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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Simultaneous preperitoneal hernia repair duringradical pelvic surgery显示文摘 | Patrick C W | 1987 | J Urol1987，137，6： | 1 |
| 3 | Toward a unifying framework for exploring fit and flexibility in strategic human resource management显示文摘 | Patrick M W & Scott A S | 1998 | Academy of management review1998，23，： | 1 |
| 4 | Conservative management of thoracolumbar and lumbar spine eompression and burst fractures:functional and radiographic outcomes in 136 cases treated by closed reduction and casting显示文摘 | Patrick W Arthur S Harald H | 2009 | Arch Orthop Trauma surg2009，129，： | 1 |
| 5 | Collagen stimula- ting factors from lung in experimental paraquat poi- soning demonstrated in vitro and in vivo显示文摘 | THOMPSON W D PATRICK R S | 1984 | J Clin Pathol1984，37，： | 1 |
| 6 | Near infrared spectroscopy in patient with sever brain injury and elevated ICP:a pilot study显示文摘 | Melville S Mark G | 1997 | Acta Neurochir Suppl(wien)1997，70，1： | 1 |
| 7 | Desulfurization of Fuel Oil by Oxidation and Extraction 显示文摘 | Patrick S T James R K John W E | 1990 | Industrial & Engineering Chemist Research1990，29，3： | 1 |
| 8 | Final contractor se- lection using the analytical hierarchy process 显示文摘 | PATRICK S W F SONIA K Y C | 2000 | Construction Management and Economics2000，18，5： | 1 |
| 9 | 5-Nitro-2-thiophene-aldehyde显示文摘 | Patrick T M Emerson W S | 1952 | J Am Chem Soc1952，74，： | 1 |
| 10 | The B73 maize genome: complexity, diversity, and dynamics显示文摘 | Patrick S S Doreen W Robert S F | 2009 | Science2009，326，： | 1 |
| 11 | Transformation of manganese in a water- logged soll as affected by redox potential and pH显示文摘 | Gotoch S and W H Patrick | 1972 | PSSSA1972，36，： | 1 |
| 12 | Transformation d iron in a waterlogged soil as influenced by redox potential and pH 显示文摘 | Gotoh S Patrick W H | 1974 | Soil Sci Soc Am Proc1974，38，： | 1 |
| 13 | Effect of salinity on leaf ionic content and photosynthesis of Taxodium distichum显示文摘 | Pezeshki S R DeLaune R D Patrick W H Jr | 1988 | American Midland Naturalist1988，119，1： | 1 |
| 14 | Psychology doctoral training in work and health显示文摘 | RAYMOND J S WOOD D W PATRICK W D | 1990 | American Psychologist1990，，10： | 1 |
| 15 | Differential response of selected mangroves to soil flooding and salinity: gas exchanges and biomass partitioning显示文摘 | PEZESHKI S R DELAUNE R D PATRICK W H Jr | 1989 | Can J For Res1989，20，： | 1 |
| 16 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 17 | A Model of HIV-I Pathogenesis that Includes an Intracellular Delay 显示文摘 | Patrick W Nelson James D Murray Alan S Perelson | 2000 | Mathematical Biosciences2000，163，2： | 1 |
| 18 | Differential response of selected mangroves to soil flooding and salinity: Gas exchangesand biomass partitioning显示文摘 | Pezeshki S R Delaune R D Patrick W H Jr | 1989 | Canadian Journal of Forest Research1989，20，： | 1 |
| 19 | Desulfurization of fuel oil by oxidation and extraction显示文摘 | Patrick S T James R K John W E | 1990 | Industrial & engineering chemistry research1990，29，3： | 1 |
| 20 | Antimutagenic effect of rat small intestine in vitro on 1,1,2,3-tetrachloro- propene and 1,1,2,3,3-pentachloropropene 显示文摘 | Joseph S Patrick R D Michael W N | 1984 | Cancer Let- ters1984，22，3： | 1 |
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