|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 2 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 3 | Adjuvant therapy in pancreatic cancer显示文摘The outlook for patients with pancreatic cancer has been grim. There have been major advances in the surgical treatment of pancreatic csncer, leading to a drsmatic reduction in post-operative mortality from the development of high volume specialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in pancreatic cancer including chemoradiotherapy and chemotherapy. Initial protocols have been based on the original but rather small GITSG study first reported in 1985. There have been two large European trials totalling over 600 patients (EORTC and ESPAC-1) that do not support the use of chemoradiation as adjuvant therapy. A second major finding from the ESPAC-1 trial (541 patients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherapy. A third major finding from the ESPAC-1 trial was that the quality of life was not affected by the use of adjuvant treatments compared to surgery alone.The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients. | Paula Ghaneh John Slavin Robert Sutton Mark Hartley John P Neoptolemos | 2001 | World Journal of Gastroenterology2001，7，4： | 3 |
| 4 | EUS-guided single-incision needle-knife biopsy: description and results of a new method for tissue sampling of subepithelial GI tumors (with video)显示文摘 | Carlos de la Serna-Higuera Manuel Pérez-Miranda Pilar Díez-Redondo Paula Gil-Simón Teresa Herranz Elena Pérez-Martín C. Ochoa Agustín Caro-Patón | 2011 | Gastrointestinal Endoscopy2011，，3： | 2 |
| 5 | Carboxymethylation of cashew tree exudate polysaccharide显示文摘 | Silva D A de Paula R C Feitosa J P | 2004 | Carbohydrate Polymers2004，58，2： | 1 |
| 6 | Spectroscopic and Electrochemical Studies of Cocaine-Pioid Interac- tions显示文摘 | Garrido P Paula M Marques M | 2007 | Anal Bioanal Chem2007，388，17： | 1 |
| 7 | One-step RT-PCR protocols improve the rate of dengue diagnosis com- pared to two-step RT-PCR approaches显示文摘 | De Paula S O D Lima C D M Torres M P | 2004 | J Clin Virol2004，30，： | 1 |
| 8 | Finite element simulations of the clinch joining of metallicsheets显示文摘 | A-A de Paula AGUILAR M T P PERTENCE A E M | 2007 | Journal of Materials Processing Technology2007，182，： | 1 |
| 9 | Steady-state visual evoked potentials can be explained by temporal superposition of transient event-related responses显示文摘 | ALMUDENA C PAULA P A CAMPO P | 2011 | Plos One2011，6，14： | 1 |
| 10 | Enhanced lateral pressure tuning of fiber Bragg gratings by polymer packa- ging显示文摘 | Ngoia B K A Paula J Zhao L P | 2004 | Optics Communications2004，242，46： | 1 |
| 11 | Pioglitazone reverses downregulation of cardiac PPARγ expression in Zucker diabetic fatty rats 显示文摘 | Theo P Virginija J Paula A | 2005 | Biochem Biophysi Res Comm2005，329，2： | 1 |
| 12 | Visible photoluminescence of MWCNT/CdS nanohybrid structure synthesized by a simple chemical process显示文摘 | Paula Rima Kumbhakara P Mitre A K | | 0，，02： | 1 |
| 13 | Algal biochar- production and properties显示文摘 | Bird M I Wurster C M de Paula Silva P H | 2010 | Bioresouree Technology2010，102，2： | 1 |
| 14 | Proteinase activity and stability of natural bromelain preparations显示文摘 | Laura P Hale Paula K Greer Chau T Trinh | 2005 | International Immunopharmacology2005，，： | 1 |
| 15 | Low-grade myofibro-blastic sarcoma of the tongue 显示文摘 | Amrita J Kim P Paula M | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，104，5： | 1 |
| 16 | Screening of congenital cytomegalovirus infection by real-time PCR in urine pools 显示文摘 | Paix~o P Almeida S Paula A | 2012 | Euro- pean J Pediatr2012，171，1： | 1 |
| 17 | Socioeconomic status in health research: title and subtitle break one size doos not fit all显示文摘 | Paula A Braveman M M Catherine Cubbiu P Susan Ege-ler P et at | 2005 | jama-Journal of the American Medical Association2005，294，22： | 1 |
| 18 | Effects of water stress on the biosynthesis and degradation of polyunsaturated lipid molecular species in leaves of Vigna un- guiculata 显示文摘 | Monteiro de Paula F Thi anh thu P Zuily-Fodil Y | 1993 | Plant Physiology and Biochemistry1993，31，5： | 1 |
| 19 | Genetic control of the mitochondrial form of superoxide dismutase in hexaploid wheat显示文摘 | Paula R Neuman P R Hart G E | 1986 | Biochemical Genetics1986，24，56： | 1 |
| 20 | A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis显示文摘 | Paula Matesanz‐Pérez María García‐Gargallo Elena Figuero Antonio Bascones‐Martínez Mariano Sanz David Herrera | 2013 | J Clin Periodontol2013，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员