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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review显示文摘Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chin ese Trauma Surge on Associati on orga nized a committee composed of 28 experts across China in July 2017, aiming to provide an evidence-based recommendation for the application of VSD in abdominal surgeries.Eleven questions regarding the use of VSD in abdominal surgeries were addressed:(1) which type of materials should be respectively chosen for the intraperitoneal cavity, retroperitoneal cavity and superficial incisions?(2) Can VSD be preventively used for a high-risk abdominal incision w让h primary suture?(3) Can VSD be used in severely contaminated/infected abdominal surgical sites?(4) Can VSD be used for temporary abdominal cavity closure under some special conditions such as severe abdominal trauma, infection, liver transplantation and intra-abdominal volume increment in abdominal compartment syndrome?(5) Can VSD be used in abdominal organ inflammation, injury, or postoperative drainage?(6) Can VSD be used in the treatment of intestinal fistula and pancreatic fistula?(7) Can VSD be used in the treatment of intra-abdominal and extra-peritoneal abscess?(8) Can VSD be used in the treatment of abdominal wall wounds, wound cavity, and defects?(9) Does VSD in crease the risk of bleeding?(10) Does VSD increase the risk of intestinal wail injury?(11) Does VSD increase the risk of peritoneal adhesion? Focusing on these questions, evidence-based recommendations were given accordingly. VSD was strongly recommended regarding the questions 2-4. Weak recommendations were made regarding questions 1 and 5-11. Proper use of VSD in abdominal surgeries can lower the risk of infection in abdominal incisions with primary suture, treat severely contaminated/infected surgical sites and facilitate temporary abdominal cavity closure. | Yang Li Pei-Yuan Li Shi-Jing Sun Yuan-Zhang Yao Zhan-Fei Li Tao Liu Fan Yang Lian-Yang Zhang Xiang-Jun Bai Jing-Shan Huo Wu-Bing He Jun Ouyang Lei Peng Ping Hu Yan-An Zhu Ping Jin Qi-Feng Shao Yan-Feng Wang Rui-Wu Dai Pei-Yang Hu Hai-Ming Chen Ge-Fei Wang Yong-Gao Wang Hong-Xu Jin Chang-Ju Zhu Qi-Yong Zhang Biao Shao Xi-Guang Sang Chang-Lin Yin | 2019 | Chinese Journal of Traumatology2019，22，1： | 26 |
| 3 | Principles,structures,and implementation of reconfigurable ternary optical processors显示文摘This paper discusses the principles,structures,and implementation procedures for reconfiguring a ternary optical processor (TOP).Typical structures,classifications,and naming of the TOP and basic operation units (BOUs) are described in this paper.The circuit implementations,commands,and processes for the reconfiguration are also discussed in detail.A simple analysis of the high performance and low power consumption of ternary optical computers is presented.Finally,an experiment is performed on reconfiguring a 1-bit BOU,which shows that the principles of reconfigurable TOPs are valid,and that the implementations and commands for the reconfiguration are effective. | JIN Yi WANG HongJian OUYANG shan ZHOU Yu SHEN YunPu PENG JunJie LIU XueMin | 2011 | Science China(Information Sciences)2011，54，11： | 23 |
| 4 | Serum levels of mi RNA in patients with hepatitis B virus-associated acute-on-chronic liver failure显示文摘Background: Hepatitis B virus(HBV)-associated acute-on-chronic liver failure(HBV-ACLF) is a lifethreatening condition and its exact pathophysiology and progression remain unclear. The present study aimed to assess the role of serum mi RNAs in the evaluation of HBV-ACLF and to develop a model to predict the outcomes for ACLF.Methods: Serum was collected from 41 chronic hepatitis B and 55 HBV-ACLF patients in addition to30 chronic asymptomatic HBV carriers as controls. The mi RNAs expressions were measured by real-time quantitative PCR(q-PCR). Statistical analyses were conducted to assess the ability of differentially expressed mi RNAs and other prognostic factors in identifying ACLF prognosis and to develop a new predictive model.Results: Real-time q-PCR indicated that serum miR-146 a-5 p, mi R-122-3 p and mi R-328-3 p levels were significantly upregulated in ACLF patients compared to chronic hepatitis B and chronic asymptomatic HBV carriers patients. In addition, multivariate regression analyses indicated that Na+, INR, gastrointestinal bleeding and mi R-122-3 p are all independent factors that are reliable and sensitive to the prognosis of HBV-ACLF. Therefore, we developed a new model for the prediction of HBV-ACLF disease state: Y = 0.402 × Na+-1.72 × INR-4.963 × gastrointestinal bleeding(Yes = 0; No = 1)-0.278 ×(mi R-122-3 p) + 50.449. The predictive accuracy of the model was 95.3% and the area under the receiver operating characteristic curve(AUROC) was 0.847.Conclusions: Expression levels of these mi RNAs(miR-146 a-5 p, mi R-122-3 p and mi R-328-3 p) positively correlate with the severity of liver inflammation in patients with ACLF and may be useful to predict HBV-ACLF severity. | Ya Wen Shi-Fang Peng Lei Fu Xiao-Yu Fu Da-Xian Wu Bing-Jie Liu De-Ming Tan Yi Ouyang | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，2： | 13 |
| 5 | Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma显示文摘包含蛋白质 1 的 Oxidored-nitro 领域(NOR1 ) 基因是首先从鼻咽的癌(NPC ) 孤立的新奇 nitroreductase 基因。它为它的 nitrosation 功能在化学致癌物的形成和 NPC 的 carcinogenesis 起一个重要作用。在鼻咽的癌细胞的野类型的 NOR1 基因的 Overexpression 是有效的禁止细胞生长和增长。在这研究,第一次,我们产生了高度特定的 NOR1 抗体并且在人的纸巾和 NPC 活体检视分析了 NOR1 分发。结果证明那 NOR1 蛋白质主要在人的鼻咽和气管的纸巾被表示。人的心,肝,怒气,胃,冒号,肾,骨胳的肌肉,胸腺,和胰都 NOR1 蛋白质是缺乏的。更重要地,我们在 NPC 纸巾执行了 NOR1 蛋白质表示的 immunohistochemistry 试金,并且结果证明那 NOR1 蛋白质在 NPC 经常是下面表示的。这些数据使 NOR1 的潜在的生理的函数的选择清楚些并且提供不可缺少的引用给 NPC 的 carcinogenesis 进程并且到识别或验证织物特定的药目标。 | Bo Xiang Mei Yi Li Wang Wei Liu Wenling Zhang Jue Ouyang Ya Peng Wenjuan Li Ming Zhou Huaying Liu Minghua Wu Rong Wan Xiaoling Li Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 10 |
| 6 | Anti-loosening performance of coatings on fasteners subjected to dynamic shear load显示文摘This paper investigates the self-loosening of threaded fasteners subjected to dynamic shear load. Three kinds of typical coatings, PTFE, MoS_2, and TiN applied to bolts and nuts, are tested in this investigation. The study experimentally examines the loosening mechanisms of fasteners and assesses the anti-loosening performance of the three tested coatings based on their tightening characteristics, loosening curves, and the damage of thread surface. Additionally, the anti-loosening performance of the three coatings is compared under different load forms. The results indicate that the PTFE and MoS_2 coatings have significant anti-loosening effect, whereas the anti-loosening performance of Ti N coating is not satisfactory. It is also found that an appropriate increase of the initial tightening torque can significantly improve the anti-loosening effect. In addition, the microscopic analyses of PTFE and MoS2 coating reveal that a reduced initial tightening torque leads to fretting wear on the thread contact surfaces of fasteners, thereby aggravating the damage. | Junbo ZHOU Jianhua LIU Huajiang OUYANG Zhenbing CAI Jinfang PENG Minhao ZHU | 2018 | Friction2018，6，1： | 10 |
| 7 | Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs显示文摘Ginkgo diterpene lactones meglumine injection(GDLI)is a commercially available product used for neuroprotection.However,the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI,i.e.,ginkgolide A(GA),ginkgolide B(GB),and ginkgolide K(GK),have never been fully evaluated in beagle dogs.In this work,a simple,sensitive,and reliable method based on ultra-fast liquid chromatography-tandem mass spectrometry(UFLC-MS/MS)was developed,and the prototypes and total amounts of GA,GB,and GK were determined in beagle dog plasma.The plasma concentrations of the hydrolyzed carboxylic forms were calculated by subtracting the prototype concentrations from the total lactone concentrations.For the first time,the pharmacokinetics of GA,GB,and GK were fully assessed in three forms,i.e.,the prototypes,the hydrolyzed carboxylic forms,and the total amounts,after intravenous administration of GDLI in beagle dogs.It was shown that ginkgolides primarily existed in the hydrolyzed form in plasma,and the ratio of hydrolysates to prototype forms of GA and GB decreased gradually to a homeostatic ratio.All of the three forms of the three ginkgolides showed linear exposure of AUC to the dosages.GA,GB,and GK showed a constant half-life approximately 2.7,3.4,and 1.2 h,respectively,which were consistent for the forms at three dose levels(0.3,1.0,and 3.0 mg·kg^(-1))and after a consecutive injection of GDLI for 7 days(1.0 mg·kg^(-1)). | WANG Shu-Yao A Ji-Ye FEI Fei GENG Jian-Liang PENG Ying OUYANG Bing-Chen WANG Pei JIN Xiao-Liang ZHAO Yu-Qing WANG Jian-Kun GENG Ting LI Yan-Jing HUA NG Wen-Zhe WANG Zhen-Zhong XIAO Wei WANG Guang-Ji | 2017 | Chinese Journal of Natural Medicines2017，15，10： | 9 |
| 8 | Ultrasonographic features of medullary thyroid carcinoma and their diagnostic values显示文摘背景髓的甲状腺癌(MTC ) 是一个稀罕恶性肿瘤并且通常困难与超声诊断。学习的目的是总结 MTC 的 sonographic 特征并且评估他们我们分析了的诊断 values.Methods 关于榴状的尺寸, echogenecity,内部内容,形状,高度 / 宽度,边阶,外部光圈,石灰化和颜色的 35 MTC 和 50 个良性的小瘤的 sonographic 特征流动模式。比率也长在在 MTC 之间的 sonographic 特征处于颈的淋巴 nodes.The 差别被估计到短轴, echogenecity,内部内容和石灰化,良性的小瘤与迟一起被分析平方测试。每个 sonographic 特征的诊断效率是主要 sonographic MTC 展示的 determined.Results 是 hypoechogenicity (包括的显著 hypoechogenicity )(n=34,97%),内部稳固的内容( n=29 ,83%),比高宽( n=34 ,97%),明确的边阶( n=24 ,69%), microcalcifications 或 macrocalcifications ( n=23 ,66%)。, echogenicity,内部内容,形状,外部光圈和石灰化在这二个组之间是显著地不同的高 / 宽,边阶,和 pednodular 和 intranodular vascularisation 不是显著地不同的。在所有单个 sonographic 特征之中,不规则的形状与 51% 的敏感和 92% 的特性有最高诊断的效率。显著 hypoechogenicity, microcalcifications,和不规则的形状的联合产出 77% 的敏感和典型 sonographic MTC 展示的 86%.Conclusions 的特性是 hypoechogenicity,主要稳固,不规则地与微石灰化的 intranodular 或宏石灰化塑造了。多重 sonographic 特征的联合有用,然而并非权威,为 MTC 的诊断。 | CAI Sheng LIU He LI Wen-bo OUYANG Yun-shu ZHANG Bo LI Peng WANG Xue-lian ZHANG Xiao-yan LI Jian-chu JIANG Yu-xin | 2010 | Chinese Medical Journal2010，，21： | 9 |
| 9 | The Effects of Different Sex-Linked Dwarf Variations on Chinese Native Chickens显示文摘Variants in chicken growth hormone receptor (GHR) gene lead to sex-linked dwarf (SLD) chickens, but effects of different variants are distinct. In this study, 11 SLD chicken breeds or strains including 3 Chinese native breeds and 8 breeding strains were studied in order to investigate the effects of different sex-linked dwarf variations on growth performance. The results showed that there were three reasons which could lead to dwarfism in the 11 breeds or strains. Firstly, an about 1.7 kb deletion of growth hormone receptor (GHR) gene leads to dwarfism in Jiangxi dwarf chicken, strains GF24, GF26, N308, N309, and N310. Secondly, a T354C mutation in exon 5 of the GHR gene leads to dwarfism in strains N301 and N305. Thirdly, an unknown variant leads to dwarfism in Guizhou Yellow Dwarf chicken and Yixing Bantam chicken. In addition, all individuals of N303 had the 1.7 kb deletion of the GHR gene, and additionally, some of them also carried the T354C mutation. As far as the performance of individuals were compared among T354C homozygote, deletion homozygote, and heterozygote carrying both T354C and deletion, it was found that the T354C's impacts on body weight of Chinese chickens were maximum, the body weight of chickens with homozygote T354C was 92.12% of those with heterozygote, and the difference of the body weight between deletion homozygote and heterozygote was not significant. There was no significant difference of shank length among three genotypes. | OUYANG Jian-hua XIE Liang NIE Qing-hua ZENG Hua PENG Zhi-jun ZHANG De-xiang ZHANG Xi-quan | 2012 | Journal of Integrative Agriculture2012，11，9： | 7 |
| 10 | System Stability and Instability: A Extended Discussion on Significance and Function of Stirring Energy Conservation Law显示文摘A discussion on significance and function of stirring energy conservation is made further. It is considered that the stirring energy conservation law is an important principle and method for analyses of stability and evolution of systems. It can be applied as both explanations of system stability and method of evolutionary analyses of a system. At the same time, some fundamental problems in the Newtonian system are pointed out. | Chen Gangyi OuYang Bolin Peng Taoyong | 2005 | 工程科学(英文版)2005，3，3： | 7 |
| 11 | A New Fire Detection Method Using a Multi-Expert System Based on Color Dispersion, Similarity and Centroid Motion in Indoor Environment显示文摘In this paper, a video fire detection method is proposed, which demonstrated good performance in indoor environment. Three main novel ideas have been introduced. Firstly, a flame color model in RGB and HIS color space is used to extract pre-detected regions instead of traditional motion differential method, as it’s more suitable for fire detection in indoor environment. Secondly, according to the flicker characteristic of the flame, similarity and two main values of centroid motion are proposed. At the same time, a simple but effective method for tracking the same regions in consecutive frames is established. Thirdly,a multi-expert system consisting of color component dispersion,similarity and centroid motion is established to identify flames.The proposed method has been tested on a very large dataset of fire videos acquired both in real indoor environment tests and from the Internet. The experimental results show that the proposed approach achieved a balance between the false positive rate and the false negative rate, and demonstrated a better performance in terms of overall accuracy and F standard with respect to other similar fire detection methods in indoor environment. | Teng Wang Leping Bu Zhikai Yang Peng Yuan Jineng Ouyang | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 7 |
| 12 | Extraction treatment of an adult patient with severe bimaxillary dentoalveolar protrusion using microscrew anchorage显示文摘Bimaxillary dentoalveolar protrusion is one of themost prevalent malocclusion in Asian population.Traditionally,orthodontic treatment often involves theextraction of four first premolars and demands the leastamount of anchorage loss,therefore headgear used to bean unavoid-able fate of these patients.Nowadays,alongwith the development of implant anchorage,more andmore patients have benefited from the implant-aidedorthodontic treatment,even escaped from orthognathicsurgery.However,for extremely severe cases,orthodontists seem to still have to face the limitation oforthodontic treatment and turn to surgeons forcooperation.In this case,we will see how dramaticchanges happened on an adult patient with severebimaxillary dentoalveolar protrusion malocclusion | OUYANG Li ZHOU Yan-heng FU Min-kui DING Peng | 2007 | Chinese Medical Journal2007，，19： | 6 |
| 13 | Hierarchical MoS2 intercalated clay hybrid nanosheets with enhanced catalytic activity显示文摘新兴的层次瞬间 2/pillared-montmorillonite (瞬间 2/PMMT) 混血儿 nanosheets 成功地在 cetyltrimethylammonium 溴化物 PMMT 的夹层以内通过瞬间 2 的灵巧的在原处热水的合成被准备,并且他们的催化表演被 4-nitrophenol (4-NP ) 的减小反应作为 reductant 用 NaBH 4 评估。微观结构和形态学描述显示瞬间 2/PMMT 与 1.29 nm,和瞬间 2 nanosheets 的夹层间距展出了叠混血儿的分层的结构在 montmorillonite (MMT ) 以内被设置层,与大多数暴露于外面的边。瞬间 2/PMMT 的催化活动和稳定性被 MMT 两个都提高。与是的瞬间 2/PMMT 催化剂, 4-NP 减小的明显的反应率常数是 0.723 min 1 并且在 ~ 被维持在五反应以后的 0.679 min 1 骑车。为 4-NP 的减小反应的瞬间 2/PMMT 和可能的催化作用机制的结构的进化被调查。同样准备的瞬间 2/PMMT 混血儿 nanosheets 在水处理和生物医学的域为催化申请正在答应候选人。在这研究开发的策略能为设计混合 nanosheets 与提供卓见多样异构二维(2D ) nanomaterials。 | Kang Peng Liangjie Fu Huaming Yang Jing Ouyang Aidong Tang | 2017 | Nano Research2017，10，2： | 6 |
| 14 | Dendrite-accelerated thermal runaway mechanisms of lithium metal pouch batteries显示文摘High-energy-density lithium metal batteries(LMBs)are widely accepted as promising next-generation energy storage systems.However,the safety features of practical LMBs are rarely explored quantitatively.Herein,the thermal runaway behaviors of a 3.26 Ah(343 Wh kg^(−1))Li|LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)pouch cell in the whole life cycle are quantitatively investigated by extended volume-accelerating rate calorimetry and differential scanning calorimetry.By thermal failure analyses on pristine cell with fresh Li metal,activated cell with once plated dendrites,and 20-cycled cell with large quantities of dendrites and dead Li,dendrite-accelerated thermal runaway mechanisms including reaction sequence and heat release contribution are reached.Suppressing dendrite growth and reducing the reactivity between Li metal anode and electrolyte at high temperature are effective strategies to enhance the safety performance of LMBs.These findings can largely enhance the understanding on the thermal runaway behaviors of Li metal pouch cells in practical working conditions. | Xiang-Qun Xu Xin-Bing Cheng Feng-Ni Jiang Shi-Jie Yang Dongsheng Ren Peng Shi HungJen Hsu Hong Yuan Jia-Qi Huang Minggao Ouyang Qiang Zhang | 2022 | SusMat2022，2，4： | 6 |
| 15 | The role of tocopherol cyclase in salt stress tolerance of rice(Oryza sativa)显示文摘Tocopherols synthesized exclusively by photosynthetic organisms are major antioxidants in biomembranes.In plants,tocopherol cyclase(TC/VTE1) catalyzes the conversion of 2,3-dimethyl-5-phytyl-1,4-benzoquinone(DMPBQ) to γ-tocopherol.In the present study,OsVTE1,which encodes a rice tocopherol cyclase ortholog,was cloned and characterized.OsVTE1 was induced significantly by abiotic stresses such as high salt,H2O2,drought,cold and by the plant hormones ABA and salicylic acid.The tissue-specific expression pattern and OsVTE1-promoter GUS activity assay showed that OsVTE1 was mainly expressed in the leaf,and also could be detected in the root,stem and panicle.Compared with control plants,transgenic plants with OsVTE1 RNA interference(OsVTE1-RNAi) were more sensitive to salt stress whereas,in contrast,transgenic plants overexpressing OsVTE1(OsVTE1-OX) showed higher tolerance to salt stress.The DAB in vivo staining showed that OsVTE1-OX plants accumulated less H2O2 than did control plants. | OUYANG ShouQiang HE SiJie LIU Peng ZHANG WanKe ZHANG JinSong CHEN ShouYi | 2011 | Science China(Life Sciences)2011，54，2： | 6 |
| 16 | Potential therapeutic options for coronavirus disease 2019:using knowledge of past outbreaks to guide future treatment显示文摘In December 2019,initial cases of the novel coronavirus(2019-nCoV)infection,termed coronavirus disease 2019(COVID-19),were first reported in Wuhan,China.[1]In humans,infections with the human coronavirus 229E,OC43,NL63,and HKU1 usually result in mild,selflimiting upper respiratory tract infections.However,other variants have rapid transmission rates and can cause severe respiratory syndrome and death.These variants include severe acute respiratory syndrome coronavirus(SARSCoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and the current 2019-nCoV. | John Lin Jing Ouyang Xiao-Rong Peng Stephane Isnard Brandon Fombuena Jean-Pierre Routy Yao-Kai Chen | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 17 | Progress review of US-China joint research on advanced technologies for plug-in electric vehicles显示文摘The United States and China are the world's largest automobile markets and oil consumers, and both face a severe challenge to conserve energy and reduce tailpipe emissions. Thus, both countries urgently need to transform conventional internal combustion engines to electrified powertrains. Targeting the advanced core technologies of plug-in electric vehicles(PEVs), a joint research collaboration between China and the US, called the 'Clean Vehicle Consortium'(CVC), was set up in 2010. Six years of collaboration on PEV technologies has resulted in significant progress in three technical areas. Based on CVC publications,we review herein the progress made by the CVC research efforts on three key advanced PEV technologies. This includes the development of a safe battery with an energy density of 260 W h kg^(-1) and a systematic method for designing safe traction battery systems. Thus, a breakthrough in high power density and efficient traction motor systems has occurred. In addition to discussing advanced electric-drive powertrains, we also discuss global energy management strategies that aim to improve PEV energy efficiency. This discussion covers scientific and comprehensive analysis methods to analyze energy systems, which include costbenefit analyses of plug-in hybrid electric vehicles, life-cycle assessments for evaluating vehicle emissions, and PEV-ownership projections. | OUYANG MingGao DU JiuYu PENG Huei WANG HeWu FENG XuNing SONG ZiYou | 2018 | Science China(Technological Sciences)2018，61，10： | 5 |
| 18 | The pulsed high magnetic field facility and scientific research at Wuhan National High Magnetic Field Center显示文摘Wuhan National High Magnetic Field Center(WHMFC)at Huazhong University of Science and Technology is one of the top-class research centers in the world,which can offer pulsed fields up to 90.6 T with different field waveforms for scientific research and has passed the final evaluation of the Chinese government in 2014.This paper will give a brief introduction of the facility and the development status of pulsed magnetic fields research at WHMFC.In addition,it will describe the application development of pulsed magnetic fields in both scientific and industrial research. | Xiaotao Han Tao Peng Hongfa Ding Tonghai Ding Zengwei Zhu Zhengcai Xia Junfeng Wang Junbo Han Zhongwen Ouyang Zhenxing Wang Yibo Han Houxiu Xiao Quanliang Cao Yiliang Lv Yuan Pan Liang Li | 2017 | Matter and Radiation at Extremes2017，2，6： | 5 |
| 19 | Structural information aware deep semi-supervised recurrent neural network for sentiment analysis显示文摘 | Wenge RONG Baolin PENG Yuanxin OUYANG Chao LI Zhang XIONG | 2015 | Frontiers of Computer Science2015，9，2： | 5 |
| 20 | Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons显示文摘Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.However,the pathogenesis underlying long-term adenosine A1 receptor activation-induced neurodegeneration remains unclear.In this study,rats were intraperitoneally injected with 5 mg/kg of the adenosine A1 receptor agonist N6-cyclopentyladenosine(CPA)for five weeks.The mobility of rats was evaluated by forced swimming test,while their cognitive capabilities were evaluated by Y-maze test.Expression of sortilin,α-synuclein,p-JUN,and c-JUN proteins in the substantia nigra were detected by western blot analysis.In addition,immunofluorescence staining of sortilin andα-synuclein was performed to detect expression in the substantia nigra.The results showed that,compared with adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine(5 mg/kg)+CPA co-treated rats,motor and memory abilities were reduced,surface expression of sortin andα-synuclein in dopaminergic neurons was reduced,and total sortilin and totalα-synuclein were increased in CPA-treated rats.MN9D cells were incubated with 500 nM CPA alone or in combination with 10μM SP600125(JNK inhibitor)for 48 hours.Quantitative real-time polymerase chain reaction analysis of sortilin andα-synuclein mRNA levels in MN9D cells revealed upregulated sortilin expression in MN9D cells cultured with CPA alone,but the combination of CPA and SP600125 could inhibit this expression.Predictions made using Jasper,PROMO,and Alibaba online databases identified a highly conserved sequence in the sortilin promoter that was predicted to bind JUN in both humans and rodents.A luciferase reporter assay of sortilin promoter plasmid-transfected HEK293T cells confirmed this prediction.After sortilin expression was inhibited by sh-SORT1,expression of p-JUN and c-JUN was detected by western blot analysis.Long-term adenosine A1 receptor activation levels upregulatedα-synuclein expression at the post-transcriptional level by affecting sortilin expression.The online tool Raptor-X-Binding and Discovery Studio 4.5 prediction software predicted that sortilin can bind toα-synuclein.Co-immunoprecipitation revealed an interaction between sortilin andα-synuclein in MN9D cells.Our findings indicate that suppression of prolonged adenosine A1 receptor activation potently inhibited sortilin expression andα-synuclein accumulation,and dramatically improved host cognition and kineticism.This study was approved by the University Committee of Animal Care and Supply at the University of Saskatchewan(approval No.AUP#20070090)in March 2007 and the Animals Ethics Committee of University of South China(approval No.LL0387-USC)in June 2017. | Yun-Cheng Lv An-Bo Gao Jing Yang Li-Yuan Zhong Bo Jia Shu-Hui Ouyang Le Gui Tian-Hong Peng Sha Sun Francisco S.Cayabyab | 2020 | Neural Regeneration Research2020，15，4： | 4 |
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