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1Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified.Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer 2016World Journal of Gastroenterology2016,22,13:9
2Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein 1998The Lancet . 1998 (9106)1998,,9106:2
3The long-term pathological evolution of chronic hepatitis C显示文摘M Yano H Kumada M Kage K Ikeda K Shimamatsu O Inoue E Hashimoto JH Lefkowitch J Ludwig K Okuda 1996Hepatology1996,,6:2
4Sizing and Geometry Optimization of Cable-stayed Bridges 显示文摘Simōes LMC Negrǎo JH 1994Comquters and Structures1994,52,:2
5Diagnosis of pancreatic injury:a need to improveperformance显示文摘Dondelinger RF Boverie JH Comet O 2000JBR-BTR2000,83,4:1
6The prevalence of diabetic retinopathy among adults in the United States显示文摘Kempen JH O' Colmain B J Leske MC 2004Arch Ophthalmol2004,122,:1
7Osteoprotegerin ligand regulates osteodast adherence to the bone sur{ace in mouse calvaria显示文摘O' Brien EA Wdliams JH Marshall MJ 2000Biochem Biophys Res Commun2000,274,2:1
8Intensity of renal support in itically ill patients with acute kidney injury 显示文摘Palevsky PM Zhang JH O' Connor TZ 2008N Engl J Med2008,359,6:1
9Production of bacterial cellulose by a static cultivation using the waste from beer culture broth显示文摘HA JH SHEHZAD O KHAN S 2008Kor J Chem Eng2008,25,4:1
10Induction chemotherapy with cisplatin and fluomuracil alone or in combination with do- cetaxel in locally advanced squamous-cell cancer of the head and neck : long - term results of the TAX 324 randomised phase 3 trial 显示文摘Lorch JH Goloubeva O Haddad RI 2011The Lancet Oncology2011,12,2:1
11Alcohol and cardiovascularhealth the razor-sharp double-edged sword显示文摘O’Keefe JH Bybee KA Lavie CJ 2007J Am Coll Cardiol2007,50,11:1
12Osteopretegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria显示文摘O'Brien EA Williams JH Marshall MJ 2000Biochem Biophys Res Commun2000,274,2:1
13Implantation of scleral-flxated posterior chamber intraocular lenses in adults 显示文摘Kjeka O Bohnstedt J Meberg K Seland JH 2008Acta Ophthalmologica2008,86,5:1
14Primary T-cell lymphoma of the breast:a case report显示文摘Briggs JH Algan O Stea B 0,,01:1
15Tackling antibiotic resistance显示文摘Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr 0,,:1
16The novel apolipoprotein A5 is present in human serum,is associated with VLDL,HDL,and chylomicrons,and circulates at very low concentrations compared with other apolipoproteins显示文摘O′Brien PJ Alborn WE Sloan JH 0,,02:1
17Bypass surgery versus coronary angioplasty for revascularization of treated diabetic patients 显示文摘Gum PA O'Keefe JH Borkon AM 1997Circulation1997,96,9:1
18Rapid esterasesensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokineties of docetaxel and metabolites in mice 显示文摘van Tellingen O Beijnen JH Verweij J 1999Clin Cancer Res1999,5,10:1
19Predictors of adverse outcome in cancer patients with candidemia显示文摘Anaissie EJ Rex JH Uzun O 1998Am J Med1998,104,:1
20Fatigue in the general Norwegianpopulation:normative data and associations显示文摘Loge JH Ekeberg O Kaasa S 1998J Psychosom Res1998,45,:1
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