
| 17 | Roles for cyclopentenyl cations in the synthesis of hydrocarbons from methanol on zeolite catalyst HZSM-5显示文摘 | Haw J F Nicholas J B Song W G | 2000 | J Am Chem Soc2000，122，： | 1 |
| 18 | Roles for cyclopentenyl cations in the synthesis of hydrocarbons from methanol on zeolite catalyst HZSM-5 显示文摘 | HAW J F NICHOLAS J B SONG W | 2000 | J Am Chem Soc2000，122，： | 1 |
| 19 | Crystallization dam- age by sodium sulfate 显示文摘 | NICHOLAS T FLATT R J SCHERER G W | 2003 | Journai of Cultural Heritage2003，4，2： | 1 |
| 20 | Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea显示文摘 | Nicholas J Talley Eslie Helen Dennis V.Ann Schettler-Duncan Brian E Lacy Kevin W Olden Michael D Crowell | 2003 | The American Journal of Gastroenterology2003，，11： | 1 |
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