|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 2 | ‘Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘 | Nicholson L K Lindon J C Holmes E | 1999 | Xenobiotica1999，29，2： | 1 |
| 3 | Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)HNMR spectroscopy显示文摘 | Griffin J L Bollard M Nicholson J K | 2002 | NMR Biomed2002，15，6： | 1 |
| 4 | Anal Biochem显示文摘 | Gray M C Plant A L Nicholson J M May W E | | 224: 286-2920，224，： | 1 |
| 5 | CCR5 and CXCR4 expression on memory and naive T cells in HIV-1 infection and response to highly active antiretroviral therapy显示文摘 | NICHOLSON J K BROWNING S W HENGELR L | 2001 | J Acquir Immune Defic Syndr2001，27，2： | 1 |
| 6 | The utilization of bryophytes in bioclimatic modeling: predicted north- ward migration of peatlands in the Mackenzie River basin, Canan- da, as a result of global warming显示文摘 | Gignac L Dennis Barbara J Nicholson Suzanne E Bayley | 1998 | The Bryologist1998，101，： | 1 |
| 7 | Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies显示文摘 | Stoger E Vaquero C Tortes E Sack M Nicholson L Drossard J Williams S Keen D Perrin Y Christou P and Fischer R | 2000 | Plant Molecular Biology2000，42，： | 1 |
| 8 | Analysis of factors associated complications following renal transplant needle core biopsy 显示文摘 | Beckingham I J Nicholson M L Bell P R | 1994 | Br J Urol1994，73，1： | 1 |
| 9 | A research - basedsibling visitation program for theneonatal ICU显示文摘 | Montgomery L Kleiber C Nicholson A j | 1997 | Crit CareNurse1997，17，8： | 1 |
| 10 | Physiological variation in metabolic phenotyping and functional genomic studies:use of orthogonal signal correction and PLS-DA显示文摘 | Gavaghan C L Wilson I D Nicholson J K | 2002 | FEBS Lett2002，530，13： | 1 |
| 11 | Yield and nutritive val- ue of corn, barley, wheat, and forage oats as silage for lactating dairy cows 显示文摘 | Burgess P L Nicholson J W G Grant E A | 1973 | Canadian Journal of Animal Science1973，53，2： | 1 |
| 12 | cDNA cloning of a sorghum pathogenesis-related protein (PR-10) and differential expression of defense-related genes following inoculation with Cochliobolus heterstrophus or Colletotrichum sublineolum显示文摘 | Clive L S C Hipskind J D Nicholson R L | 1999 | Molecular Plant-microbe Interactions1999，12，6： | 1 |
| 13 | Role of the spore coat layers in Bacillus subtilis resistance to hydrogen peroxide,artificial UV-C,UV-B,and solar radiation显示文摘 | Riesenman P J Nicholson W L | 2000 | Applied and Environmental Microbiology2000，66，： | 1 |
| 14 | The effect of dexmedetomidine on agitation during weaning of mechanical ventilation in critically ill patients显示文摘 | Shehabi Y Nakae H Hammond N Bass F Nicholson L Chen J | 2010 | Anaesthesia and Intensive Care2010，，1： | 1 |
| 15 | Molecular analysis of the anaerobic rumen fungus Orpinomyces-insights into an AT-rich genome显示文摘 | Nicholson M J Theodorou M K Brookman J L | 2005 | Microbiology2005，151，： | 1 |
| 16 | Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic devel- opment and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms 显示文摘 | Yang L V Nicholson R H Kaplan J | 2001 | MechDev2001，104，12： | 1 |
| 17 | Active management of risk in pregnancy at term in an urban population: an association between a higher induction of labor rate and a lower cesarean deliveur rate显示文摘 | Nicholson J M Kellar L C Cronholm P F | 2004 | Am J Obstet Gynecol2004，191，5： | 1 |
| 18 | Prediction of deep reservoir quality from early diagenetic process models in the Jurassic eolian Norphlet Formation, Gulf of Mexico显示文摘 | Ajdukiewiez J M Nicholson P H Eseh W L | 2010 | AAPG Bulletin2010，94，： | 1 |
| 19 | Separation and quantification of cyclic hydroxamic acids and related compounds by high-pressure liquid chromatography显示文摘 | Lyons P C Hipskind J D Wood K V Nicholson R L | | 0，，： | 1 |
| 20 | Outsourcing Inventory Manage- ment Decisions in Healtheare: Models and Application显示文摘 | Nicholson L Vakhafia A J Erenguc S | 2004 | European Journal of Operational Research2004，154，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员