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| 1 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 2 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 3 | The cancer/testis genes:review,standardization,and commentary显示文摘 | Simpson A J Old L J | 2004 | Cancer Immunity2004，4，： | 1 |
| 4 | Selective etching of semicrystalline polymers:CF4 gas plasma treatment of poly (ethylene)显示文摘 | Olde Riekerink M B Terlingen J G A Engbers G H M | 1999 | Langmuir1999，15，14： | 1 |
| 5 | Enhanced secretion of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and soluble LAIR-1 in rheumatoid arthritis显示文摘 | Olde Nordkamp M J van Roon JA Douwes M | 2011 | Arthritis Rheum2011，63，12： | 1 |
| 6 | Selective etching of semicrystalline polymers: CF4 gas plasma treatment of poly(ethylene) 显示文摘 | Olde Riekerink M B Terlingen J G A Engbers G H M | 1999 | Langmuir1999，15，14： | 1 |
| 7 | Vibrational spectroscopy for cancer diagnostics 显示文摘 | Old O J Fullwood L M Scott R | 2014 | Anal Meyhods2014，6，： | 1 |
| 8 | Risk factors which predispose first-time traumatic anterior shoulder dislocations to recurrent insta- bility in adults : a systematic review and meta-analysis显示文摘 | Olds M Ellis R Donaldson K | 2015 | Br J Sports Med2015，49，14： | 1 |
| 9 | Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states显示文摘 | Old E A Malcangio M | 2012 | Curr Opin Pharmacol2012，12，： | 1 |
| 10 | The cancer/testis genes:review,standardization,and commentary显示文摘 | SCANLAN M J SIMPSON A J OLD L J | 2004 | Cancer Im-mun2004，4，： | 1 |
| 11 | Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas显示文摘 | Suijkerbuijk RF Olde Weghuis DE Van den Berg M | 1994 | Genes Chromosomes Cancer1994，9，4： | 1 |
| 12 | Rapid evolution of cancer/testis genes on the X chromosome显示文摘 | Stevenson BJ Iseli C Panji S Zahn-Zabal M Hide W Old LJ Simpson AJ Jongeneel CV | 2007 | BMC Genomics2007，8，： | 1 |
| 13 | Ceramic sol gel composite coatings for electrical insulation显示文摘 | Olding T Saycr M Barrow D | 2001 | Thin Solid Films2001，，： | 1 |
| 14 | Screening and genetic diagnosis of haemoglobin disor- ders显示文摘 | OLD J M | 2003 | Blood Rev2003，17，1： | 1 |
| 15 | Simultaneous humoral and cellular immune response against cancer-testis antigen NYESO-hdefinition of human histocompatibility leukocyte antigen (HLA) -A2-binding peptide epitopes 显示文摘 | J ger E Chen YT Drijfhout JW Karbach J Ringhoffer M Jager D Arand M Wada H Noguchi Y Stockert E Old LJ Knuth A | 1998 | J Exp Med1998，187，： | 1 |
| 16 | The cancer/testis genes:review,standardization,and commentary显示文摘 | SCANLAN M J SIMPSON A J OLD L J | 2004 | Cancer Immun2004，23，： | 1 |
| 17 | Electronic media use and adolescent health andwell-being:cross-sectional community study显示文摘 | MATHERS M CANTERFORD L OLDS T | 2009 | AcadPediatr2009，9，5： | 1 |
| 18 | Population - based pervalence of symptomatic and asymptomatic astrovirus infection in rural Mayan infants显示文摘 | Maldonado Y Cantwell M Old M | 1998 | J Infect Dis1998，178，： | 1 |
| 19 | Hepatitis B vaccine as a cause of false positive hepatitis B surface antigen 显示文摘 | OLDE C GARICIA M | 1998 | J Cannt1998，8，4： | 1 |
| 20 | Chemokine mediated neuron-gila commu- nication and aberrant signalling in neuropathic pain states 显示文摘 | Old EA Malcangio M | 2012 | Curr Opin Pharmacol2012，12，1： | 1 |
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