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| 1 | 北京市郊区儿童维生素D营养状况与骨量的关系显示文摘目的了解北京市怀柔区儿童维生素D营养状况与骨量的关系,为改善我国儿童骨骼健康提供基础资料。方法采用横断面研究的方法 ,随机选取北京市怀柔区(北纬40.3°)381名7-11岁儿童,采集静脉血,用酶联免疫吸附法测定血清25-羟维生素D[25(OH)D]浓度,双能X线吸收仪测定前臂及全身骨矿物含量(BMC)、骨矿物密度(BMD)和骨面积(BA)。结果研究对象血清25(OH)D浓度平均为(44.4±12.5)nmol/L。血清25(OH)D浓度与身高、体重及全身和前臂的BMC、BMD和BA呈显著正相关(r=0.10~0.17;P〈0.05);调整年龄、性别、身高和体重后,仅全身分部位中的左上肢BMC和左上肢及右上肢BA与血清25(OH)D浓度呈正相关(r=0.11-0.14;P〈0.05),其余部位显著性消失。维生素D营养状况适宜儿童[25(OH)D〉50 nmol/L]的全身BMC比维生素D不足儿童[25(OH)D≤50 nmol/L]平均高4.2%(P〈0.05),但调整混杂因素后差异消失。结论维生素D营养状况与北京郊区儿童体格发育正相关,从而对儿童骨量增加起到间接促进作用。 | 张倩 赵静 张环美 郭宏霞 Rickard Oste 郝利楠 Gunilla Onning Lena Hulthén 胡小琪 | 2010 | 中国预防医学杂志2010，11，8： | 25 |
| 2 | 欧洲肿瘤内科协会对非上皮性卵巢癌的诊断、治疗和随访所制定的临床实践指南显示文摘非上皮性卵巢癌是一类少见的卵巢癌,因此,其诊断较难建立。然而,通过仔细观察各种肿瘤的标记物[尤其是人绒毛膜促性腺激素β亚单位(β-hCG)、α-甲胎蛋白(α-AFP)和乳酸脱氢酶(LDH)]、临床体征(如妊娠期体征, | Reed N Millan D Verheijen R Castiglione M On behalf of the ESMO Guidelines Working Group 杨华(译) 郎景和(审校) | 2011 | 国际妇产科学杂志2011，38，4： | 13 |
| 3 | Thrombin activation and liver inflammation in advanced hepatitis C virus infection显示文摘Hepatitis C virus(HCV) infection is associated with increased thrombotic risk. Several mechanisms are involved including direct endothelial damage by the HCV virus, with activation of tissue factor, altered fibrinolysis and increased platelet aggregation and activation. In advanced stages, chronic HCV infection may evolve to liver cirrhosis, a condition in which alterations in the portal microcirculation may also ultimately lead to thrombin activation, platelet aggregation, and clot formation. Therefore in advanced HCV liver disease there is an increased prevalence of thrombotic phenomena in portal vein radicles. Increased thrombin formation may activate hepatic stellate cells and promote liver fibrosis. In addition, ischemic changes derived from vascular occlusion by microthrombi favor the so called parenchymal extinction, a process that promotes collapse of hepatocytes and the formation of gross fibrous tracts. These reasons may explain why advanced HCV infection may evolve more rapidly to end-stage liver disease than other forms of cirrhosis. | Emilio González-Reimers Geraldine Quintero-Platt Candelaria Martín-González Onán Pérez-Hernández Lucía Romero-Acevedo Francisco Santolaria-Fernández | 2016 | World Journal of Gastroenterology2016，22，18： | 5 |
| 4 | Liver steatosis in hepatitis C patients显示文摘There is controversy regarding some aspects of hepatitis C virus(HCV) infection-associated liver steatosis,and their relationship with body fat stores. It has classically been found that HCV,especially genotype 3,exerts direct metabolic effects which lead to liver steatosis. This supports the existence of a so called viral steatosis and a metabolic steatosis,whichwould affect HCV patients who are also obese or diabetics. In fact,several genotypes exert metabolic effects which overlap with some of those observed in the metabolic syndrome. In this review we will analyse the pathogenic pathways involved in the development of steatosis in HCV patients. Several cytokines and adipokines also become activated and are involved in 'pure' steatosic effects,in addition to inflammation. They are probably responsible for the evolution of simple steatosis to steatohepatitis,making it difficult to explain why such alterations only affect a proportion of steatosic patients. | Emilio González-Reimers Geraldine Quintero-Platt Melchor Rodríguez-Gaspar Remedios Alemán-Valls Onán Pérez-Hernández Francisco Santolaria-Fernández | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 5 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 6 | VI,Influence of phosphorus nutrition on geowth and flavonoid content显示文摘 | Murali N S Teramura A H Effects of UV- B radiation on the soybean | 1985 | Physiol Plant1985，63，： | 2 |
| 7 | Rapid PCRbased identification of apple(Malus)cultivars and species显示文摘 | Mort on A Adams A N Barbara D J | 1993 | BCPC Monograph1993，54，： | 1 |
| 8 | Quantitative relationship between phenyllanine ammonialyase leve and phenylpropanoid accumulation intransgenic tobacco identifies a ratedetermining step in natural product synthesis显示文摘 | Bate N J On J Ni W | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 9 | he ecophysiologi , Pinus densiflo t, 2003,176:195 Effects of uncal characteris- ra 显示文摘 | Kume A~ derstory vegetation on t tics of an overstory pine Ecology and Managemen Tsubei N | 2003 | Forest2003，203，： | 1 |
| 10 | The EURODIALE Study 显示文摘 | Prompers L Schaper N Apelqvist J Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease | 2008 | Diabetologia2008，51，5： | 1 |
| 11 | Untreated growing cranial fractures detected in late stage显示文摘 | Kutlay M Demircan N Akin ON | 1998 | Neurosurgery1998，43，： | 1 |
| 12 | Suppressed endothelin-1 production by FK506 and cyclosporin A in ischemia/reperfusion of rat small intestine 显示文摘 | el-Assal ON Yu L Nagasue N | 1999 | Surgery1999，125，1： | 1 |
| 13 | Scientific Opinion on the essential composition of infant and follow-on formulae 显示文摘 | EFSA NDA PANEL (EFSA PANEL ON DIETETIC PRODUCTS N A A | 2014 | EFSAJoumal2014，12，7： | 1 |
| 14 | composite shrinkage strain kinetics,temperature rise,and hardness 显示文摘 | Hofmann N Hugo B Klaiber BZffect of irradiation type(LED or QTH)on photoactivated | 2002 | Eur J Oral Sci2002，110，6： | 1 |
| 15 | Protecting the retinal pigment epithelium during macular hole surgery 显示文摘 | Olson J L On A V Mandava N | 2005 | Clin Experiment Ophthalmol2005，33，： | 1 |
| 16 | Catalytic epoxidation of α-pinene over bifunctional mesoporous molecular sieves 显示文摘 | On D T Kapoor M P Joshi P N | 1997 | CatalLett1997，44，34： | 1 |
| 17 | Pranlukast, anovel leukotriene receptor antagonist: results of the first European, placebo controlled, multicentre clinical study in asthma显示文摘 | Pujer J - C on behalf of an international study group | 1997 | Thorax1997，52，： | 1 |
| 18 | Ultrasono- graphic quantitative estimation of hepatic steatosis in children with NAFLD显示文摘 | Shann on A Alkhouri N Carte r-Kent C | 2011 | J Pediatr Gastroenterol Nutr2011，53，2： | 1 |
| 19 | Heme oxygenase-1 medi- ates oxidative stress and apoptosis in coxsaekievirus B3-induced myocarditis显示文摘 | Ursu ON Sauter M Ettischer N | 2014 | Cell Physiol Biochem2014，33，1： | 1 |
| 20 | The small for size liver syndrome显示文摘 | Tucker ON Heaton N | 2005 | Curt Opin Crit Care2005，11，2： | 1 |
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