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| 1 | 腺病毒介导的抗MDR1核酶基因转移联合化疗药物治疗恶性淋巴瘤的研究显示文摘目的 探讨腺病毒介导的抗MDR1核酶基因转移在体内外逆转肿瘤细胞中P 糖蛋白(P gp)介导的多重耐药性 (MDR)的作用。方法 构建并纯化制备了含有抗MDR1核酶基因的腺病毒Ad 196MDR1 Rz。在体外 ,用该重组腺病毒转导具有P gp介导的、MDR特性的人淋巴瘤细胞株Daudi MDR2 0 ,并分别用RT PCR、FACS分析和MTT法测定核酶基因转导对Daudi MDR2 0细胞MDR1mRNA和膜表面P gp表达的影响及对长春新碱 (VCR)敏感性的改变 ;在体内 ,通过局部注入重组腺病毒联合VCR全身化疗 ,对接种Daudi MDR2 0细胞的SCID小鼠进行治疗观察。结果 在感染Ad 196MDR1 Rz后 ,Daudi MDR2 0细胞MDR1mRNA的表达被阻断 ,细胞膜表面P gp表达水平显著降低 ,细胞对VCR的敏感性增加。在接种Daudi MDR2 0细胞后 ,采用Ad 196MDR1 Rz联合VCR化疗的治疗组小鼠有6 6 .7% (6 9)未发生肿瘤 ,存活时间超过 12 0d ;而采用空载腺病毒联合VCR化疗或单纯VCR化疗的对照组小鼠 ,其长期存活率分别为 12 .5 % (1 8)和 0 (0 9) ,两组差异有极显著性。结论 Ad 196MDR1 Rz能有效阻断Daudi MDR2 0细胞膜表面P gp表达 ,并恢复肿瘤细胞对VCR的敏感性。体内联合VCR化疗能有效抑制肿瘤的发生。 | 徐东平 王福生 Takao Ohnuma 金磊 | 2002 | 中华肿瘤杂志2002，24，6： | 4 |
| 2 | Cementite decomposition in heavily drawn pearlite steel wire显示文摘 | K Hono M Ohnuma M Murayama S Nishida A Yoshie T Takahashi | 2001 | Scripta Materialia2001，，： | 2 |
| 3 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 4 | Sterol constituents from five edible mushrooms显示文摘 | Yaoita Y Amemiya K Ohnuma H | 1998 | Chemical & Pharmaceutical Bulletin1998，46，6： | 1 |
| 5 | Microstructures and magnetic properties of Co-Al-O granular thin films显示文摘 | OHNUMA M HONO K ONODETA H OHNUMA S FUJIMORI H PEDERSEN J S | 2000 | J Appl Phys2000，87，2： | 1 |
| 6 | Tumor suppressor in lung cancer-1 as a novel amelo-blast adhesion molecule and its downreg-ulation in ameloblastoma显示文摘 | Usami Y Ito A Ohnuma K Fuku T | 2007 | Pathol Int2007，57，2： | 1 |
| 7 | 显示文摘 | Takahashi Y K Ohnuma M | 2002 | J Magn Magn Mater2002，246，12： | 1 |
| 8 | Thermodynamic database on microsolders and copper-based alloy systems显示文摘 | X. J. Liu I. Ohnuma C. P. Wang M. Jiang R. Kainuma K. Ishida M. Ode T. Koyama H. Onodera T. Suzuki | 2003 | Journal of Electronic Materials2003，，11： | 1 |
| 9 | Phase equilibria in the Ti–Al binary system显示文摘 | I Ohnuma Y Fujita H Mitsui K Ishikawa R Kainuma K Ishida | 2000 | Acta Materialia2000，，12： | 1 |
| 10 | Ongoing subclinical infection of hepatitis E virus a- mong blood donors with an elevated alanine amin- otransferase level in Japan显示文摘 | Gotanda Y Iwata A Ohnuma H Yoshikawa A Mizoguchi H Endo K Takahashi M Okamoto H | 2007 | Journal of Medical Vi- rology2007，79，6： | 1 |
| 11 | Radial displacement of the medial meniscus in varus osteoarthritis of the knee显示文摘 | Sugita T Kawamata T Ohnuma M | 2001 | Clin Orthop Relat Res2001，，387： | 1 |
| 12 | 显示文摘 | Eldrup M Pedersen A Ohnuma M | 2000 | Mater Sci Forum2000，，： | 1 |
| 13 | Radial displacement of the medial meniscus in varus osteoarthritis of the knee 显示文摘 | Sugita T Kawamata T Ohnuma M | 2001 | Clin Orthop Relat Res2001，，387： | 1 |
| 14 | A new method for the quantitative analysis of the scale and composition of nanosized oxide in 9Cr-ODS steel显示文摘 | M. Ohnuma J. Suzuki S. Ohtsuka S.-W. Kim T. Kaito M. Inoue H. Kitazawa | 2009 | Acta Materialia2009，，18： | 1 |
| 15 | Tunneltype GMR in Co-Al-O insulated granular system-Its oxygen-concentration dependence 显示文摘 | FUJIMORI H MITANI S OHNUMA S | 1996 | J Magn Magn Mater1996，156，2： | 1 |
| 16 | Nano structure of rapidly quenched Cu-(Zr or Hf)-Ti alloys and their devitrification process显示文摘 | Saida J Osuna T Ohnuma M Matsubara E Inoue A | 2003 | Sci Technol Adv Mater2003，4，： | 1 |
| 17 | Cobalt-base high-temperature alloys显示文摘 | SATO J OMORI T OIKAWA K OHNUMA I KAINUMA R | 2006 | Science2006，312，： | 1 |
| 18 | Study of early pregnancy factor(EPF) in equine (Equus caballus)显示文摘 | Ohnuma K Yokoo M Ito K | | 0，，： | 1 |
| 19 | Thermodynamic database for phase diagrams in micro-soldering alloys显示文摘 | I. Ohnuma X. J. Liu H. Ohtani K. Ishida | 1999 | Journal of Electronic Materials1999，，11： | 1 |
| 20 | FeCo-Zr-O nanogranular soft-magnetic thin films with a high magnetic flux density显示文摘 | Fujimori H Masumoto T | 2003 | Appl Phys Lett2003，82，6： | 1 |
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