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| 1 | Plasma and platelet serotonin levels in patients with liver cirrhosis显示文摘AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P < 0.0001). The mean platelet serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P < 0.05). However, platelet serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content. | ■or■e M ulafi Duko S Mirkovi Miodrag D Vukevi Jelena S Rudi | 2007 | World Journal of Gastroenterology2007，13，43： | 5 |
| 2 | Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial 显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncoi2009，10，1： | 1 |
| 3 | Survival after laparoscopic surgery versus open surgery for colon cancer: long- term outcome of a randomised clinical trial 显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R Hop WC | 2009 | Lancet Oncol2009，10，： | 1 |
| 4 | Lack of relationship between leukoaraiosis and carotid artery disease显示文摘 | Streifler JY Eliasziw M Benavente OR | 1995 | Arch Neurol1995，52，1： | 1 |
| 5 | NAFLD as a risk factor for the development of diabetes and the metabolic syndrome:An eleven year follow-up study显示文摘 | ADAMS LA WATERS OR KNUIMAN M | 2007 | Hepatology2007，46，4： | 1 |
| 6 | Discovery o{ a gene conferring multiple-aminoglycoside resistance in Escherichia coli 显示文摘 | Davis M A Baker K N Or{e L H | 2010 | Antimicrobial Agents and Ahemotherapy2010，54，6： | 1 |
| 7 | Problematic clinical isolates of Pseudomonas aeruginosa from the university hospitals in Sofia,Bulgaria: current status of antimicrobial resistance and prevailing resistance mechanisms显示文摘 | Tanya S Vessela OR Boyka M | 2007 | J Med Microbiol2007，56，： | 1 |
| 8 | Dynamic capabilities, government policies, and performance in finns from emerging economies: evidence from India and Pakistan 显示文摘 | Malik OR Kotabe M | 2009 | Journal of Management Studies2009，46，3： | 1 |
| 9 | Safety and efficacy of donor lymphocyte infusions following mismatched stem cell transplantation显示文摘 | Or R Hadar E Bitan M | 2006 | Biol Blood Marrow Transplant2006，12，12： | 1 |
| 10 | Survival after laparoscopic surgery versus open surgery for colon cancer; long-term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group Buunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 11 | Hyperinsulinemia,sex,and risk of atherosclerotic cardiovascular disease显示文摘 | Modan M Or J Karasik A | 1991 | Circulation1991，84，： | 1 |
| 12 | Survival after laparoscopic Surgery versus open surgery for colon cancer, long - term outcome of a randomised clinical trial显示文摘 | Colon Cancer Laparoscopic or Open Resection Study Group guunen M Veldkamp R | 2009 | Lancet Oncol2009，10，1： | 1 |
| 13 | Effect o f microbial inoculants on quality of alfalfa hay baled at high moisture and cattle performance显示文摘 | Emanuele S M H or ton G M J Aldw in J | 1992 | J Dairy Sci1992，75，： | 1 |
| 14 | Acute changes in circulating natriu retic peptide level in relation to myocardial ischemia 显示文摘 | Sabatine MS M or row DA de Lemos JA | 2004 | J Am Coil Cardiol2004，44，： | 1 |
| 15 | Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain显示文摘 | Lorger M Krueger JS Or Neal M | 2009 | Proc Natl Acad Sci U S A2009，106，10： | 1 |
| 16 | Metabolic endotoxemia initiates obesity and insulin resistance 显示文摘 | Cani PD Amar J Iglesias MA Poggi M Knauf C Bastelica D Neyrinck AM Fava F Tuohy KM Chabo C Waget A Delm6e E Cousin B Sulpice T Chamontin B Ferrieres J Tanti JF Gibson OR Casteilla L Delzenne NM Alessi MC Burcelin R | 2007 | Diabetes2007，56，7： | 1 |
| 17 | Hydralazine-Induced Prevention of Nitrate Tolerance: Experimental and Clinical Evidence and Potential Mechanisms显示文摘 | Elkayam U Canetti M Wani OR | 1998 | Am J Cardiol1998，81，1： | 1 |
| 18 | Using the SETQ system to evaluate and improve teaching qualities of clinical teachers 显示文摘 | Lombarts M J Arah OA Busch OR | 2010 | Ned Tijdschr Geneeskd2010，154，： | 1 |
| 19 | Quantifying lateral root rein- forcement in steep slopes-from a bundle of roots to tree stands 显示文摘 | Schwarz M Lehmann P Or D | 2010 | Earth Surface Processes and Landforms2010，35，3： | 1 |
| 20 | Manganese nutrition effects on tomato growth, chlorophyll concentration, and superox-ide dismutase activity 显示文摘 | Shenker M Plessner 0 E Tel - Or E | 2004 | Journal of Plant Physiology2004，161，： | 1 |
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