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| 1 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 2 | Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics显示文摘AIM:To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis(SBP). METHODS: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records. Each underwent a routine assessment prior to their paracentesis consisting of a complete blood count, complete metabolic profile and prothrombin time/international normalized ratio(INR) determination. The ascitic fluid was cultured and a complete cellcount and albumin determination was obtained on the fluid. In addition, blood and ascitic fluid was assessed for the levels of interleukin interleukin(IL)-1A, IL-1B, IL-2, IL-4, IL-8, IL-10, monocyte chemotactic protein(MCP)-1, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) utilizing the Randox Biochip platforms(Boston, MA). A serum-ascites gradient, for each cytokine and growth factor was calculated. The results are reported as mean ± SEM between disease groups with statistical analysis consisting of the student t-test(two tailed) with a P value of 0.05 defining significance. RESULTS: No clinically important demographic or biochemical differences between the 4 groups studied were evident. In contrast, marked difference in the cytokine and growth factors levels and pattern were evident between the 4 disease groups. Individuals with alcoholic cirrhosis had the highest levels of IL-1A, IL-1B, IL-4, IFNγ. Those with malignant disease had the highest levels of IL-2. Those with hepatitis C virus(HCV) associated cirrhosis had the highest value for IL-6, IL-8, IL-10, MCP-1 and VEGF. Those with cardiac disease had the highest level of TNF-α and EGF. The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8, IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease. CONCLUSION: These data document important differences in the cytokine and growth factor levels in plasma, ascitic fluid and the calculated plasma- ascites fluid gradients in cirrhotics requiring a large volume paracentesis. These differences may be important in determining the risk for bacterial peritonitis. | Bashar M Attar Magdalena George Nicolae Ion-Nedelcu Guilliano Ramadori David H Van Thiel | 2014 | World Journal of Hepatology2014，6，2： | 3 |
| 3 | Spontaneous bacterial peritonitis prevalence in pretransplant patients and its effect on survival and graft loss post-transplant显示文摘AIM To investigate the incidence of spontaneous bacterial peritonitis(SBP) in pre-transplant patients and its effect on post transplant mortality and graft failure. METHODS We conducted a retrospective cohort study of patient records from the organ procurement and transplant network data set. Patients were identified by the presence of SBP pre-transplant. Univariate post-transplant survival models were constructed using the Kaplan-Meier technique and multivariate models were constructed using the Cox proportional hazards model. Variables that affected post-transplant graft survival were identified in the SBP population. RESULTS Forty-seven thousand eight hundred and eighty patient records were included in the analysis for both groups, and 1966(4.11%) patients were identified in the data set as having pre-transplant SBP. Patients that had pre-transplant SBP had higher rates of graft loss from recurrent hepatitis C virus(HCV)(3.6% vs 2.0%, P < 0.0001), infections leading to graft loss(1.9% vs 1.3%, P = 0.02), primary non-function(4.3% vs 3.0%, P < 0.0001) and chronic rejection(1.1% vs 0.7%, P = 0.04). Kaplan-Meier survival analysis showed a statistically significant difference in all-cause survival in patients with a history of SBP vs those without(P < 0.0001). Pretransplant history of SBP was independently predictiveof mortality due to recurrent HCV(HR = 1.11, 95%CI: 1.02-1.21, P < 0.017) after liver transplantation.CONCLUSION HCV patients prior to the advent of directing acting anti-viral agents had a higher incidence of pre-transplant SBP than other patients on the liver transplant wait list. SBP history pre-transplant resulted in a higher rate of graft loss due to recurrent HCV infection and chronic rejection. | Neeral L Shah Nicolas M Intagliata Zachary H Henry Curtis K Argo Patrick G Northup | 2016 | World Journal of Hepatology2016，8，36： | 2 |
| 4 | An Assessment of Ad- vanced Mobile Services Acceptance: Contributions from TAM and Diffusion Theory Models 显示文摘 | Nicolas C L Castillo F J M Bouwman H | 2008 | Information & Management2008，45，6： | 1 |
| 5 | Calcium oscillations in higher plants显示文摘 | Nicola H Evans Martin R McAinsh Alistair M Hetherington | 2001 | Current Opinion in Plant Biology2001，，5： | 1 |
| 6 | Temporal and light-based changes in carbon uptake and storage in the spring ephemeral Podophyllum peltatum (Berberidaceae) 显示文摘 | Constable J V H Peffer B J De Nicola D M | 2007 | Environmental and Experimental Botany2007，60，1： | 1 |
| 7 | Long-term renewal of hair follicles from clonogenic multipotent stem cells显示文摘 | Claudinot S Nicolas M Oshima H | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 8 | A primer on newborn screening显示文摘 | Kristin G B Kimberly M H Nicola L | 2004 | Advances in Neonatal Care2004，4，5： | 1 |
| 9 | Regulation of enterobacterial cephalosporinase production : the role of a membrane - bound sensory transducer显示文摘 | Hanore N Nicolas M - H Cole ST | 1989 | Molecular Microbiology1989，3，8： | 1 |
| 10 | Endothelin and endothelin receptors in the renal and cardiovascular systems 显示文摘 | NICOLAS V SUSI H TAKASHI M | 2012 | Life Sci2012，91，1314： | 1 |
| 11 | Shear force detection by using bimorph cantilever with the enhanced Q factor显示文摘 | Lei F H Nicolas J L Troyon M | 2003 | Journal of Applied Physics2003，93，4： | 1 |
| 12 | Green fluorescent protein as a quantitative tool显示文摘 | Nicola J Hack Brian Billups Peter B Guthrie John H Rogers Elizabeth M Muir Thomas N Parks Stanley B Kater | 2000 | Journal of Neuroscience Methods2000，，2： | 1 |
| 13 | Solubility and emulsifying properties of caseins and whey proteins modifi ed enzymatically by trypsin显示文摘 | CHOBERT J M CATHERINE B H NICOLAS M G | 1988 | J Agric and Food Chem1988，36，： | 1 |
| 14 | Solubility and emulsifying properties of casein and whey proteins modified enzymatically by trypsin显示文摘 | J M Chobert B H Catherine M G Nicolas | 1988 | Joumal of Agriculture and Food Chemistry1988，36，5： | 1 |
| 15 | Unsupervised synthetic aperture radar image segmentation using fisher distributions显示文摘 | Galland F Nicolas J M Sportouche H | 2009 | IEEE Transactions on Geoscience and Remote Sensing2009，47，8： | 1 |
| 16 | Systemic lupus erythematosus features in rheumatoid arthritis and their effect on overall mortality 显示文摘 | Icen M Nicola PJ Maradit-Kremers H | 2009 | J Rheumatol2009，36，1： | 1 |
| 17 | Joint moving cast shadows segmentation and light source detection in video sequences显示文摘 | Nicolas H Pinel J M | 2006 | Signal Processing:Image Communication2006，21，1： | 1 |
| 18 | Effect of turgor on micromechanical and structural properties of apple tissue: A quantitative analysis显示文摘 | OEY M L VANSTREELS E DE BAERDEMAEKER J RAMON H HERTOG M L A T M NICOLA B | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 19 | Continuous prediction of spontaneous affect from multiple cues and modalities in valence-arousal space 显示文摘 | Nicolaou M A Gunes H Pantic M | 2011 | IEEE Trans on Affective Computing2011，2，2： | 1 |
| 20 | Effect of germination on chemical composition, biochemical constituents and antinutritional factors of soyabean seeds显示文摘 | Ban H M Villaume C Nicolas J P | 1997 | Journal of science of Food and Agricuture1997，73，： | 1 |
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