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| 1 | Treatment of inflammatory bowel disease:A review of medical therapy显示文摘Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract. While a cure remains elusive, both can be treated with medications that induce and maintain remission. With the recent advent of therapies that inhibit tumor necrosis factor (TNF) alpha the overlap in medical therapies for UC and CD has become greater. Although 5-ASA agents have been a mainstay in the treatment of both CD and UC, the data for their efficacy in patients with CD, particularly as maintenance therapy, are equivocal. Antibiotics may have a limited role in the treatment of colonic CD. Steroids continue to be the first choice to treat active disease not responsive to other more conservative therapy; non- systemic steroids such as oral and rectal budesonide for ileal and right-sided CD and distal UC respectively are also effective in mild-moderate disease. 6-mercaptopurine (6-MP) and its prodrug azathioprine are steroid-sparing immunomodulators effective in the maintenance of remission of both CD and UC, while methotrexate may be used in both induction and maintenance of CD. Infliximab and adalimumab are anti-TNF agents approved in the US and Europe for the treatment of Crohn's disease, and infliximab is also approved for the treatment of UC. | Patricia L Kozuch Stephen B Hanauer | 2008 | World Journal of Gastroenterology2008，14，3： | 21 |
| 2 | Incidence and risk factors for early renal dysfunction after liver transplantation显示文摘AIM: To determine renal dysfunction post liver transplantation, its incidence and risk factors in patients from a Belgian University Hospital.METHODS: Orthotopic liver transplantations performed from January 2006 until September 2012 were retrospectively reviewed(n = 187). Patients with no renal replacement therapy(RRT) before transplantation were classified into four groups according to their highest creatinine plasma level during the first postoperative week. The first group had a peak creatinine level below 12 mg/L, the second group between 12 and 20 mg/L, the third group between 20 and 35 mg/L, and the fourth above 35 mg/L. In addition, patients who needed RRT during the first week after transplantation were also classified into the fourth group. Perioperative parameters were recorded as risk factors, namely age, sex, bodymass index(BMI), length of preoperative hospital stay, prior bacterial infection within one month, preoperative ascites, preoperative treatment with β-blocker, angiotensin-converting enzyme inhibitor or non steroidal anti-inflammatory drugs, preoperative creatinine and bilirubin levels, donor status(cardiac death or brain death), postoperative lactate level, need for intraoperative vasopressive drugs, surgical revision, mechanical ventilation for more than 24 h, postoperative bilirubin and transaminase peak levels, postoperative hemoglobin level, amount of perioperative blood transfusions and type of immunosuppression. Univariate and multivariate analysis were performed using logistic ordinal regression method. Post hoc analysis of the hemostatic agent used was also done.RESULTS: There were 78 patients in group 1(41.7%), 46 in group 2(24.6%), 38 in group 3(20.3%) and 25 in group 4(13.4%). Twenty patients required RRT: 13(7%) during the first week after transplantation. Using univariate analysis, the severity of renal dysfunction was correlated with presence of ascites and prior bacterial infection, preoperative bilirubin, urea and creatinine level, need for surgical revision, use of vasopressor, postoperative mechanical ventilation, postoperative bilirubin and urea, aspartate aminotransferase(ASAT), and hemoglobin levels and the need for transfusion. The multivariate analysis showed that BMI(OR = 1.1, P = 0.004), preoperative creatinine level(OR = 11.1, P < 0.0001), use of vasopressor(OR = 3.31, P = 0.0002), maximal postoperative bilirubin level(OR = 1.44, P = 0.044) and minimal postoperative hemoglobin level(OR = 0.059, P = 0.0005) were independent predictors of early post-liver transplantation renal dysfunction. Neither donor status nor ASAT levels had significant impact on early postoperative renal dysfunction in multivariate analysis. Absence of renal dysfunction(group 1) was also predicted by the intraoperative hemostatic agent used, independently of the extent of bleeding and of the preoperative creatinine level.CONCLUSION: More than half of receivers experienced some degree of early renal dysfunction after liver transplantation. Main predictors were preoperative renal dysfunction, postoperative anemia and vasopressor requirement. | Patricia Wiesen Paul B Massion Jean Joris Olivier Detry Pierre Damas | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 3 | Leukocyte driven-decidual angiogenesis in early.pregnancy显示文摘成功的怀孕并且长期,出生后母亲并且后代心脏、脉管、新陈代谢的健康在怀孕期上要求关键母亲的心血管的改编。在怀孕 decidualizing 子宫以内,协调了脉管,免疫学的和 stromal 房间变化发生。可观的注意在开始蜕膜的螺线被给了房间到子宫的生来的杀手(uNK ) 的角色动脉的改变,通常完成由的一个过程在老鼠并且在人中间怀孕期。然而,白血球角色在早得多,区域特定,蜕膜的脉管的改变现在正在被定义。对免疫者的兴趣支持房间的脉管的改变被在象不孕,周期性的自发的流产, preeclampsia (PE ) 和胎儿的生长限制那样的人的 gestational 复杂并发症被报导的脉管的错误驾驶。适当母亲的心血管的回答在怀孕期间保护母亲和他们的孩子免受以后的心血管的疾病风险举起的伤害。对在有 hemochorial 胎座式的种类的怀孕的最早子宫的回答之一是 stromal 细胞 decidualization,它为 angiogenesis 和白血球招募创造唯一的壁龛。在早蜕膜 basalis,将抱发展中的胎盘并且提供主要的血容器支持成熟胎盘的功能的培植地点的方面,白血球极大地被充实并且显示专业化性质。UNK 房间,在早蜕膜 basalis 的最丰富的白血球子集,有 angiogenic 能力并且为正常早蜕膜的 angiogenesis 是必要的。在决定的 uNK 房间和他们的角色的规定母亲并且子孙在怀孕上的心血管的健康并且产后被讨论。 | Patricia DA Lima Jianhong Zhang Caroline Dunk Stephen J Lye B Anne Croy | 2014 | Cellular & Molecular Immunology2014，11，6： | 8 |
| 4 | Induced pluripotent stem cells for modeling neurological disorders显示文摘Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism. | Fabiele B Russo Fernanda R Cugola Isabella R Fernandes Graciela C Pignatari Patricia C B Beltrão-Braga | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 5 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 6 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 7 | G,Katherine A D,Beth L,J,Quality of life in long-term,disease-free survivors of breast cancer:a follow-up study显示文摘 | Patricia B A | 2002 | Journal of the National Cancer Institute2002，1，94： | 1 |
| 8 | Determination of Clenbuterol,Ractopamine and Zilpaterol in Liver and Urine by Liquid Chromatography Tandem Mass Spectrometry显示文摘 | Jose B Patricia M Miguel M | 2005 | Aanl Chim Acta2005，529，： | 1 |
| 9 | Being Big or Growing Fast;a systematic review of size and growth in infancy and later obesity 显示文摘 | JANIS B DAVID F PATRICIA L | 2005 | Bmj2005，331，7522： | 1 |
| 10 | Human a-defensins block papillornavirus infection 显示文摘 | Christopher B Buck Patricia M Day Cynthia D Thompson | 2006 | PNAS2006，103，5： | 1 |
| 11 | Large-scale HCV RNA screening in first time blood donors: the first step towards genomic screening of blood donations显示文摘 | Juraj P Patricia H John B | 1999 | Vox Sang1999，76，3： | 1 |
| 12 | Structural mechanism for STI571 inhibition of Abelson tyrosine kinase显示文摘 | Thomas S William B Patricia P | 2000 | Science2000，289，15： | 1 |
| 13 | Quantitative conversion of phytate to inorganic phosphorus in soybean seeds expressing a bacterial phytase显示文摘 | Peiyu Z Patricia C | 2008 | Plant Physiology2008，146，2： | 1 |
| 14 | 64-Row mul tidetector CT virtual hysero-salpingography显示文摘 | Patricia C CarlosC Mariano B | 2009 | Abdom Imaging2009，34，： | 1 |
| 15 | Nitrate in drinking water and the incidence of gastric,esophageal,and brain cancerin Yorkshire,England显示文摘 | Jennifer H B Roger C P Patricia A M | 1998 | Cancer Causes and Control1998，，9： | 1 |
| 16 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis W Larry O Patricia B | 1999 | Ecological Economics1999，29，： | 1 |
| 17 | Cultural competence in mental health care: A review of model evaluations显示文摘 | Kamaldeep B Nasir W Patricia E | 2007 | BMC Health Service Research2007，7，： | 1 |
| 18 | Preparation, characterization and reactivity of V-and/or co-containing AlPO- 18 materials (VCoAPO-18) in the oxidative dehydrogenation of ethane 显示文摘 | PATRICIA C TERESA B JOSE M L N | 2004 | Micropor Mesopor Mater2004，67，23： | 1 |
| 19 | Acquired autoimmune thrombocytopenia after allogeneic bone marrow transplantation 显示文摘 | Philippe B Catherine C Patricia F | 1985 | British Journal of Haematology1985，59，： | 1 |
| 20 | Analysis of sugars inenvironmental samples by gas chromatography-mass spectrometry显示文摘 | PATRICIA M M SIMONEIT B R | 2007 | Journal of Chromatograph A2007，1141，： | 1 |
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