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| 1 | Non-invasive biomarkers for monitoring the fibrogenic process in liver:A short survey显示文摘The clinical course ofchronic liver diseases is significantly dependent on the progression rate and the extent offibrosis, i.e. the non-structured replacement of necrotic parenchyma by extracellular matrix. Fibrogenesis, i.e. the development offibrosis can be regarded as an unlimited wound healing process, which is based on matrix (connective tissue) synthesis in activated hepatic stellate cells, fibroblasts (fibrocytes), hepatocytes and biliary epithelial cells, which are converted to matrix-producing (myo-)fibroblasts by a process defined as epithelial-mesenchymal transition. Blood (noninvasive) biomarkers offibrogenesis and fibrosis can be divided into class and class analytes. Class biomarkers are those single tests, which are based on the pathophysiology offibrosis, whereas class biomarkers aremostly multiparametric algorithms, which have been statistically evaluated with regard to the detection and activity ofongoing fibrosis. Currently available markers fulfil the criteria ofideal clinical-chemical tests only partially, but increased understanding ofthe complex pathogenesis offibrosis offers additional ways for pathophysiologically well based serum (plasma) biomarkers. They include TGF-β-driven marker proteins, bone marrow-derived cells (fibrocytes), and cytokines, which govern proand anti-fibrotic activities. Proteomic and glycomic approaches ofserum are under investigation to set up specific protein or carbohydrate profiles in patients with liver fibrosis. These and other novel parameters will supplement or eventually replaceliver biopsy/histology, high resolution imaging analysis, and elastography for the detection and monitoring of patients at risk ofdeveloping liver fibrosis. | Axel M Gressner Chun-Fang Gao Olav A Gressner | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 2 | Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein显示文摘AIM:To investigate the mechanisms involved in a possible modulator role of interleukin(IL) -6 signalling on CYR61-CTGF-NOV(CCN) 2/connective tissue growth factor(CTGF) expression in hepatocytes(PC) and to look for a relation between serum concentrations of these two parameters in patients with acute inflammation. METHODS:Expression of CCN2/CTGF,p-STAT3,p-Smad 3/1 and p-Smad2 was examined in primary freshly isolated rat or cryo-preserved human PC exposed to various stimuli by Western blotting,electrophoretic mobility shift assay(EMSA) ,reporter-gene-assays and reversetranscriptase polymerase chain reaction. RESULTS:IL-6 strongly down-regulated CCN2/CTGF protein and mRNA expression in PC,enhanceable by extracellular presence of the soluble IL-6 receptor gp80,and supported by an inverse relation between IL-6 and CCN2/CTGF concentrations in patients'sera.The inhi-bition of TGFβ1 driven CCN2/CTGF expression by IL-6 did not involve a modulation of Smad2(and Smad1/3) signalling.However,the STAT3 SH2 domain binding peptide,a selective inhibitor of STAT3 DNA binding activity,counteracted the inhibitory effect of IL-6 on CCN2/CTGF expression much more pronounced than pyrrolidine-dithiocarbamate,an inhibitor primarily of STAT3 phosphorylation.An EMSA confirmed STAT3 binding to the proposed proximal STAT binding site in the CCN2/CTGF promoter. CONCLUSION:CCN2/CTGF is identified as a hepatocellular negative acute phase protein which is downregulated by IL-6 via the STAT3 pathway through interaction on the DNA binding level. | Olav A Gressner Ieva Peredniene Axel M Gressner | 2011 | World Journal of Gastroenterology2011，17，2： | 3 |
| 3 | Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells显示文摘瞄准:学习 C (CysC ) ,它由转变生长 factor-beta1 (TGF-beta1 ) 的规定和导出血小板的生长因素(PDGF ) 和有在这个特殊房间发信号的 TGF-beta1 的 CysC 的潜在的干扰打的 cystatin 的表示。方法:我们计算了 CysC 表达式在有教养, profibrogenic 肝的星形细胞和区分 trans 的 myofibroblasts 由北、西方弄污并且共焦的激光扫描显微镜学。结果:CysC 在 trans 区别期间显著地被增加。TGF-beta1 和 PDGF-BB 压制了 CysC 表示。而且, CysC 分泌物被处理与 TGF-beta1 导致。尽管 CysC 导致了 TGF 贝它的一种增加的有约束力的亲密关系,受体是由化学 cross-linking 估计了与打 III (beta-glycan )[125I ] 它没调制的 -TGF-beta1, 由评估 Smad2/3 磷酸化地位出现的 TGF-beta1 信号转导变异并且[CAGA ]-MLP-luciferase 记者基因试金。有趣地,流类型 III TGF 贝它受体 beta-glycan 在对待 CysC 的房间被减少。我们的数据显示那 CysC 表情起来在 trans 区别期间调整了。结论:在患肝疾病的病人的浆液的增加的 CysC 层次是至少部分由于在激活的肝的星形细胞的更高的表情。而且, TGF-beta1 影响 CysC 的分泌物,加亮在肝的纤维发生的前进的半胱氨酸朊酶的一个潜在地重要的角色。 | Axel M Gressner Birgit Lahme Steffen K Meurer Olav Gressner Raif Weiskirchen | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 4 | Intrauterine devices-upper and lower genital tract infectious显示文摘 | | 2007 | Contraception2007，75，6： | 1 |
| 5 | Reduction of truncation er- rors in planar near- field aperture antenna measurements using the gerchberg - papoulis algorithm 显示文摘 | ENRICA M OLAV B STEFANO M | 2008 | IEEE Transactions on Antennas and Propagation2008，56，11： | 1 |
| 6 | Synthesis and characterization of hydrophohically modified poly (vinylalcohol) 显示文摘 | Olav M Jaan R | 1999 | Polymer Bulletin1999，42，5： | 1 |
| 7 | Probabilistic a-nalysis of characteristic pressure for LNG tanks显示文摘 | MATEUSZ G TORGEIR M OLAV R | 2006 | Jour-nal of Offshore Mechanics and Arctic Engineering2006，128，13： | 1 |
| 8 | Mutual vulnerability, mutual dependence: the reflexive relation be- tween human society and the environment显示文摘 | FRASER E D G WARREN M OLAV S | 2003 | Global Environmental Change2003，13，： | 1 |
| 9 | Screening of Biomark ers in Rat Urine Using LC/ Electrospray Ionization-MS and Two-Way Data Analysis 显示文摘 | Helena I B Edlund P O Olav M | 2003 | Anal Chem2003，75，： | 1 |
| 10 | Screening of Biomarkers in Rat Urine Using LCP Electrospray Ionization-MS and Two-Way Data Analysis显示文摘 | HELENA I B EDLUND P O OLAV M | 2003 | Anal Chem2003，75，： | 1 |
| 11 | Low-dose preoperative radiation postpones recurrences in operable rectal cancer显示文摘 | Olav D Arild H Inge M | 1990 | Cancer September1990，66，： | 1 |
| 12 | Unwanted incidents during transition of geriatric patients from hospital to home: a prospective observational study显示文摘 | Marianne M Jorunn L Olav S | 2010 | BMC Health Services Research2010，10，1： | 1 |
| 13 | Anaerobic ammonium oxidation by anammox bacteria in the Black Sea显示文摘 | Kuypers M M M Olav Sliekers A Lavik G | 2003 | Nature2003，422，6932： | 1 |
| 14 | Key site variables governing the functional characteristics of Dissolved Natural Organic Matter (DNOM) in Nordic forested catchments显示文摘 | Rolf D. Vogt Jarkko Akkanen Dag Olav Andersen Rainer Brüggemann Bimal Chatterjee Egil Gjessing Jussi V. K. Kukkonen H?kon E. Larsen J?rg Luster Andrea Paul Stephan Pflugmacher Mike Starr Christian E. W. Steinberg Philippe Schmitt-Kopplin ádám Zsolnay | 2004 | Aquatic Sciences2004，，2： | 1 |
| 15 | Calcium alginate gel fiber:Influence of alginate source and gel structure on fiber strength显示文摘 | STORKER M GUDMUND S B OLAV S | 1994 | Applied Polymer Sci1994，51，： | 1 |
| 16 | Distribution patterns of the muscular branch of the median nerve in the thenar region显示文摘 | Olave E Prates JC Del Sol M | 1995 | J Anat1995，186，： | 1 |
| 17 | Synthesis and characterization of hydrophobically modified poly (vinyl alcohol)显示文摘 | Olav M Jaan R | 1999 | Polymer Bulletin1999，42，5： | 1 |
| 18 | Ge-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca2+ -dependent interaction with the megalin/gp330 receptor显示文摘 | Olav A Gressner Birgit Lahme Axel M Gressner | 2008 | Clinica Chimica Acta2008，390，1： | 1 |
| 19 | Biomass productionfrom the microalga Phaeodactylum tricornutum :Nutrient stress and chemical composition in exponentialfed-batch cultures 显示文摘 | Chauton M S Olsen Y Olav V | 2013 | Biomass and Bioenergy2013，58，： | 1 |
| 20 | Simulation can help optimize drilling and cut costs显示文摘 | Geir Hareland Paul R Olav M | 2000 | Drilling Contractor2000，56，6： | 1 |
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