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| 1 | Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord显示文摘The aim of this work was to study effects of ketotifen fumarate(KF)on prevention of tissue damage in testes of rats with experimental autoimmune orchitis(EAO)and on the contralateral testis in a model of prolonged testicular cord torsion(TCT).Rats with EAO or TCT were injected intraperitoneally once daily with KF or saline solution(vehicle group).Incidence and severity of testicular damage were evaluated by histopathology using an EAO score or a Johnsen score.Mast cells(MC)were identified by histochemistry and quantified.In EAO model,KF significantly reduced severity of histopathological testicular damage compared to rats in the vehicle group.KF also reduced the number of testicular MC compared to vehicle group.Similarly,in TCT model,multifocal damage of the contralateral testis was observed 30 days after testicular torsion characterized by sloughing of the germinal epithelium,seminiferous tubule atrophy,and interstitial edema.Focal signs of inflammation and fibrosis of seminiferous tubular walls were also observed.In contrast,sections of contralateral testis of rats injected with KF and killed 30 days after surgery showed normal histological features.A significant decrease in the number of MC was observed in rats treated with KF compared to untreated animals.In conclusion,we demonstrated that treatment with KF reduced testicular inflammatory process and MC infiltrates in both EAO and TCT models.The results suggest a promising treatment for infertile male patients with testicular pathologies associated with inflammation and germ cell loss. | Diego Moreno Cristian M Sobarzo Livia Lustig Marcelo G Rodriguez Pena Vanesa Anabella Guazzone | 2020 | Asian Journal of Andrology2020，22，1： | 3 |
| 2 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 3 | NKX3.1和Prostein在睾丸组织和性索间质肿瘤中的表达显示文摘众所周知,前列腺癌可转移到睾丸,并且在晚期疾病的去势术中较为常见。尽管生殖细胞肿瘤占睾丸肿瘤的大多数,但还有更多罕见的肿瘤可以模拟转移性疾病,如睾丸网腺癌。NKX3.1和Prostein是对前列腺来源高度特异性的抗体,目前两者在睾丸组织中的表达了解相对较少。 | Arnesen C Eich M L Pena M R 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，1： | 2 |
| 4 | Optimization of the matrix solid-phase dispersion sample preparation procedure for analysis of polycyclic aromatic hydrocarbons in soils: Comparison with microwave-assisted extraction显示文摘 | Pena M T Casals M C Mejuto M C | 2007 | Journal of Chromatography A2007，1165，： | 1 |
| 5 | Partial oxidation of methanol to produce hydrogen over Cu-Zn-based catalysts 显示文摘 | Alejo L Lago R Pena M A | 1997 | Appl Catal A1997，162，12： | 1 |
| 6 | Transient left ventricular apical ballooning and outflow tract obstruction 显示文摘 | Penas - Lado M Barriales - Villa R Goicolea J | 2003 | J Am Coll Cardiol2003，42，11： | 1 |
| 7 | A three-dimensional finite element analysis of the combined behavior of ligaments and menisci in the healthy human knee joint 显示文摘 | Pena E Calvo B Martinez M A | 2006 | Journal of Biomechanics2006，39，9： | 1 |
| 8 | Shape preserving alternatives to the rational Bezier model显示文摘 | Mainar E Pena J M Sanchez-Reyes J | 2001 | Computer Aided Geometric Design2001，18，1： | 1 |
| 9 | Constitutive expression of Arabidopsis LEAFY or APETALA1 genes in citrus reduces their generation time显示文摘 | PENA L MARTIN-TRILLO M JUAREZ J | 2001 | Nature Biotechnology2001，，19： | 1 |
| 10 | Shape preserving alternatives to the rational Bezier model显示文摘 | Main E Pena J M Sanchez-Reyes J | 2001 | Computer Aided Geometric Design2001，18，1： | 1 |
| 11 | The role of a dechlorinated PVC as compatibiliser for PVC/polyethylene blends显示文摘 | A Zarraga M E Munoz J J Pena | 2002 | Polymer Bulletin2002，，3： | 1 |
| 12 | Doubly fed induction generator using back- to- back PWM converters and its application to variable speed wind- energy generation显示文摘 | Pena R Clare J C Asher G M | 1996 | Electric Power Applications IEE Proceedings1996，143，3： | 1 |
| 13 | Determination of total and specific IgE using UNICAP 100:comparative study with the CAP system显示文摘 | Cots P Pena J M Botey J | 1998 | Allergol & Immunopathol1998，26，1： | 1 |
| 14 | Doubly fed induction generator using back-to-back PWM converters and its application to variable speed wind-energy generation显示文摘 | Pena R Clare J C Asher G M | 1996 | IEE Proc Electrical Power Application1996，143，3： | 1 |
| 15 | The application of exosomes as a nanoscale cancer vaccine 显示文摘 | Tan A H De La Pena Seifalian A M | 2010 | Int J Nanomedicine2010，5，： | 1 |
| 16 | Occurrence Of Fumonisins B1 And B2 In Portuguese Maize And Maize-Based Foods Intended For Human Consumption显示文摘 | Silva L Lino C M Pena A | 2007 | Food Addit Contam2007，24，4： | 1 |
| 17 | A Doubly Fed Induction Generator Using back-to-back PWM Converters SupplyingAn Isolated Load From A Variable Speed Wind Turbine显示文摘 | PENA R CLARE J C ASHER G M | 1996 | IEEE Proceeding on Electric Power Application1996，143，5： | 1 |
| 18 | A natural antisense transcript regulates Zeb2/Sipl gene expression during Snaill-induced epithelial-mesenchymal transition 显示文摘 | Beltran M Puig I Pena C | 2008 | Genes & Development2008，22，6： | 1 |
| 19 | Subacute combined degeneration of the spinal cord: MR findings显示文摘 | Penas M Blanco A Villarejo A | 2002 | Neurologia2002，17，8： | 1 |
| 20 | Determination of organochlorine pesticide residues in honey from the central zone of Portugal and the Valencian community of Spain 显示文摘 | Blasco C Lino CM Pico Y Pena A Font G Silveira M I N | 2004 | Journal of Chromatography A2004，1049，12： | 1 |
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