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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | On the optimization of compliant force amplifier mechanisms for surface micromachined resonant accelerometers显示文摘 | Pedersen C B W Seshia A A | 2004 | Journal of Micromechanics and Microengineering2004，，14： | 1 |
| 3 | Kidney dimensions at sonography: correlation with age, sex, and habitus in 665 adult volunteers 显示文摘 | EMAMIAN S A NIELSEN M B PEDERSEN J F | 1993 | AJR Am J Roentgen- ol1993，160，1： | 1 |
| 4 | Interleukin - 6 release from human skeletal muscle during exercise : relation to AMPK activity显示文摘 | MacDonald C Wojtassewski JF Pedersen BK Kiens B Richter EA | 2003 | J Appl Physio120032003，，： | 1 |
| 5 | Solid state characterization of a dry emulsion:A potential drug delivery system 显示文摘 | Pedersen G P Faldt P Bergenstahl B | 1998 | Int J Pharm1998，171，： | 1 |
| 6 | Pyrolytic disintegration of seletcted tobacco constituents and pyrosynthetic formation of aromatic hydrocarbons from cleavage products formed by pyrolysis显示文摘 | Lam J Pedersen B O Thomasen T | 1985 | Beitr Tabakfor Int1985，13，： | 1 |
| 7 | Effect of dietary fiber intake on blood pressure:a meta-analysis of randomized,controlled dlinical trial显示文摘 | Whelton SP Hyre AD Pedersen B | 2005 | J Hypertens2005，23，3： | 1 |
| 8 | Thermolysin catalyses the synthesis of cyclodextrin esters in DMSO显示文摘 | Pedersen N R Kristensen J B Bauw G | 2005 | Tetrahedron:Asymmetry2005，16，3： | 1 |
| 9 | The gradient tensor of potential field anomalies: Some implications on data collection and data processing of maps 显示文摘 | Pedersen L B Rasmussen T M | 1990 | Geophysics1990，55，12： | 1 |
| 10 | Removing bitterness from protein hydrolysates显示文摘 | PEDERSEN B | | 0，，10： | 1 |
| 11 | Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue(AT):implication of macrophages resident in the AT显示文摘 | BRUUN J M LIHN A S PEDERSEN S B | | 0，，： | 1 |
| 12 | MDS and AML with trisomy 8 as the sole chromosome aberration show different sex ratios and prognostic profiles: a study of 115 published cases显示文摘 | Pedersen B | 1997 | Am J Hematol1997，56，4： | 1 |
| 13 | Reproducibility of MRI renal artery blood flow and BOLD measurements in patients with chronic kidney disease and healthy controls显示文摘 | Khatir DS Pedersen M Jespersen B | 2013 | J Magn Re- son Imaging2013，，： | 1 |
| 14 | Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle显示文摘 | PLOUG T STALLKNECHT B M PEDERSEN O | 1990 | Am J Physiol1990，，259： | 1 |
| 15 | Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women显示文摘 | Ottesen B Pedersen B Nielsen J | 1987 | Peptides1987，8，5： | 1 |
| 16 | An integrated numerical model of the spray forming process 显示文摘 | Pryds N H Hattel J H Pedersen T B | 2002 | Acta Materialia2002，50，： | 1 |
| 17 | Effects of eccentric cycling exercise on IGF-Ⅰ splice variant expression in the muscles of young and elderly people 显示文摘 | Hameed M Toft A D Pedersen B K | 2008 | Scand J Med Sci Sports2008，18，4： | 1 |
| 18 | Evidence for prescribing exercise as therapy in chronic disease显示文摘 | Pedersen BK Saltin B | 2006 | Scand J Med Sci Sports2006，16，1： | 1 |
| 19 | Exercise and cytokines with particular focus on muscle-derived IL-6 显示文摘 | PEDERSEN B K STEENSBERG A FISCHER C | 2001 | Exe Imm Rev2001，7，： | 1 |
| 20 | Removing Bitterness from Protein Hydrolysates 显示文摘 | PEDERSEN B | 1994 | Food Tech1994，10，： | 1 |
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