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| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 2 | Cranio-facial morphology of adult unoperated complete unilateral cleft lip and palate patients显示文摘 | Capelozza L Jr Taniguchi SM da Silva OG Jr | 1993 | Cleft Palate Craniofac J1993，30，： | 1 |
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| 6 | Pharmacokinetics,pharmacodynamics,and safety of exenatide in patients with type 2 diabetes mellitus显示文摘 | Kolterman OG Kim DD Shen L | | 0，，02： | 1 |
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| 11 | Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus显示文摘 | Kolterman OG Kim DD Shen L | 2005 | Am J Health Syst Pharm2005，62，2： | 1 |
| 12 | Rescue of influenza A virus from recombinant DNA显示文摘 | Fodor E Devenish L Engelhardt OG | 1999 | J Virol1999，73，11： | 1 |
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| 14 | Prediction of death in patients with primary intracerebral hemorrhage : a prospective study of a defined population 显示文摘 | Nilsson OG Lindgren A Brandt L | 2002 | J Neurosurg2002，97，3： | 1 |
| 15 | Influence of lip repair on craniofacial morphology of patients with complete bilateral cleft lip and palate 显示文摘 | Da Silva Filho OG Valladares Neto J Capelloza Filho L | 2003 | Cleft Palate Craniofac J2003，40，2： | 1 |
| 16 | Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration 显示文摘 | Nilsson OG Brandt L Ungerstedt U | 1999 | Neurosurgery1999，45，5： | 1 |
| 17 | Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus 显示文摘 | Kolterman OG Kim DD Shen L | 2005 | Am J Health Syst Pharm2005，62，2： | 1 |
| 18 | Trandolapril reduces the incidence of atrial fibrillation after acuter myocardial infarction in patients with left ventricular dysfunction显示文摘 | Bagger H Kober L | 1999 | Circulation1999，100，： | 1 |
| 19 | Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium显示文摘 | Maisnier-Patin S Berq OG Liljas L | 2002 | Mol Microbiol2002，46，2： | 1 |
| 20 | Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus 显示文摘 | Kolterman OG Kim DD Shen L | 2005 | Am Health Syst Pharm2005，62，2： | 1 |
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