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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 3 | Montelukast improves pulmonary function measured by impulse oscillometry in children with asthma ( Mio study) 显示文摘 | Nieto A Pamies R Oliver F Medina A Caballero L Mazon A | 2006 | Respir Med2006，100，7： | 1 |
| 4 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 5 | Potential virulencefactors of Streptococcus dysgalactiae associated with bovinemastitis显示文摘 | Calvinho L F Almeida R A S P Oliver | 1998 | Vet Microbiol1998，61，： | 1 |
| 6 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 7 | The sitelocation of Zr atoms dissolved in TiAl显示文摘 | Chen X F Reviere R D Oliver B F | 1992 | Scripta METALLURGICA et Materia1992，27，： | 1 |
| 8 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 9 | Importance of poly(ADP-ribose)polymerse and its cleavage in apoptosis显示文摘 | Javier Oliver F Guadalupe R Veronique R | 2008 | Biochem Res2008，283，33： | 1 |
| 10 | A new approach for measurement of cytotoxicity using colorimetric assay显示文摘 | Hussain R F Nouri A M Oliver R T | 1993 | J Immunol Methods1993，160，1： | 1 |
| 11 | Densification of A1 powder and A1-Cu matrix composite (reinforced with 15 % Saffli short fibres) during axial cold compaction 显示文摘 | MORENO M F GONZ)tLEZ OLIVER C J R | 2011 | Powder Technology2011，206，： | 1 |
| 12 | Laparoscopic mamagement of presence of a significant haemoperitoneum显示文摘 | Rizzuto MI Oliver R Odejinmi F | 2008 | Arch Gynecol Obstet2008，277，5： | 1 |
| 13 | On the generality of the relationship among contact stiffness, contact area, and elastic modulus duringindentation显示文摘 | Pharr G M Oliver W C Brotzen F R | 1992 | JMater Res1992，7，3： | 1 |
| 14 | The use of car- bon substrate utilization patterns in environmental andecological microbiology 显示文摘 | Konopka A Oliver L Turco Jr R F | 1998 | Microbial Ecology1998，35，2： | 1 |
| 15 | V-Belt Life Prediction and Power Rating显示文摘 | Oliver L R Johnson C O Breig W F | | 0，，34： | 1 |
| 16 | Substitution behavior ofMn, Cr, and Zr in ternary and quaternary alloys ofTiAl显示文摘 | Reviere R D Chen X F Oliver B F | 1993 | Mater Sci Eng ( S0921-5093)1993，172，95： | 1 |
| 17 | 显示文摘 | Oliver R Ziyad M | 1995 | J Catal1995，157，： | 1 |
| 18 | A new approach for measurement of cytotoxicity using colorimetric assay 显示文摘 | Hussain R F Nouri A M Oliver R T | 1993 | J Immunol Methods1993，160，1： | 1 |
| 19 | T helper 1 and T helper 2 cells are pathogenic in an antigen specific model of colitis 显示文摘 | IQBAL N OLIVER J R WAGNER F H | 2002 | J Exp Med2002，195，1： | 1 |
| 20 | Processing and mechanical properties of in situ composites from the NiAI-Cr and the NiAl-(Cr, Mo) eutectic systems显示文摘 | Johnson D R Chen X F Oliver B F etal | 1995 | Intermetallics1995，3，： | 1 |
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