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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Simultaneous nitrification and denitrification in aerobic chemostat culture of Thiosphaera patotropha显示文摘 | ROBERTSON L A VAN NIEL E W J TORREMANS R A M | 1988 | Applied Environmental Microbiology1988，54，11： | 1 |
| 3 | Simultaneous nitrification and denitrification in aerobic chemostat cultures of Thiosphaera pantotropha 显示文摘 | Robertson L A van Niel Ed W J Torremans ROB A M | 1988 | Appl Environ Microbiol1988，54，11： | 1 |
| 4 | Telemedieal treatment at home of diabetic显示文摘 | Jane C Simon B L Niels E | 2005 | Journal of Telemedicine and Telecare2005，11，2： | 1 |
| 5 | Rolling - circle amplification of Torque teno virus ( TTV ) complete genomes from human and swine sera and identification of a novel swine TTV genogroup 显示文摘 | NIEL C DINIZ - MENDES L DEVALLE S | 2005 | J Virol2005，86，： | 1 |
| 6 | Simultaneous Nitrification and Denitrification in Aerobic Chemostat Cultures of Thiosphaeera Pantotropha显示文摘 | L A Robertson ED W J VAN Niel ROB A M Torremans | 1988 | Applied and Environmental Microbiology1988，54，11： | 1 |
| 7 | Simultaneous nitrification and denitrification aerobic chemostat cultures of thiosphaera pantotropha显示文摘 | Robertson L A Van Niel E W J | 1998 | Applied Environmental Microbiology1998，54，1： | 1 |
| 8 | Simultaneous nitrification and denitrifica2tion in aerobic chemostat cultures of Thiosphaera pantotropha 显示文摘 | Robertson L A Van Niel E W J Torremans R A M Kuenen J G | 1988 | Appl Envir Microbiol1988，54，11： | 1 |
| 9 | Blood glucose and cerebrovascular disease in nondiabetic patients显示文摘 | Niel L Heming RM | 2007 | Angiology2007，58，5： | 1 |
| 10 | Rolling-circle amplification of torque teno virus (TTV)complete genomes from human and swine sere and identification of a novel swine TTV genogroup显示文摘 | Niel C Diniz-Mendes L Devalle S | 2005 | J Gen Virol2005，86，5： | 1 |
| 11 | Effects ofsediment burial on tropical ruderal seagrasses aremoderated by clonal integration 显示文摘 | Ooi J L S Kendrick G A van Niel K P | 2011 | Cont Shelf Res2011，31，： | 1 |
| 12 | Model-based design of horizontal subsurface flow constructed treatment wetlands:a review显示文摘 | Diederik P L R Peter A V Niels D P | 2004 | Water Research2004，38，5： | 1 |
| 13 | Waist circumference as a measurement of obesity in the Netherlands Antilles ; associations with hypenension and diabetes mellitus显示文摘 | Grievink L Alberts JF O'Niel J | 2004 | Eur J Clin Nutr2004，58，8： | 1 |
| 14 | Rolling-circle amplification of Torque teno virus(TTV) complete genomes from human and swine sera and identification of a novel swine TTV genogroup显示文摘 | Niel C Diniz-Mendes L Devalle S | 2005 | J Gen Virol2005，86，5： | 1 |
| 15 | Schulz Ecological footprint time series of Austria,the Philippines and South korea for 1961-1999 comparing the conventional approach to an actual land area approach显示文摘 | Mathis Wackernagel ChadMonfreda karl-Heinz Erb HelmutHaber l Niels B | 2004 | Land Use Policy2004，2，13： | 1 |
| 16 | Developing a decision support tool for China's re-vegetation program:Simulating regional impacts of afforestation on average streamflow in the Loess Plateau 显示文摘 | McVicar T R Li L Niel T | 2007 | Forest Ecol Manage2007，251，： | 1 |
| 17 | Simultaneous nitrification and denitrification in aerobic chemostat culture of Thiosphaera patotropha 显示文摘 | Robertson L A Niel E W Torremans R M | 1988 | Appl Environ Microbiol1988，54，11： | 1 |
| 18 | Electron microscopic immunocytochemical demonstration of blood retinal barrier breakdown in human diabetics and its association with aldose reductase in retinal vascular endothelium and retinal pigment epithelium显示文摘 | Vinores S A Van Niel E Swerdloff J L Campochiaro P A | 1993 | Histochem J1993，25，： | 1 |
| 19 | Rolling-circle am- plification of Torque teno virus (TTV) complete ge- nomes from human and swine sera and identification of a novel swine TTV genogroup显示文摘 | Niel C Diniz-Mendes L Devalle S | 2005 | J Gen Virol2005，86，： | 1 |
| 20 | Simultaneous nitrification and denitrification in aerobic ehemostat cultures of thiosphaera pantotropha显示文摘 | Robertson L A Niel E W Torremans R A | 1988 | Applied and Environmental Micro- biology1988，54，11： | 1 |
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