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| 1 | Mechanical thrombectomy in patients with M1 occlusion and NIHSS score≤5:a single-centre experience显示文摘Background:The recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke.However,it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale(NIHSS)≤5.We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.Methods:We retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016.We identified 41 patients with confirmed M1 occlusion and low NIHSS(≤5)on admission to our hospital.We collected demographic,radiological,procedural and outcome data.Results:The mean age of patients was 72±14,with 20 male patients.Associated medical conditions were common with hypertension seen in∼80%.Just over 50%presented with NIHSS 4 or 5.The average ASPECTS score on admission was 8.8(range 6–10),and the average clot length 10 mm.Angiographically Thrombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients had haemorrhage on follow-up,2 of which were symptomatic.Of 40 patients with 90-day follow-up,75%had modified Rankin Scale(mRS)score 0–2.There were 3 deaths at 90 days.Conclusions:Mechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile.Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy. | P Bhogal P Bucke O Ganslandt H Bazner H Henkes M Aguilar Perez | 2016 | Stroke & Vascular Neurology2016，1，4： | 9 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 4 | Micropropagation of 21 species of Moxican cacti by axillary proliferation显示文摘 | Perez M B Perez E Villalobos A M E | 1998 | In Vitro Cellular & Developmental Biology Plant1998，34，2： | 2 |
| 5 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 6 | Selectively permeable dendrimers as molecular gates显示文摘 | Gregory P Perez Richard M Crooks | 2001 | Interface2001，10，： | 2 |
| 7 | Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence显示文摘BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related mortality.Classifying clinical parameters that increase risk for recurrence after IBTR remains a challenge.AIM To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease outcomes.METHODS Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our institution.Overall survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan Meier method.We identified patients who experienced an isolated IBTR.Concordance of hormone receptor status and location of tumor from primary to recurrence was evaluated.The effect of clinical and treatment parameters on disease outcomes was also evaluated.RESULTS We identified 2164 patients who met the eligibility criteria.The median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]years.Five-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 IBTRs.We identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ component.Median time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)years.Radiotherapy information was available for 30 of 37 patients.Median whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor bed.Twenty-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly associated.There were no observed changes in HER-2 status from primary to IBTR.The concordance between quadrant of primary to IBTR was 10/19[(62.2%),P=0.008].Tumor size greater than 1.5 cm(HR=0.44,95%CI:0.22-0.90,P=0.02)and use of endocrine therapy upfront(HR=0.36,95%CI:0.18-0.73,P=0.004)decreased the risk of IBTR.CONCLUSION Among patients with early stage breast cancer who had breast conserving surgery treated with adjuvant RT,ER/PR status and quadrant were highly concordant from primary to IBTR.Tumor size greater than 1.5 cm and use of adjuvant endocrine therapy were significantly associated with decreased risk of IBTR. | Juhi M Purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber | 2020 | World Journal of Clinical Oncology2020，11，1： | 2 |
| 8 | Cytotoxic constituents from daphnia pulex 显示文摘 | Perez Gutierrez R M Lule P R | 2005 | Pharmaceutical Biology2005，43，4： | 1 |
| 9 | Cloning and functional analysis of the gene encoding the 332 to 362 kilodalton outer membrane protein associated with carbapenem resistance in Acinetobacter baumannii显示文摘 | Tomas M D M Beceiro A Perez A etal | 2005 | Antimicrob Agents Chemother2005，49，12： | 1 |
| 10 | Novel process for low temperature crystallization of a-SiC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，： | 1 |
| 11 | Mechanism of reduced susceptibility to amoxicillin -clavulanic acid in Escherichia coli strains from the health region of Tortosa ( Catalonia, Spain) 显示文摘 | Perez M O Perez -Moreno M Carulla M | 2004 | Clin Microbiol Infect2004，10，： | 1 |
| 12 | Influence of killer yeast strains of Saccharomyces cerevisiae on wine fermentation显示文摘 | PEREZ F RAMIREZ M | 2001 | Int J Gen Mol Microbiol2001，79，： | 1 |
| 13 | Abacavir dose not influence the rate of sustained virological response in HIV-HCV co- infected patients treated with pegylated interferon and weight adjusted ribavirin显示文摘 | Laufer N Laguno M Perez I | 2008 | Antivir Ther2008，13，7： | 1 |
| 14 | Non-toxic alternative compounds for marine antifouling paints显示文摘 | Stupak M E Garcia M T Perez M C | 2003 | International Biodeterioration & Biodegradation2003，52，1： | 1 |
| 15 | Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘 | Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
| 16 | Coloring of titanium through laser oxidation: Comparative study with anodizing 显示文摘 | Perez Del P Ferndndez-Pradas J M Serra P | 2004 | Surface and Coatings Technology2004，187，1： | 1 |
| 17 | Radiation therapy morbidity in carcinoma of the uterine cervix: Dosimetric and clinical correlation显示文摘 | PEREZ C A GRIGSBY P W LOCKETr M A | 1999 | Int J Radiat Oncol Biol Phys1999，44，4： | 1 |
| 18 | Inheritance of tomato yellow leaf curl virus resistance derived from Solanum pimpinellifolium UPV16991显示文摘 | Perez de C A Dlez M J Nuez F | 2007 | Plant Dis2007，91，7： | 1 |
| 19 | Computation of the RCS of Complex Bodies Modeled Using NUBBUS Surfaces显示文摘 | Domingo M M Rivas F Perez J | 1995 | IEEE Antennas and Propagation Magazine1995，37，6： | 1 |
| 20 | Rhesus rotavirus-based quadrivalent vaccine is efficacious despite age, socioeconomic conditions and seasonality in Venezuela显示文摘 | Eglee Perez M Glass R Alvarez G | 2000 | Vaccine2000，19，78： | 1 |
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