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| 1 | Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis显示文摘AIM To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis(NASH) model influences surgical outcome.METHODS For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl_4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy(PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control. Each group was evaluated for survival rate, regeneration, apoptosis, necrosis and DNA expression after PH.RESULTS In the 70% PH of NASH group, the survival rate was significantly decreased compared with that in the control and 30% PH of NASH groups(P < 0.01). 10 of 32 mice in the NASH 70% PH group died within 48 h after PH. Serum aspartate aminotransferase(AST) levels and total bilirubin(T-Bil) in the NASH 70% PH group were significantly higher than the levels in the other two groups(AST: P < 0.05, T-Bil: P < 0.01). In both PH of NASH groups, signaling proteins involved in regeneration were expressed at lower levels than those in the control group(P < 0.01). The 70% PH of NASH group also exhibited a lower number of Ki-67-positive cells and higher rates of apoptosis and necrosis than the NASH 30% PH group(P < 0.01). In addition, DNA microarray assays showed differences in gene expression associated with cell cycle arrest and apoptosis.CONCLUSION The function of the residual liver is impaired in fatty liver compared to normal liver. A larger residual volume is required to maintain liver functions in mice with NASH. | Yusuke Ozawa Takafumi Tamura Yohei Owada Yoshio Shimizu Akira Kemmochi Katsuji Hisakura Takashi Matsuzaka Hitoshi Shimano Hiroko Isoda Nobuhiro Ohkohchi | 2018 | World Journal of Gastroenterology2018，24，15： | 2 |
| 2 | Increased incidence of non-insulin dependent diabetes mellitus among Japanese school children correlates with an increased intake of animal protein and fat显示文摘 | Kitagwa T Owada M Uraknd T | 1998 | Clin Pediatr1998，37，： | 1 |
| 3 | MCM-41 as a Highly Active Catalyst for Diels-Alder Reaction of Anthracene with p-Benzoquinone显示文摘 | Kugita T Ezawa M Owada T | 2001 | Mic Mes Mater2001，4445，： | 1 |
| 4 | Fatty acid binding protein: localization and functional significance in the brain显示文摘 | OWADA Y | 2008 | Tohoku J Exp Med2008，214，3： | 1 |
| 5 | Spherical carbon adsorbent (AST-120) protects deterioration of renal function in chronic kidney disease rats through inhibition ofreactive oxygen species production from mitochondria and reduction of serum lipid peroxidation显示文摘 | Owada S Maeba T Sugano Y | 2010 | Nephron Exp Nephrol2010，115，4： | 1 |
| 6 | Floral diagrams and inflorescences: Interactive flower modeling using botanical structural constraints显示文摘 | Ijiri T Owada S Okabe M | 2005 | ACM Transactions on Graph2005，24，3： | 1 |
| 7 | High fluorine pargasites in ultrahigh temperature granulites from Tonagh Island in the Archean Napier Complex,East Antarctica显示文摘 | Toshiaki Tsunogae Yasuhito Osanai Masaaki Owada | 2003 | Lithos2003，70，12： | 1 |
| 8 | Activation-induced accumulation of B and T lymphocyte attenuator at the immu- nological synapse in CD4^+ T cells显示文摘 | Owada T Watanabe N Oki M | 2010 | J Leukoc Biol2010，87，： | 1 |
| 9 | 'V-H-A Pattern' as a criterion for the differential diagnosis of atypical AV nodal reentrant tachycardia from AV re- ciprocating tachycardia显示文摘 | OWADA S IWASA A SASAKI S | 2005 | Pacing Clin Electrophysi- ol2005，28，： | 1 |
| 10 | Midkine inhibits apoptosis via extracellular signal regulated kinase (ERK) activation in PC12 cells显示文摘 | Owada K Sanjyo N Kobayashi T | 1999 | J Med Dent Sci1999，46，1： | 1 |
| 11 | The effects of bisoprolol,a selective betal-blocker,on glucose metabolism by long-term administration in essential hypertension显示文摘 | OWADA A SUDA S HATA T | 2001 | Clin Exp Hypertens2001，23，： | 1 |
| 12 | Spinal intramedul- lary tuberculoma requiring surgical treatment: Case report 显示文摘 | Miyamoto J Sasajima H Owada K | 2003 | Neurol MedChir2003，43，11： | 1 |
| 13 | Development of auto- immune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte atten- uator显示文摘 | Oya Y Watanabe N Owada T | 2008 | Arthritis Rheum2008，58，： | 1 |
| 14 | pharmacological properties of galenicai properations(XX) :Screening of natural products in Polyg- alae Radix 显示文摘 | Wang SS Saito Ken Owada E | 1995 | J Traditional Medicines1995，12，： | 1 |
| 15 | Volumetric illustration:designing 3D models with internal textures显示文摘 | Owada S Nielsen F Okabe M | 2004 | ACMTransactions on Graphics(TOG)2004，23，3： | 1 |
| 16 | The Assimilation of ATOVS Radiances in the JMA Global Analysis System 显示文摘 | OKAMOTO K KAZUMORI M OWADA H | 2005 | J Meteorol Soc Jpn2005，83，2： | 1 |
| 17 | Experimental Study of Coal Liberation: Electrical Disintegration Versus Roll - crusher Comminution 显示文摘 | M Ito S Owada T Ota | 2009 | International Journal of Mineral Process2009，92，7： | 1 |
| 18 | Interaction between desialylated hepatitis B virus and asialoglycoprotein receptor on hepatocytes may be indispensable for viral binding and entry显示文摘 | Owada T Matsubayashi K Sakata H | 2006 | J Viral Hepat2006，13，1： | 1 |
| 19 | Noninvasive mo- nitoring of 13 - cell mass and fetal β-cell genesis in mice using bioluminescence imaging 显示文摘 | Sekiguchi Y Owada J Oishi H | 2012 | Experimental Ani- mals2012，61，4： | 1 |
| 20 | Adaptive servoventilation improves cardiorenal function and prognosis in heart failure patients with chronic kidney disease and sleep-disordered breathing显示文摘 | Owada T Yoshihisa A Yamauchi H | 2013 | J Card Fail2013，19，4： | 1 |
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