|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Snapshot of HIV pathogenesis in China显示文摘Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy na?ve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area. | Nitin K SAKSENA Bin WANG Megan STEAIN Rong Ge YANG Lin Qi ZHANG | 2005 | Cell Research2005，15，11： | 4 |
| 3 | Unique case of oligoastrocytoma with recurrence and grade progression:Exhibiting differential expression of high mobility group-A1 and human telomerase reverse transcriptase显示文摘Mixed gliomas, primarily oligoastrocytomas, account for about 5%-10% of all gliomas. Distinguishing oligoastrocytoma based on histological features alone has limitations in predicting the exact biological behavior, necessitating ancillary markers for greater specificity. In this case report, human telomerase reverse transcriptase(hT ERT) and high mobility group-A1(HMGA1); markers of proliferation and stemness, have been quantitatively analyzed in formalin-fixed paraffin-embedded tissue samples of a 34 years old patient with oligoastrocytoma. Customized florescence-based immunohistochemistry protocol with enhanced sensitivity and specificity is used in the study. The patient presented with a history of generalized seizures and his magnetic resonance imaging scans revealed infiltrative ill-defined mass lesion with calcified foci within the left frontal white matter, suggestive of glioma. He was surgically treated at our center for four consecutive clinical events. Histopathologically, the tumor was identified as oligoastrocytoma-grade Ⅱ followed by two recurrence events and final progression to grade Ⅲ. Overall survival of the patient without adjuvant therapy was more than 9 years. Glial fibrillary acidic protein, p53, Ki-67, nuclear atypia index, pre-operative neutrophillymphocyte ratio, are the other parameters assessed. Findings suggest that hT ERT and HMGA1 are linked to tumor recurrence and progression. Established markers can assist in defining precise histopathological grade in conjuction with conventional markers in clinical setup. | Puneet Gandhi Richa Khare Kavita Niraj Nitin Garg Sandeep K Sorte Hanni Gulwani | 2016 | World Journal of Clinical Cases2016，4，9： | 2 |
| 4 | Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients显示文摘BACKGROUND Inflammation is crucial to tumor progression.A traumatic event at a specific site in the brain activates the signaling molecules,which triggers inflammation as the initial response within the tumor and its surroundings.The educated immune cells and secreted proteins then initiate the inflammatory cascade leading to persistent chronic inflammation.Therefore,estimation of the circulating inflammatory indicators kynurenine(KYN),interleukin-6(IL-6),tissue-inhibitor of matrix-metalloproteinase-1 and human telomerase reverse transcriptase(hTERT)along with neutrophil-lymphocyte ratio(NLR)has prognostic value.AIM To assess the utility of chosen inflammatory marker panel in estimating systemic inflammation.METHODS The chosen markers were quantitatively evaluated in 90 naive,molecularly subtyped plasma samples of glioma.A correlation between the markers and confounders was assessed to establish their prognostication power.Follow-up on the levels of the indicators was done 3-mo post-surgery.To establish the validity of circulating KYN,it was also screened qualitatively by dot-immune-assay and by immunofluorescence-immunohistochemistry in tumor tissues.RESULTS Median values of circulating KYN,IL-6,hTERT,tissue-inhibitor of matrixmetalloproteinase-1 and NLR in isocitrate-dehydrogenase-mutant/wildtype and within the astrocytic sub-groups were estimated,which differed from controls,reaching statistical significance(P<0.0001).All markers negatively correlated with mortality(P<0.0001).Applying combination-statistics,the panel of KYN,IL-6,hTERT and NLR achieved higher sensitivity and specificity(>90%)than standalone markers,to define survival.The inflammatory panel could discriminate between WHO grades,and isocitrate-dehydrogenase-mutant/wildtype and define differential survival between astrocytic isocitrate-dehydrogenase-mutant/wildtype.Therefore,its assessment for precise disease prognosis is indicated.Association of KYN with NLR,IL-6 and hTERT was significant.Cox-regression described KYN,IL-6,NLR,and hTERT as good prognostic markers,independent of confounders.Multivariate linear-regression analysis confirmed the association of KYN and hTERT with inflammation marker IL-6.There was a concomitant significant decrease in their levels in a 3-mo follow-up.CONCLUSION The first evidence-based study of circulating-KYN in molecularly defined gliomas,wherein the tissue expression was found to be concomitant with plasma levels.A non-invasive model for assessing indicators of chronic systemic inflammation is proposed. | Puneet Gandhi Richa Shrivastava Nitin Garg Sandeep K Sorte | 2021 | World Journal of Clinical Oncology2021，12，10： | 2 |
| 5 | A programmable cascaded low-pass filter-based flux synthesis for a stator flux-oriented vector-controlled induction motor drive显示文摘 | Bose Bimal K Patel Nitin R | 1997 | IEEE Transactions on Industrial Electronics1997，，： | 1 |
| 6 | An infrared spectroscopy study of the hydrogen bonding and water restructuring as a trisiloxane superspreading surfactant adsorbs onto an aqueous hydrophobic surface 显示文摘 | NITIN K CHARL E M ALEXANDER C | 2006 | Colloids Surf A2006，210，： | 1 |
| 7 | Fluorine-doped TiO2 powders prepared by spray pyrolysis and their improved photocatalytic activity for decomposition of gas-phase acetaldehyde显示文摘 | Di Li Hajime Haneda Shunichi Hishita Naoki Ohashi Nitin K Labhsetwar | 2005 | J Fluorine Chem2005，126，： | 1 |
| 8 | Optimum design of double pipe heat exchanger显示文摘 | Prabhata K Swamee Nitin Aggarwal Vijay Aggarwal | 2008 | International Journal of Heat and Mass Transfer2008，51，： | 1 |
| 9 | A hybrid wavelet-ELM based short term price forecasting for electricity mar- kets 显示文摘 | NITIN A S BIJAYA K P | 2014 | Electrical Power and Energy Systems2014，55，： | 1 |
| 10 | Cross-linked guar gum microspheres a viable approach for improved delivery of anticancer drugs for the treatment of colorectal cancer显示文摘 | Mohini C Manish K C Nitin K J | 2006 | AAPS Pharm Sci Tech2006，7，3： | 1 |
| 11 | Numerical Investigation of Three-dimensional Natural Circulation Phenomenon in Passive Safety Systems for Decay Heat Removal in Large Pools 显示文摘 | Nitin M Jyeshtharaj B J Arun K N | 2015 | International Journal of Heat and Mass Transfer2015，81，2： | 1 |
| 12 | Removal of orange-G and methyl violet dyes by adsorption onto bagasse fly ash-ki- netic study and equilibrium isotherm analyses显示文摘 | INDRA D M VIMAL C S NITIN K A | 2006 | Dyes and Pigments2006，69，3： | 1 |
| 13 | Removal of orange-G and methyl violet dyes by adsorption onto bagasse fly ash-kinetic study and equilibrium isotherm analyses 显示文摘 | Indra D Mall Vimal C Srivastava Nitin K Agarwal | 2006 | Dyes and Pigments2006，69，3： | 1 |
| 14 | Influence of fly ash on strength behavior of typical soils 显示文摘 | J Prabakar Nitin Dendorkar P K Morchhale | 2004 | Construction and Building Materials2004，18，4： | 1 |
| 15 | Ultrasensitive DNA sequence detection using nanoscale ZnO sensor arrays 显示文摘 | Nitin K Adam D Jong-In H | 2006 | Nanotechnology2006，17，12： | 1 |
| 16 | Thermal and Struc- tural Analysis of MIG for Gyrotron显示文摘 | Udaybir S Anil K Nitin K etal | 2011 | J Fusion Energ2011，30，1： | 1 |
| 17 | Removal of orange-G and methyl violet dyes by adsorption onto bagasse fly ash-kinetic study and equilibrium isotherm analyses显示文摘 | Indm D Mall Vimal C Srivastava Nitin K Agarwal | 2006 | Dyes and Pigments2006，69，3： | 1 |
| 18 | Nuclear matrix protein 22 as adjunct to urine cytology and cystoscopy in follow-up of superficial TCC of urinary bladder显示文摘 | Narmada PG Nitin S Rajeev K | 2009 | Urology2009，73，： | 1 |
| 19 | Experimental Study of Non-Boiling Heat Transfer from a Horizontal Surface by Water Sprays 显示文摘 | Nitin K Sunil R K Subbarao P M V | 2007 | Experimental Thermal and Fluid Science2007，32，2： | 1 |
| 20 | A Programmable Cascaded Low Pass Filter Based Flux Synthesis for a Stator Flux Oriented Vector Con- trolled Induction Motor Drive 显示文摘 | Bimal K Bose Nitin R Patel | 1997 | IEEE Transactions on Industrial Electronics1997，44，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员