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| 1 | Endorectal ultrasonography versus phased-array magnetic resonance imaging for preoperative staging of rectal cancer显示文摘AIM: To compare the diagnostic accuracy of pelvic phased-array magnetic resonance imaging (MRI) and endorectal ultrasonography (ERUS) in the preoperative staging of rectal carcinoma. METHODS: Thirty-four patients (15 males, 19 females) with ages ranging between 29 and 75 who have biopsy proven rectal tumor underwent both MRI and ERUS examinations before surgery. All patients were evaluated to determine the diagnostic accuracy of depth of transmural tumor invasion and lymph node metastases. Imaging results were correlated with histopathological findings regarded as the gold standard and both modalities were compared in terms of predicting preoperative local staging of rectal carcinoma. RESULTS: The pathological T stage of the tumors was: pT1 in 1 patient, pT2 in 9 patients, pT3 in 21 patients and pT4 in 3 patients. The pathological N stage of the tumors was: pN0 in 19 patients, pN1 in 9 patients and pN2 in 6 patients. The accuracy of T staging for MRI was 89.70% (27 out of 34). The sensitivity was 79.41% and the specificity was 93.14%. The accuracy of T staging for ERUS was 85.29% (24 out of 34). The sensitivity was 70.59% and the specificity was 90.20%. Detection of lymph node metastases usingphased-array MRI gave an accuracy of 74.50% (21 out of 34). The sensitivity and specificity was found to be 61.76% and 80.88%, respectively. By using ERUS in the detection of lymph node metastases, an accuracy of 76.47% (18 out of 34) was obtained. The sensitivity and specificity were found to be 52.94% and 84.31%, respectively. CONCLUSION: ERUS and phased-array MRI are complementary methods in the accurate preoperative staging of rectal cancer. In conclusion, we can state that phased-array MRI was observed to be slightly superior in determining the depth of transmural invasion (T stage) and has same value in detecting lymph node metastases (N stage) as compared to ERUS. | Ahmet Mesrur Halefoglu Sadik Yildirim Omer Avlanmis Damlanur Sakiz Adil Baykan | 2008 | World Journal of Gastroenterology2008，14，22： | 35 |
| 2 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 3 | Risk factors for fever and sepsis after percutaneous nephrolithotomy显示文摘Objective:Percutaneous nephrolithotomy(PCNL)is commonly used in the management of large renal stones.Postoperative infections are one of the most common complications of this procedure.The present study is to determine and assess the factors that may increase the risk to develop fever and urinary sepsis after PCNL.Methods:A total of 60 patients(38 males and 22 females)with a mean age of 40.25 years enrolled in this study in Sulaimania Teaching Hospital.Patients had renal stone disease need operation with different socioeconomic status,body mass index and different type and size of stones were included in this study.Patients with preoperative positive urine culture and sensitivity were excluded.Preoperative investigations done for all patients.All Patients received prophylactic antibiotic gentamicin intravenously at the induction of anaesthesia.Renal pelvis urine sample were taken from all patients after puncturing the pelvicalyceal system and send for culture and sensitivity.Patients were monitored closely in the postoperative period for the development of fever and sepsis.Results:Mean duration of the operations was 77.08 min ranged 40e120 min.All patients had postoperative nephrostomy tube.Seventeen(28.33%)patients developed post PCNL fever and the statistically significant factors for post PCNL fever were diabetes mellitus(DM)(p Z 0.001),stone burden(p Z 0.001),number of the stones(p<0.001),degree of hydronephrosis(p Z 0.001),duration of the operation(p<0.001),residual stones(p Z 0.001)and number of tracts(p Z 0.038).Three(5.00%)patients developed post PCNL sepsis,and the statistically significant risk factors for post PCNL sepsis were duration of the operation(p Z 0.013)and intraoperative blood loss,postoperative drop in haemoglobin(HB)level(p Z 0.046).Conclusion:DM,staghorn stones,degree of hydronephrosis,duration of the operation and number of tracts are risk factors for post PCNL fever,while number of stones,intraoperative blood loss,duration of the operation and residual stones are risk factors for post PCNL sepsis. | Aso Omer Rashid Saman Salih Fakhulddin | 2016 | Asian Journal of Urology2016，3，2： | 21 |
| 4 | Radical vs conservative surgery for hydatid liver cysts:Experience from single center显示文摘AIM:To compare the efficacy and safety of radical and conservative surgical interventions for liver hydatid disease.METHODS:The study comprised 59 patients in two groups who had undergone radical and conservative surgical procedures for liver hydatid disease in our department between 2004 and 2009. Preoperative diagnostic tools,medical treatments,demographic and clinical characteristics,postoperative follow-up,and recurrence were compared in both groups. RESULTS:This non-randomized retrospective studyincluded 59 patients who had undergone liver hydatid disease surgery. The radical technique was used in 18 patients (mean age:42.1 ± 13.5 years,seven male,11 female),and the conservative technique was used in 41 patients (mean age:43.5 ± 13.9 years,17 male,24 female). The follow-up period ranged from 3 to 58 mo. Although operative time was significantly shorter in the conservative group (P < 0.001),recurrence was significantly reduced in the radical group (P = 0.045). No statistically significant differences were found in terms of hospitalization duration,cyst count and size,location,postoperative complications,scolicidal solution usage,or follow-up duration between the two groups.CONCLUSION:The more effective method for pre-venting postoperative recurrence is radical surgery. En-doscopic retrograde cholangiopancreatography for bile leakage in the early postoperative period may decrease the requirement for repeat surgery. | Sami Akbulut Ayhan Senol Arsenal Sezgin Bahri Cakabay Mehmet Dursun Omer Satici | 2010 | World Journal of Gastroenterology2010，16，8： | 19 |
| 5 | Outcomes of partial splenic embolization in patients with massive splenomegaly due to idiopathic portal hypertension显示文摘AIM To determine the outcomes of partial splenic em-bolization(PSE) for massive splenomegaly due to idiopathic portal hypertension(IPH).METHODS In this prospective study, we evaluated the charac-teristics and prognosis of consecutive patients with IPH who underwent PSE for all indications at a single medical center between June 2009 and January 2015. The inclusion criteria were: presence of hypersplenism, massive splenomegaly, and resultant pancytopenia. The exclusion criteria were: presence of other diseases causing portal hypertension. During the post-PSE period, the patients were hospitalized. All patients underwent abdominal computed tomography imaging 4 wk post-PSE to determine total splenic and non-infarcted splenic volumes.RESULTS A total of 11 patients, with median age of 33.27 ± 4.8 years, were included in the study. Mean spleen size was 22.9 cm(21-28 cm), and severe hypersplenismwas diagnosed in all patients before PSE. Post-PSE, leukocyte and platelet counts increased significantly, reaching peak levels in the second week with gradual decreases thereafter. Liver function tests did not exhibit significant changes during post-intervention follow-up. All patients developed post-embolization syndrome, and one patient experienced serious complications; all complications were successfully treated with conservative therapy and no death occurred. CONCLUSION Our findings showed that PSE has a lower complication rate than previously-reported surgical complication rates, which supports this intervention as a viable alternative for high-risk operable patients with severe hypersplenism. | Omer Ozturk Gonca Eldem Bora Peynircioglu Taylan Kav Aysegul Gormez Barbaros Erhan Cil Ferhun Balkanci Cenk Sokmensuer Yusuf Bayraktar | 2016 | World Journal of Gastroenterology2016，22，43： | 18 |
| 6 | Circulating microRNAs in patients with non-alcoholic fatty liver disease显示文摘AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease(NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The rela-tive expressions of miR-197, miR-146 b, miR-10 b, miR-181d, miR-34 a, miR-122, miR-99 a and miR-29 a were analyzed using real-time polymerase chain reaction. RESULTS: Serum levels of miR-181 d, miR-99 a, miR-197 and miR-146 b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum lev-els of miR-197 and miR-10 b were inversely correlated with degree of inflammation and miR-181 d and miR-99 a were inversely correlated with serum gamma glu-tamyl transferase levels in non-alcoholic steatohepatitis patients. CONCLUSION: NAFLD is associated with altered se-rum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD. | Serkan Dogan Gokmen Zararsiz Sebnem Gursoy Kadri Guven Omer Ozbakir Munis Dundar Mehmet Yucesoy | 2014 | World Journal of Hepatology2014，6，8： | 13 |
| 7 | Rare etiology of mechanical intestinal obstruction: Abdominal cocoon syndrome显示文摘Abdominal cocoon syndrome is a rare cause of intestinal obstruction with unknown etiology. Diagnosis of this syndrome, which can be summarized as the small intestine being surrounded by a fibrous capsule not containing the mesothelium, is difficult in the preoperative period. A 47-year-old male patient was referred to the emergency department with complaints of abdominal pain, nausea, and vomiting for two days. The abdominal computed tomography examination detected dilated small intestinal loops containing air-fluid levels clustered in the left upper quadrant of the abdomen and surrounded by a thick, saclike, contrast-enhanced membrane. During exploratory surgery, a capsular structure was identified in the upper left quadrant with a regular surface that was solid-fibrous in nature. Ab-dominal cocoon syndrome is a rarely seen condition, for which the preoperative diagnosis is difficult. The combination of physical examination and radiological signs, and the knowledge of 'recurrent characteristics of the complaints' that can be learned by a careful history, may be helpful in diagnosis. | Yener Uzunoglu Fatih Altintoprak Omer Yalkin Yasemin Gunduz Guner Cakmak Orhan V Ozkan Fehmi Celebi | 2014 | World Journal of Clinical Cases2014，2，11： | 13 |
| 8 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 9 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 10 | 帕罗西汀与达帕西汀的对比,治疗早泄的新的选择性5-羟色胺再摄取抑制剂显示文摘达帕西汀氢氯化物是一种选择性5-羟色胺再摄取抑制剂,也是第一种被批准可以按需服用治疗早泄的药物。本文目的为研究按需服用达帕西汀(30mg和H60mg)和每日服用帕罗西汀(20mg)对早泄的疗效。研究募集了150名患者进行了长达1个月的研究。患者被分成3组,每组50人。第一组按需服用达帕西汀30mg。第二组按需服用达帕西汀60mg。第三组每日服用帕罗西汀20mg。治疗结束后,我们的结果检测值相对于基准阴道内射精潜伏期(IELT)延长了。与基准IELT相比,帕罗西汀组、30mg达帕西汀组和60mg达帕西汀组的治疗后IELT分别延长了117%(P〈0.01),117%(P〈0.01)和170%(P〈0.01)。30mg达帕西汀组和帕罗西汀组的IELT增幅相同(P〉0.05),而60mg达帕西汀组的IELT增幅明显高于30mg达帕西汀组(P〈0.05和帕罗西汀组P〈0.01)。性交前1~3小时服用达帕西汀60mg是针对早泄的非常有效的治疗方法。然而,与当前普遍使用的帕罗西汀相比,达帕西汀30mg疗效并不显著。 | Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz | 2014 | Asian Journal of Andrology2014，16，5： | 10 |
| 11 | Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats显示文摘AIM: To investigate the effects of Nigella sativa L (NS)and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl4-treated rats.METHODS: Fifty-six healthy male Wistar albino rats were used in this study. The rats were randomly allotted into one of the four experimental groups: A (CCl4-only treated), B (CCl4+UD treated), C (CCl4+NS treated) and D (CCl4+UD+NS treated), each containing 14 animals.All groups received CCl4 (0.8 mL/kg of body weight, sc,twice a week for 60 d). Tn addition, B, C and D groups also received daily J.p. injections of 0.2 mL/kg NS or/and 2 mL/kg UD oils for 60 d. Group A, on the other hand,received only 2 mL/kg normal saline solution for 60 d.Blood samples for the biochemical analysis were taken by cardiac puncture from randomly chosen-seven rats in each treatment group at beginning and on the 60th d of the experiment.RESULTS: The CCl4 treatment for 60 d increased thelipid peroxidation and liver enzymes,and also decreasedthe antioxidant enzyme levels. NS or UD treatment (aloneor combination) for 60 d decreased the elevated lipidperoxidation and liver enzyme levels and also increasedthe reduced antioxidant enzyme levels.The weight ofrats decreased in group A,and increased in groups B, Cand D.CONCLUSION: NS and UD decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defense system activity in the CCl4-treated rats. | Mehmet Kanter Omer Coskun Mustafa Budancamanak | 2005 | World Journal of Gastroenterology2005，11，42： | 9 |
| 12 | Glasgow coma scale and APACHE-II scores affect the liver transplantation outcomes in patients with acute liver failure显示文摘BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P<0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation. | Necdet Guler Omer Unalp Ayse Guler Onur Yaprak Murat Dayangac Murat Sozbilen Murat Akyildiz Yaman Tokat | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 9 |
| 13 | 向日葵花盘功能成分及研究现状显示文摘向日葵(Helianthus annuus L.)作为我国重要的油料作物之一,其葵花籽油的提取已经实现工业化生产,但其副产物向日葵盘、秸秆、葵花籽壳和饼粕等仍然利用不足。随着技术设备条件的优化及产业化条件的成熟,向日葵副产物具有十分广阔的开发应用前景。本文对向日葵花盘现阶段的综合利用情况进行介绍,并总结了向日葵花盘中绿原酸、水溶性多糖、萜类化合物等重要活性物质的提取方法。针对我国目前面临的向日葵作物综合利用发展中出现的向日葵花盘副产物处理难问题,阐述了向日葵花盘的药用价值及其重新开发和综合利用的方法,为向日葵花盘的利用提供指导。 | 赵萍 Saeed Hamid Saeed Omer 杨恒 刘金涛 张子亮 刘裕慧 王欢 魏明广 | 2018 | 生物资源2018，40，3： | 9 |
| 14 | H pylori:Treatment for the patient only or the whole family?显示文摘AIM:To compare the effects of treatment of H pylori-infected individuals with the effects of treatment of individuals as well as all H pylori-infected family members. METHODS:H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all H pylori-positive family members living together (groupⅠ) or patients only (group Ⅱ). Nine months after treatment, all patients were assessed for H pylori positivity. RESULTS:There were 70 H pylori-positive patients in each group;patients in groupsⅠand Ⅱ lived with 175 and 190 H pylori-positive relatives, respectively. Age, sex and H pylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, H pylori positivity was 7.1% in groupⅠpatients and 38.6% in group Ⅱ patients [P < 0.01, OR = 8.61 95% confidence interval (CI):2.91-22.84]. CONCLUSION:The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pylori-positive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high;they also suggest patients, their spouses and all H pylori-positive family members of H pylori-positive individuals should be treated for H pylori infection. | Yavuz Selim Sari Didem Can Vahit Tunali Orhan Sahin Oguz Koc Omer Bender | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 15 | Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis显示文摘AIM:To investigate in vitro effects of propofol,midazolam and dexmedetomidine,which are commonly used anaesthesic or sedatives,on spontaneous contractions of the ileum both in normal rats and those exposed to hyperdynamic peritonitis.METHODS:Spontaneous contractions of isolated ileum muscle segments from sham operated rats and those exposed to peritonitis,were studied in vitro.The amplitude and the frequency of spontaneous contractions of ileum muscle segments were studied after adding dexmetetomidine,propofol,and midazolam to the organ bath in a cumulative manner.RESULTS:Both amplitude(85.2±6.6 vs 47.4±7.1)and frequency(32.8±4.6 vs 20.2±3.9)of spontaneous contractions in ileum smooth muscle segments were decreased significantly in the peritonitis group compared to the control group(P<0.05).Dexmedetomidine significantly increased the amplitude of spontaneous contractions(85.2±6.6 vs 152.0±5.4,P<0.05)whereas,propofol(85.2±6.6 vs 49.6±4.8,P<0.05)and midazolam(85.2±6.6 vs 39.2±4.5,P<0.05)decreased it in both control and peritonitis groups.The frequency of spontaneous contractions were significantly decreased by propofol in both control(32.8±4.6 vs 18.2±3.4,P<0.05)and peritonitis groups 20.2±3.9 vs 11.6±3.2,P<0.05).Dexmedetomidine and midazolam did not cause significant changes in the number of spontaneous contractions in both control and the peritonitis groups(P>0.05).CONCLUSION:Propofol,midazolam and dexmedetomidine have various in vitro effects on spontaneous contractions of the rat ileum.While dexmedetomidine augments the spontaneous contraction of the rat ileum,propofol attenuates it.However,the effects of these compounds were parallel in both control and peritonitis groups. | Cengiz Aydin Ihsan Bagcivan Sinan Gursoy Ahmet Altun Omer Topcu Ayhan Koyuncu | 2009 | World Journal of Gastroenterology2009，15，13： | 6 |
| 16 | Confounders of uric acid level for assessing cardiovascular outcomes显示文摘We read the article entitled Serum uric acid as a prognostic marker in the setting of advanced vascular disease:a prospective study in the elderly by Stolfo,et al.[1] with great interest.The authors evaluated the association of serum uric acid (SUA) levels with adverse cardiovascular events and deaths in an elderly population affected by advanced atherosclerosis.They founded meaningful association between SUA levels and of cardiovascular events and cancer related death.We believe that these findings will lead for further studies on uric acid. | Mehmet Dogan Omer Uz Mustafa Aparci Murat Atalay | 2016 | Journal of Geriatric Cardiology2016，13，2： | 6 |
| 17 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 18 | 缺血性间歇性阴茎异常勃起的药物治疗:当前的文献综述显示文摘阴茎异常勃起是指阴茎在没有受性刺激的情况下,发生的不自主的长时间勃起。目前,关于这种异常勃起的病理生理学信息很少,所以我们对此疾病也知之甚少。这种不可逆的勃起伤害以及导致的勃起功能障碍使这种疾病的并发症也很可怕。间歇性阴茎异常勃起尽管很少见,但在镰状细胞疾病(SCD)患者中发生率很高,而且也迫切需要制定指南来治疗这些病人的勃起功能问题。因为对这种疾病的发病机制不是很清楚,所以对泌尿外科医生来说,这种疾病的药物治疗也是一个极大的挑战。还需要更多的研究让我们可以有效确定这些病人的治疗方法,以预防作为最终目的。本综述主要介绍间歇性阴茎异常勃起疾病及其临床意义,尤其针对那些有SCD的病人。另外,还讨论该疾病可能的病理生理学机制,总结和讨论当前和将来的药物治疗策略。 | Helen R Levey Omer Kutlu Trinity J Bivalacqua | 2012 | Asian Journal of Andrology2012，14，1： | 5 |
| 19 | Effect of Valence Band Tail Width on the Open Circuit Voltage of P3HT:PCBM Bulk Heterojunction Solar Cell:AMPS-1D Simulation Study显示文摘P3HT 的开的电路电压上的原子价乐队尾巴宽度的效果: PCBM 体积异质接面太阳能电池被使用 AMPS-1D 计算机程序调查。有指数的原子价和传导乐队尾巴状态的一个有效中等模型被用来模仿光电的房间。模拟结果证明开的电路电压线性地取决于产生率的对数,斜坡取决于原子价乐队尾巴的宽度。开的电路电压与乐队尾巴的增加的宽度减少。黑暗、轻的想象力因素与原子价乐队尾巴的宽度增加。 | Bushra Mohamed Omer | 2015 | Chinese Physics Letters2015，32，8： | 5 |
| 20 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
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