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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Cyst of the choroidplexus in the lateral ventrlce, case report and review of the Literature 显示文摘 | Odake G Tenjin H Murakaml N | 1990 | Neurosurgery1990，27，3： | 1 |
| 3 | Acute fractures of the scaphoid bone: Systematic review and meta-analysis显示文摘 | ALSHRYDA S SHAH A ODAK S | 2012 | Surgeon2012，10，4： | 1 |
| 4 | Cystic meningioma:report of three patients显示文摘 | Odake G | 1992 | Neurosurgery1992，30，6： | 1 |
| 5 | Cysts meningioma:Repont of three patients显示文摘 | Odake G | 1992 | Neurosurgery1992，30，6： | 1 |
| 6 | Cystic meningioma:report of three patients显示文摘 | Odake G | 1992 | Neurosurgery1992，30，6： | 1 |
| 7 | Chemical structures of two anthocyanins from purple sweet potato, Ipomoea Bata- tas 显示文摘 | Odake K Terahqra N Saito N | 1992 | Phytochem1992，31，6： | 1 |
| 8 | Integration of an immunosorbent assay system:analysis of secretory human immunoglobulin A on polystyrene beads in a microchip显示文摘 | Sato K Tokeshi M Odake T | 2000 | Anal Chem2000，72，6： | 1 |
| 9 | p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphory- latedp53显示文摘 | OdaK Arakawa H Tanaka T | 2000 | Cell2000，102，6： | 1 |
| 10 | Chemical structures of two anthocyanins from purple sweet potato,Ipomoea batatas显示文摘 | Odake K Terahara N Saito N | 1992 | Phytochemistry1992，31，6： | 1 |
| 11 | Eudesmane derivatives from Tessaria integrifolia 显示文摘 | Ono M Masuoka C Odake Y | 2000 | Phytochemistry2000，53，4： | 1 |
| 12 | To what degree is digital imaging reliable? Validation of femoral neck shaft angle measurement in the era of picture archiving and communication systems 显示文摘 | Wilson JD Eardley W Odak S | 2011 | Br J Radiol2011，84，1000： | 1 |
| 13 | A high-efficiency cross-flow micronebulizer for inductively coupled plasma mass spectrometry显示文摘 | LI Jin-xiang UMEMURA T ODAKE T | | 0，，07： | 1 |
| 14 | Epidermal changes caused by chronic low-dose UV irradiation induce wrinkle formation in hairless mouse显示文摘 | Kambayashi H Yamashita M Odake Y | 2001 | Journal of DermatologicalScienee2001，27，1： | 1 |
| 15 | Cystic meningioma: report of three patients显示文摘 | Odake G | 1992 | Neurosurgery1992，31，： | 1 |
| 16 | Pulsed laser processing of nano-polycrystalline diamond显示文摘 | Odake S Ohfuji H Okuchi T | 2008 | Diamond and Related Materials2008，10，： | 1 |
| 17 | Intracranial hypoglossal neurinoma with extrac- ranial extension: review and case report 显示文摘 | Odake G | 1989 | Neurosurgery1989，24，4： | 1 |
| 18 | Chemical structures of two anthocyanins from purple sweet potato, Ipomoea Batatas显示文摘 | Kinnosuke Odake Norihiko Terahara Norio Saito Kenjiro Toki and Toshio Honda | 1992 | Phytochemistry1992，31，6： | 1 |
| 19 | Chemical structures of two anthocyanins from purple sweet potato, Ipomoea batatas显示文摘 | ODAKE K TERAHARA N SAITO N | 1992 | Phytochemistry1992，31，6： | 1 |
| 20 | Epidermal changes caused by chronic low- dose UV irradiation induce wrinkle formation in hairless mouse 显示文摘 | Kambayashi H Yamashita M Odake Y | 2000 | J Dermatol Sci2000，27，1： | 1 |
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