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| 1 | 铅对肾上腺皮质细胞线粒体的氧化损伤显示文摘【目的】研究铅对肾上腺皮质细胞氧化应激和线粒体功能的影响 ,为了解其肾上腺皮质毒作用机制提供依据。【方法】原代分离培养豚鼠肾上腺皮质细胞 ,以 0、6 2 5、12 5、2 5、5 0、10 0 μmol/L醋酸铅 (PbAc)处理细胞 ,观察PbAc诱导肾上腺皮质细胞活性氧 (ROS)产生和线粒体损伤作用。ROS检测采用荧光分光光度法 ,线粒体膜电位 (MMP)和细胞存活状态采用Rh12 3和PI双标记、流式细胞术检测 ,细胞ATP水平采用化学发光法测定。【结果】PbAc染毒后肾上腺皮质细胞ROS形成水平随剂量增加而增加 ,具有剂量效应关系 [^y=4 16 +10 2 1× 1g(x+1) ,P <0 0 1,R2 =0 6 41];线粒体膜电位呈剂量依赖性降低 ,Rh12 3的平均荧光强度 (MFI)在 6 2 5~ 10 0 μmol/L各剂量组依次为 1 0 1,0 94,0 96 ,0 95和 0 91,与对照组(1 35 )比较具有显著性差异 (P <0 0 1) ;染毒后细胞死亡率轻度增加 ,与对照组 (1 0 2 % )比较 ,5 0 μmol/L和 10 0 μmol/L的PbAc组分别为 3 16 %和 3 40 % ,差异具有显著性 (P <0 0 5 ) ;ATP水平降低与PbAc剂量之间存在剂量效应关系 [^y =2 12 96 5 7- 5 15 92 5× 1g(x +1) ,P <0 0 1,R2 =0 5 6 8],剂量和时间对ATP水平的影响呈协同抑制作用 (P <0 0 1)。【结论】线粒体氧化应激介导肾? | 杨杏芬 庄志雄 魏青 凌莉 范瑞泉 Shen H M Ong C N | 2001 | 中山医科大学学报2001，22，1： | 8 |
| 2 | 影响三地居民黄曲霉毒素B_1-白蛋白加合物的相关因素分析显示文摘[目的]分析影响存在肝癌发病率梯度的三地居民个体黄曲霉毒素生物效应的相关因素。[方法]对广西扶挼两个自然村农民、南宁和四川成都城市居民采用酶联免疫法检测血浆黄曲霉毒素B1-白蛋白加合物(AFB1-AlbuminAdducts,AAA)水平、肝炎病毒(hepatitisvirus,HV)标志物(HBV两对半,HCV、HDV、HEV和HGV抗体)及肝功能。[结果]扶挼47.2%(42/89)的居民至少1种HV感染标志物阳性;南宁和成都分别为15.8%(31/196)和22.7%(27/119)。Log(AAA)水平(n,x±s)为扶挼(89,2.44±0.16)和南宁(196,2.45±0.15)均高于成都(118,2.20±0.24),(P=0.000);但扶挼与南宁间差别无显著性(P=0.859)。南宁(P=0.023)、成都(P=0.026)两地男性AAA水平均高于女性。扶挼和成都两地HV感染者AAA水平均高于非感染者(P分别为0.447和0.041)。HV(-)组中,AAA水平与年龄(r=-0.199,P=0.000)和BMI(r=-0.158,P=0.006)负相关。HV(+)组AAA分别与白蛋白(P=0.000)、球蛋白(P=0.012)和天冬氨酸转氨酶(P=0.052)相关,而HV(-)组AAA分别与直接胆红素、间接胆红素、白蛋白、γ-谷氨酰转肽酶、总胆汁酸和碱性磷酸酶相关(P<0.05)。[结论]AFB1暴露的生物效应可能受肝炎病毒感染、性别、年龄和代谢等因素的影响。AAA与肝功能指标的相关性提示AFB1对肝脏实质或胆道细胞的损害作用。 | 彭涛 刘志明 刘唐威 黎乐群 秦雪 彭民浩 李佳荃 严律南 梁任祥 韦忠亮 Han-Ming Shen Ong Choon Nam LianWen Wang Qiao Wang Regina M Santella | 2005 | 环境与职业医学2005，22，3： | 3 |
| 3 | Resistance of fibre concrete slabs to low velocity projectile impact显示文摘 | Ong K C Baxkeerkhan M Paramasivam P | 1999 | Cement & Concrete Composites1999，21，4： | 2 |
| 4 | Interoperability of Design Intent in Integrated Product and Process Design显示文摘Concurrent engineering is currently an overwhelming t rend in product development since it takes the down-stream product development issues and product life-cycle issues into consideration in up-front design pro cess. At this stage, evaluation, verification and validation of design concepts and design schemes is critical to the right-to-market product development. I dentification and extraction of design intent from the part digital mock-ups in different data formats and created in different CAD systems for DFX considerati on, evaluation, verification, and validation is crucial too. Traditionally, fro m manufacturing point of view, feature identification and extraction is to get t he features and feature-related information for manufacturing planning and inte gration. Presently, from the viewpoint of product development and product servi ce life cycle, design intent identification and extraction is to get all the des ign-related information for DFX consideration in early design stage, such as de sign for assembly, design for service, design for tooling, design for functional ity and design for environment etc. Therefore, how to successfully extract desi gn intent such as design and machining features and design-related information from the prototyping digital mock-ups created by different CAD systems for DFX consideration in upstream design stage is a very useful topic in integrated prod uct and process design and development. Presently, there are heterogeneous CAD systems in the market and the interoperat ion among the different CAD systems is indispensable. The interoperability of d ifferent CAD systems is by way of data exchanged technology such as STEP and IGE S. The critical weakness of this interoperation technology is that much of the design intent is lost in the interoperation process. Once the product digital m ock-ups is exchanged via data exchange technology such as IGES or STEP, the des ign intent including the dimension-driven design features and other attributes embedded in the part model are lost in the data translation process. Models rea d out of CAD systems come into other systems as featureless chunks of geometry e ntities. Obviously, the interoperation technology does not satisfy the industry need. It has been reported that this poor interoperation technology, which pro vides poor CAD models in neutral-format geometry had cost the automobile indust ry alone $1 billon per year. Fortunately, some researchers have been aware of t he criticality of this since only the United States industry spends billons of d ollars as a result of poor interoperability between computer-aided engineering software tools. In the past, product development was often done within a single company by co-located design team. In more recent years, there has been a busi ness paradigm shift in product development as the product development is being d one more often by geographically and temporally distributed design teams. There is a high level of outsourcing, not only of manufacturing but also of actual pr oduct development effort. Besides, product development across companies, and ev en within a single company, is often done within a heterogeneous software tool e nvironment. How to improve the interoperability of design intent created in het erogeneous software tool environment geographically has become a critical issue in next-generation product development system. Design intent in this research is defined as the outcome of design process. Des ign process goes from the identification of needs to satisfaction of that needs. Design intent satisfies this kind of needs. In this research, design intent i s created in a CAD system and embedded in part CAD model. The detailed design i ntent here includes design and manufacturing features and the feature-relat ed information such as feature parameters, feature relationships and some relate d characteristics such as associativity. Interoperability refers to the ability to share and communicate in the heterogeneous environment or heterogeneous soft | M W Fu W F Lu A Y C Nee S K Ong | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 2 |
| 5 | Cellular retinoic acid-binding protein and the role of retinoic acid in the development of the chick embryo显示文摘 | Maden M Ong DE Summerbell D | 1989 | Dev Biol1989，135，： | 1 |
| 6 | Research frontier: memetic computation-past,present & future 显示文摘 | ONG Y S LIM M H CHEN Xian-shun | 2010 | IEEE Computational Intelli- gence Magazine2010，5，2： | 1 |
| 7 | Vena caval transection during retroperioneo copic nephrectomy: report of the complication and review of the literature显示文摘 | McAllister M Bhayani S B Ong A | 2004 | J Urol2004，172，： | 1 |
| 8 | Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia Miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells 显示文摘 | Liu J Shen H M Ong C N | 2001 | Life Sciences2001，69，16： | 1 |
| 9 | Asian medical staff attitudes to- wards witnessed resuscitation 显示文摘 | Ong M Chan Y Srither D | 2004 | Resuscitation2004，60，： | 1 |
| 10 | Vertebral artery domi- nance contributes to basilar artery culwatult and peri-verte brobasilar junctional infarcts显示文摘 | H ong J M Chung CS Bang OY | 2009 | J Neurol Neurosurg Psychia- try2009，80，： | 1 |
| 11 | An efficient method forcomputing leave-one-out error in support vector machines withgaussian kernels 显示文摘 | Lee M M S Keerthi S S Ong C J ei al | 2004 | IEEE Transition on Neural Networks2004，15，3： | 1 |
| 12 | Synthesis, characterization and comparative study of nano- Ag--TiO2 against Gram- positive and Gram- negative bacteria under fluorescent light 显示文摘 | BARUDIN N H A SREEKANTAN S ONG M T | 2014 | Food Control2014，，46： | 1 |
| 13 | Geographic-time distribution of ambulance calls in Singapore:utility of geographic information system in ambulance deployment (CARE 3)显示文摘 | ONG M E NG F S OVERTON J | 2009 | Ann Acad Med Singapore2009，38，3： | 1 |
| 14 | 显示文摘 | Ong H R Khan M R Chowdhury M N K | 2014 | Fuel2014，120，： | 1 |
| 15 | Cardiac arrest and resuscitation epidemiology in Singapore (CARE I study)显示文摘 | Eng Hock Ong M Chan Y H Anantharaman V | 2003 | Prehosp Emerg Care2003，7，4： | 1 |
| 16 | Six phase synchronous machine with AC and DC stator connections, Part Ⅰ and Part Ⅱ显示文摘 | Schiferl R F Ong C M | 1983 | IEEE Trans on PAS1983，102，8： | 1 |
| 17 | Texture determinants in cooked, parboiled rice Ⅰ: Rice starch amylose and the fine structure of amylopectin 显示文摘 | Ong M H Blanshard J M V | 1995 | J Cereal Sci1995，21，： | 1 |
| 18 | Short-and long-term clinical outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease:Insights from the rapamycin-eluting and taxus stent evaluated at rotterdam cardiology hospital registries (RESEARCH and T-SEARCH)显示文摘 | Valgimigli M van Mieghem CA Ong AT | 2005 | Circulation2005，111，： | 1 |
| 19 | An occlusal and eephalometric analysis of maxillary first and second premolar extraction effects 显示文摘 | Ong H B Woods M G | 2001 | Angle Orthod2001，71，2： | 1 |
| 20 | Public attitudes to e- mergency medical services in Singapore : EMS day 2002 显示文摘 | ONG M E H ANG P H Y CHAN Y H | 2004 | Singa- pore Med2004，45，9： | 1 |
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