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| 1 | CloudRank-D: benchmarking and ranking cloud computing systems for data processing applications显示文摘与信息的爆炸生长,越来越多的组织正在部署私人云系统或租公共的云系统处理大数据。然而,为在整个系统水平上评估云性能没有存在基准套房。就我们的知识而言,这份报纸建议第一基准套房 CloudRank-D 到计算为运行大数据应用程序被分享的系统的基准和等级云。我们分析以前的度量标准的限制,例如,浮点操作为评估一个云计算系统,并且建议二个简单度量标准:每秒处理的数据和为评估作为二个互补度量标准每朱尔处理的数据遮蔽计算系统。我们详细说明那认为应用程序,数据特征的差异,和应用程序和系统软件平台的动态行为代表性的 CloudRank-D 的设计。通过实验,我们表明我们的建议度量标准的优点。在几案例研究,我们用 CloudRank-D 评估云计算系统的二小规模的推广。 | Chunjie LUO Jianfeng ZHAN Zhen JIA Lei WANG Gang LU Lixin ZHANG Cheng-Zhong XU Ninghui SUN | 2012 | Frontiers of Computer Science2012，6，4： | 5 |
| 2 | EFFECTS OF RETINOIC ACID ON PROLIFERATION AND DIFFEREN-TIATION OF A HUMAN OVARIAN CARCINOMA CELL LINE:3AO显示文摘Objective To observe the effects of retinoic acid (RA) on the proliferation and differentiation of a human ovarian carcino-ma cell line: 3AO cells. Methods 3AO cell proliferation was evaluated by viable cell count, percentage of cells in each cycle phase were analyzed by flow cytometric analysis, alkaline phosphatase (AKP) activity was determined as described , and CA125 expression was measured by ELISA. Results RA could inhibit the proliferation of 3AO cells accompanied with morphological changes in a dose-dependent manner. Cell cycle analysis indicated that RA inhibition of 3AO cells growth occurred through induction of G1 arrest with a concomitant reduction in the proportion of cells in S phase, AKP activity increased significantly after treatment with RA(0.1 μmol/L) for 1-5 days. Dose-response studies revealed that the AKP activity increased to a different extent as a function of RA concentrations. Furthermore, RA could suppress the expression of CA125 tumor marker in 3AO cells.Conclusion RA could markedly inhibit the proliferation and induce the differentiation of 3AO cells. for 1-5 days. | Ming-JuanXu YingCui NingHui Yu-JianLiu | 2005 | Chinese Medical Sciences Journal2005，20，1： | 3 |
| 3 | Multiple olfactory pathways contribute to the lure process of Caenorhabditis elegans by pathogenic bacteria显示文摘Chemosensation is indispensable for the survival of Caenorhabditis elegans to discriminate food and pathogenic bacteria in their living environment. Food-like odors emitted by the pathogen Bacillus nematocida B16 for trapping its hosts and an olfactory signaling pathway responsible to sense the attractant 2-heptanone were identified in our previous study. Here, we further explore how the worms recognize the attractive molecules indole and 2-ethyl hexanol, which have different chemical properties and modest nematode-luring ability. We show that the chemotaxis toward indole and 2-ethyl hexanol requires the G protein-coupled receptors encoded by str-193 on AWC and str-7 on AWA. In a further genetic screen for downstream effectors in olfactory signaling cascades, the Gα subunit GSA-1, guanylyl cyclase ODR-1 and DAF-11 and the c GMP-gated channel TAX-2/TAX-4 were found to be necessary for indole sensation, whereas the TRPV channels OSM-9/OCR-2 and the PLC pathway activated by GPA-6 are responsible for the detection of 2-ethyl hexanol. Altogether, our current work further clarifies the distinct olfactory signaling pathways through which C. elegans senses different chemicals and is lured by B. nematocida B16, improving our comprehensive understanding of the mechanisms by which bacterial pathogens effectively infect their hosts. | Man Zhu Yao Chen Ninghui Zhao Hua Bai Keqin Zhang Xiaowei Huang | 2021 | Science China(Life Sciences)2021，64，8： | 2 |
| 4 | PD-1 Involvement in Peripheral Blood CD8+T Lymphocyte Dysfunction in Patients with Acute-on-chronic Liver Failure显示文摘Background and Aims:Programmed cell death-1(PD-1)plays an important role in downregulating T lymphocytes but the mechanisms are still poorly understood.This study aimed to explore the role of PD-1 in CD8^(+)T lymphocyte dysfunction in hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).Methods:Thirty patients with HBV-ACLF and 30 healthy controls(HCs)were recruited.The differences in the numbers and functions of CD8^(+)T lymphocytes,PD-1 and glucose transporter-1(Glut1)expression from the peripheral blood of patients with HBV-ACLF and HCs were analyzed.In vitro,the CD8^(+)T lymphocytes from HCs were cultured(HC group)and the CD8^(+)T lymphocytes from ACLF patients were cultured with PD-L1-IgG(ACLF+PD-1 group)or IgG(ACLF group).The numbers and functions of CD8^(+)T lymphocytes,PD-1 expression,glycogen uptake capacity,and Glut1,hexokinase-2(HK2),and pyruvate kinase(PKM2)expression were analyzed among the HC group,ACLF group and ACLF+PD-1group.Results:The absolute numbers of CD8^(+)T lymphocytes in the peripheral blood from patients with HBVACLF were lower than in the HCs(p<0.001).The expression of PD-1 in peripheral blood CD8^(+)T lymphocytes was lower in HCs than in patients with HBV-ACLF(p=0.021).Compared with HCs,PD-1 expression was increased(p=0.021)and Glut1 expression was decreased(p=0.016)in CD8^(+)T lymphocytes from the HBV-ACLF group.In vitro,glycogen uptake and functions of ACLF CD8^(+)T lymphocytes were significantly lower than that in HCs(p=0.017;all p<0.001).When PD-1/PD-L1 was activated,the glycogen uptake rate and expression levels of Glut1,HK2,and PKM2 showed a decreasing trend(ACLF+PD-1 group compared to ACLF group,all p<0.05).The functions of CD8^(+)T lymphocytes in the ACLF+PD-1 group[using biomarkers of Ki67,CD69,IL-2,interferon-gamma,and tumor necrosis factor-alpha-were lower than in the ACLF group(all p<0.05).Conclusions:CD8^(+)T lymphocyte dysfunction is observed in patients with HBV-ACLF.PD-1-induced T lymphocyte dysfunction might involve glycolysis inhibition. | Xiaoshuang Zhou Yidong Li Yaqiu Ji Tian Liu Ninghui Zhao Jiefeng He Jia Yao | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 2 |
| 5 | Fabrication of Regular Hierarchical Structures with Superhydrophobic and High Adhesion Performances on a 304 Stainless Steel Surface via Picosecond Laser显示文摘Hierarchical structures significantly influence the development of metal surface wettability.In this study,three kinds of hierarchical structures fbimed by the superimposition of different nanoscale(quasi-)periodic structures on micro-column arrays were fabricated on 304 stainless steel surfaces via picosecond laser irradiation.Scanning Electron Microscope(SEM)and Confocal Laser Scanning Microscope(CLSM)were used to characterize the created hierarchical structures.An optical contact angle meter was used to analyse the wetting performances.The results show that the surfaces of these fabricated samples have superhydrophobic properties and strong adhesion per formances,which can be attributed to the formation of hierarchical structure that causes a reduction in the liquid-solid contact area and the change in the direction of surfece tension.By controlling the dimensionof the nanotextures on the micro-column arrays,the hydrophobic property of 304 stainless steel surfaces can be greatly improved. | Chenbin Ma Min Kang Xingsheng Wang Ninghui Li Wei Hong Chenyu Li An Yang | 2019 | Journal of Bionic Engineering2019，16，5： | 2 |
| 6 | Delegation Logic:A Logic-based Approach to Distributed Authorization显示文摘 | Ninghui Li Benjamin N G Feigenbaum J | 2003 | ACM Transactions on Information and System Security2003，6，1： | 1 |
| 7 | Experimental research about the role of activating water-vapor in the De SO2technology from flue gas with PPCP显示文摘 | WU Yan LI Jie WANG Ninghui | 2000 | IEEE Industry Applications Conference2000，，： | 1 |
| 8 | SO2 Removal from Industrial Flue Gases Using Pulsed Corona Discharge显示文摘 | Wu Yan Wang Ninghui Zhu Yimin | 1998 | Journal of Electrostatics1998，44，： | 1 |
| 9 | Industrial experiments on desulfurization of flue gases by pulsed corona induced plasma chemical process显示文摘 | Wu Yan Li Jie Wang Ninghui | 2003 | Journal of Electrostatics2003，57，34： | 1 |
| 10 | Study on Increasing the SO2 Removal Efficiency with the Radicals Produced by H2O in Pulse Discharge Plasma Process显示文摘 | Wu Yan Li Jie Wang Ninghui | 2001 | Jpn J Appl Phys:Part 22001，40，8： | 1 |
| 11 | Delegation logic: A logic-based approach to distributed authorization显示文摘 | LI NINGHUI GROSOF B N FEIGENBAUM J | 2003 | ACM Transaction on Information and System Security2003，6，1： | 1 |
| 12 | OACerts:oblivious attribute certificates 显示文摘 | Li Jiangtao Li Ninghui | 2006 | IEEE Transactions on Dependable and Secure Computing2006，3，4： | 1 |
| 13 | Industrial experiments on desulfurization of flue gas by pulsed corona induced plasma chemical process显示文摘 | Yan Wu Jie Li Ninghui Wang | 2003 | Journal of Electrostatics2003，57，34： | 1 |
| 14 | Industrial experiments on desulfurization of flue gases by pulsed corona induced plasma chemical process显示文摘 | Yan Wu Jie Li Ninghui Wang | 2003 | Journal of Electrostatics2003，57，： | 1 |
| 15 | Distributed credential chain discovery in trust management显示文摘 | LI NINGHUI WINSBOROUGH W H MITCHELL J C | 2003 | Journal of Computer Security2003，11，1： | 1 |
| 16 | Blend Films of Chitosan/Starch显示文摘BlendFilmsofChitosan/StarchDuYumin,XiaZuyong,LuRongDepartmentofEnvironmentalScience,WuhanUniversity,Wuhan430072,ChinaAbstract... | Song Yunchun Ren Nan Mao Ninghui Liu Lihua | 1997 | Wuhan University Journal of Natural Sciences1997，2，2： | 1 |
| 17 | Slicing: A new approach for privacy preserving data publishing 显示文摘 | Ninghui Li Jian Zhang Molloy I | 2009 | 1EEE Transactions onKnowledge and Data Engineering2009，24，3： | 1 |
| 18 | Towards optimal k-anonymization显示文摘 | Tiancheng Li Ninghui Li | 2008 | Data and Knowledge Engineering2008，65，1： | 1 |
| 19 | Closeness: a new privacy measure for data publishing显示文摘 | Li Ninghui Li Tiancheng Venkatasubramanian S | 2010 | IEEE Trans on Knowledge and Data Engineering2010，22，7： | 1 |
| 20 | Nickel-Catalyzed Cross-Coupling of Aryl Pivalates with Cyclobutanols Involving C-O and C-C Bond Cleavage显示文摘of main observation and conclusion An efficient nickel-catalyzed cross-coupling of aryl pivalates with cyclobutanols is described.The use of Ni(cod)2/PCy3/base as the catalytic system enables the cleavage of inert C—0 bond and C—C bond under mild conditions,thus providing a facile access to y-arylated ketones in generally good to excellent yields.This transformation is also characterized by wide substrate scope and functional group compatibility,for example,methoxy,γ-dimethylamino,keto,ester,fluoro and TMS groups are well-tolerated during the reaction process. | Yi Gan Ninghui Zhang Shaoxu Huang Yuanhong Liu | 2020 | Chinese Journal of Chemistry2020，38，12： | 1 |
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