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| 1 | 新生儿心电图判读指南(二)显示文摘 | 魏丽 周同甫 Schwartz PJ Garson A Jr Paul T | 2009 | 中华妇幼临床医学杂志(电子版)2009，5，1： | 4 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | G蛋白信号转导调节因子5的缺失激活脑卒中时的神经血管保护显示文摘在缺血性脑卒中发生时,血脑屏障的破坏加重了脑损伤。周细胞脱离导致血脑屏障破坏和神经血管功能障碍,但对其在脑卒中中的调节知之甚少。在该研究中,研究者研究了周细胞中G蛋白信号转导调节因子5(Gprotein signaling5,RGS5)的缺失如何影响脑卒中时血脑屏障的破坏及其后果。 | zen I Roth M Barbariga M Gaceb A Deierborg T Genové G Paul G 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 2 |
| 4 | 新生儿心电图判读指南(一)显示文摘 | Schwartz PJ Garson A Jr Paul T 魏丽 周同甫 | 2008 | 中华妇幼临床医学杂志(电子版)2008，4，6： | 2 |
| 5 | Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study显示文摘 | Henry Krum Markus Schlaich Rob Whitbourn Paul A Sobotka Jerzy Sadowski Krzysztof Bartus Boguslaw Kapelak Anthony Walton Horst Sievert Suku Thambar William T Abraham Murray Esler | 2009 | The Lancet2009，，9671： | 2 |
| 6 | Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study显示文摘 | Henry Krum Markus Schlaich Rob Whitbourn Paul A Sobotka Jerzy Sadowski Krzysztof Bartus Boguslaw Kapelak Anthony Walton Horst Sievert Suku Thambar William T Abraham Murray Esler | 2009 | The Lancet . 2009 (9671)2009，，9671： | 2 |
| 7 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 8 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 9 | Stabilization mechanisms of soil organic matter: Implications for C-saturation of soils显示文摘 | Six J Conant R T Paul E A | 2002 | Plant Soil2002，241，： | 1 |
| 10 | Azepinone as a conformational constraint in the design of κ opioid receptor agonists显示文摘 | Paul A T Pamela R S William B | 2004 | Bioorg Med Chem Lett2004，14，22： | 1 |
| 11 | Metabolism of chlorogenic acid by human plasma, liver,intestine and gut microflora显示文摘 | Geoff W Plumb Maria T Gareia-Conesa Paul A Kroon | 1999 | J Sci Food Agric1999，79，： | 1 |
| 12 | Cloud Computing Security: Opportunities and PiffaUs显示文摘 | JUNAID A PAUL T | 2012 | International Journal of Grid and High Performance Computing2012，，4： | 1 |
| 13 | Stabilization mechanisms of soil organic matter:Implications for C-saturation of soils显示文摘 | Six J Conant R T Paul E A | 2002 | Plant and Soil2002，241，2： | 1 |
| 14 | Tensile strength of a closed-cell A1 foam in the presence of notches and holes 显示文摘 | PAUL A SESHACHARYULU T RAMAMURTY U | 1999 | Scripta Mater1999，40，7： | 1 |
| 15 | Extraction and char- actefization of humus with reference to clay-associated humus显示文摘 | Anderson D W Paul E A Arnaud R J S T | 1974 | Can J Soil Sci1974，54，3： | 1 |
| 16 | Radiofrequency catheter ablation in small children : relationship of complications to application dose 显示文摘 | Blaufox A D Paul T Saul J P | 2004 | Pacing Clin Electrophysiol2004，27，2： | 1 |
| 17 | Invasion of bladder by t ramsitional cell carcinoma显示文摘 | Robin T Peter A Paul E | 1998 | Cancer1998，82，： | 1 |
| 18 | Implications of harmonizing the future of the federal depository library program within e- government principles and policies 显示文摘 | John A Shuler Paul T Jaeger John Carlo Bertot | 2010 | Government Information Quarterly2010，27，1： | 1 |
| 19 | Static and dynamic behaviour of soils: a rational approach to quantitative solutions, Part I: Fully saturated problems显示文摘 | Zienkiewicz O C Chart A H C Pastor M Paul D K Shiomi T | 1990 | Proc R Soc London1990，429，： | 1 |
| 20 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
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