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31篇 您的检索式:作者名="OBACH R"
    题名 作者 年代 出处 被引量
1The prediction of human pharmacokinetic parameters from pre clinical and in vitro metabolism data显示文摘Obach R S Baxter J G Listen T E 1997J Pharmacol Exp Ther1997,283,:1
2Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the alpha-synuclein gene in early onset patients显示文摘MUNOZ E OLIVA R OBACH V MARTI M J PASTOR P BALLESTA F TOLOSA E 1997Neuroscience Letters1997,235,12:1
3Pharmacologically active drug metabolites:impact on drug discovery and pharmacotherapy 显示文摘Obach R 2013Pharmacol Rev2013,65,2:1
4Metabolic charac- terization of the major human small intestinal cytochrome p450s显示文摘OBACH R S ZHANG Q Y DUNBAR D 2001Drug Metab Dispos2001,29,3:1
5Validated Assays for Human Cytochrome P450 Activities显示文摘Walsky Robert L Obach R Scott 2004Drug Metabolism Disposition2004,32,6:1
6Measurement of Michaelis Constants for Cytochrome P450-Mediated Biotransformation Reactions Using A Substrate Depletion Approach显示文摘Obach R Scott Reed-Hagen Anne E 2002Drug MetabolismDisposition2002,30,7:1
7Validated assays for human cytochrome P450 activities 显示文摘WALSKY R L OBACH R S 2004Drug Metabolism and Disposition2004,32,6:1
8The Prediction of Human Pharmacokinetic Parameters from Preclinical and in Vitro Metabolism Data显示文摘Obach R Scott Baxter James G Liston Theodore E 1997The Journal of Pharmacology and Experimental Therapeutics1997,283,1:1
9Validated assays for human eytoehrome P45o activities 显示文摘WALSKY R L OBACH R S 2004Drug Metab Dispos2004,32,6:1
10The utility of in vitro cytochrome CYP inhibition data in the prediction of drug-drug interactions显示文摘Obach R S Walsky R L Venkatakrishnan K 2006J Pharmacol Exp Ther2006,316,:1
11A comparation in vitro of transdermal absorption of a series of calcium antagonist显示文摘Diez H Colon R Obach 1991J Pharm Sci1991,80,10:1
12The prediction human pharma-cokinetic parameters from preclinical and in vitro metabolism data显示文摘Obach R S Baxter J G Liston T E 1997J Pharmacol Exp Ther1997,283,1:1
13Validated assays for human cyto- chrome P450 activities 显示文摘ROBERT L W OBACH R S 2004Drug Metab Disp2004,32,6:1
14Validated assays for human cyto- chrome P460 activities显示文摘Walsky R L Obach R S 2004Drug Metab Dispos2004,32,6:1
15A comprehensive listing of bioactivation pathways of organic functional groups显示文摘KALGUTKAR A S GARDNER I OBACH R S 2005Curr Drug Metab2005,6,3:1
16Effect of dietary conjugated linoleic acid(CLA)on lipid composition,metabolism and gene expression in Atlantic salmon(Salmo salar)tissues显示文摘Leaver M J Tocher D R Obach A 2006Comparative Biochemistry and Physiology-Part A:Molecular & Integrative Physiology2006,145,2:1
17Can in vitro metabolism-dependent covalent binding data in liver micro- somes distinguish hepatotoxic from nonhepatotoxic drugs? An a- nalysis of 18 drugs with consideration of intrinsic clearance and daily dose 显示文摘OBACH R S KALGUTKAR A S SOGLIA J R 2008Chem Res Toxicol2008,21,9:1
18Drug metabolism and drug interactions :application and clinical value of in vitro models 显示文摘Venkatakrishnan K Moltke L L Obach R S 2003Current Drug Metabolism2003,4,5:1
19Mechanism-Based inactivation of human cytochrome P450 enzymes and the prediction of drug-drug interactions 显示文摘Venkatakrishnan K Obach R S Rostami-Hodjegan A 2007Xenobiotica2007,37,1011:1
20Validated assays for human cytochrome P450 activities 显示文摘WALSKY R L OBACH R S 2004Drug Metab Dispos2004,32,6:1
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