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| 1 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | Early and late complications of double pigtail ureteral stent显示文摘 | Damiano R Oliva A Esposito C | 2002 | Urol Int2002，69，2： | 1 |
| 3 | Nonlinear MPC for the airflow in a PEM fuel cell using a Volterra series model 显示文摘 | Gruher J K Bordons C Oliva A | 2012 | Control Engineering Practice2012，20，2： | 1 |
| 4 | Reversible silencing of CFTR chloride channels by glutathionylation显示文摘 | Wang W Oliva C Li G | 2005 | J Gen Physiol2005，125，2： | 1 |
| 5 | Accuracy of the Rotfinder instrument in detecting decay on Norway spruce trees显示文摘 | OLIVA J ROMERALO C STENLID J | 2011 | Forest Ecology and Management2011，262，8： | 1 |
| 6 | Parametric studies on automotive radiators 显示文摘 | OLIET C OLIVA A CASTRO J | 2007 | Applied Thermal Engineer- ing2007，27，12： | 1 |
| 7 | Soluteaccumulation and distribution during shoot and leafdevelopment in two sorghum genotypes under salt stress显示文摘 | Lacerda C F Cambraia J Oliva M A | 2003 | Environ Exp Bot2003，49，2： | 1 |
| 8 | Nonlinear MPC for the airflow in a PEM fuel cell using a Volterra series model显示文摘 | Gruber J K Bordons C Oliva A | 2012 | Control Engineering Practice2012，20，2： | 1 |
| 9 | Antioxidant activities and oxidative stress byproducts in human hypertension 显示文摘 | Redon J Oliva MR Tormos C | 2003 | Hyperten- sion2003，41，5： | 1 |
| 10 | Catalysts for syndio- tactic-specific polymerization of styrene: A tentative interpreta- tion of some experimental data显示文摘 | Zambelli A Pellecchia C Oliva L | 1991 | Macromol Chem1991，192，2： | 1 |
| 11 | Conversion of olive tree biomass into fermentable sugars by dilute acid pretreatment and enzymatic saccharification 显示文摘 | Cara C Ruiz E Oliva J | 2008 | Bioresource Technology2008，99，6： | 1 |
| 12 | A community outbreak of Legionnaires' disease associated with a cooling tower in Vic and Gurb, Catalonia(Spain)in 2005显示文摘 | Ferré MR Arias C Oliva JM | 2009 | Eur J Clin Microbiol Infect Dis2009，28，2： | 1 |
| 13 | Photosyn2 thesis and activity of superoxide dismutase,peroxidase and glu- tathione reductase in cotton under salt stress 显示文摘 | Meloni D A Oliva M A Martinez C A | 2003 | Envi- ron Export2003，，69： | 1 |
| 14 | Photosynthesisand activity of superoxide dismutase, peroxidase and glutathionereductase in cotton under salt stress显示文摘 | MELONI D A OLIVA M A MARITINEZ C A | 2003 | Environmental and Ex-perimental Botany2003，49，： | 1 |
| 15 | Purifica- tion and properties of an aspartic protease from pota*o tuber that is inhibited by a basic chitinase 显示文摘 | Guevara M G Oliva C R Machinandiarena M | 1999 | Physiologia Planta- rum1999，106，2： | 1 |
| 16 | Purificationand Characterization of a new trypsin inhibitor fromDimorphandra mollis seeds显示文摘 | Mello G C Oliva M L Sumikawa J T | 2001 | Journal of proteinchemistry2001，20，8： | 1 |
| 17 | Early and late complications of double pigtail ureteral stent 显示文摘 | Damiano R Oliva A Esposito C | 2002 | Urol Int2002，69，2： | 1 |
| 18 | Urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma 显示文摘 | Ahmed N Riley C Oliva K | 2005 | British Journal of Cancer2005，92，： | 1 |
| 19 | Lymphocyte distribution and intrahepatic compartmentalization during HCV infection: a main role for MHC-unrestricted T cells 显示文摘 | Agrati C Nisli C Oliva A | 2002 | Arch Immunol Ther Exp2002，50，5： | 1 |
| 20 | Purification and charac terization of an aspartic protease from potato leaves 显示文摘 | Guevara M G Daleo G R Oliva C R | 2001 | Physiologia Plantarum2001，112，3： | 1 |
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