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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Causes cortical brain slices during hypoxia and ischemic: role of ion channels and membrane damage显示文摘 | PHILIP E BICKER M BONN of calcium accumulation in rat C M | 1994 | Brain Res1994，665，2： | 1 |
| 3 | Cold-shock treatment of mature green toma- toes delay color development and increase shelf-life during room tem- perature storage显示文摘 | INABA M PHILIP G C | 1986 | Proceedings of the Florida State Horticultural Society1986，99，： | 1 |
| 4 | Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene Activation 显示文摘 | Maira M Martens C Philips A | 1999 | Mol Cell Biol1999，19，11： | 1 |
| 5 | A- nalysis of behavior-related adverse experiences in clini- cal trials of montelukast显示文摘 | PHILIP G HUSTAD C M MALICE M P | 2009 | J Allergy Clin Immunol2009，124，： | 1 |
| 6 | Fractal analysis of hydroxyapatite from nitrogen isotherms显示文摘 | E1 Shafei G M S Philip C A Moussa N A | 2004 | Journal of Colloid and Interface Science2004，277，2： | 1 |
| 7 | Human Bcl-2 protects against AMPA receptor-mediated apoptosis 显示文摘 | Nam S C Philip M B Catherine J P | 2000 | Neurochem2000，74，4： | 1 |
| 8 | Unusual segregation products in sperm from a pericentric inversion 17 heterozygote 显示文摘 | Monica M Mikhaail- Philips /EBarbara C McGillivray Sara J | 2005 | Hum Genet2005，117，： | 1 |
| 9 | Pathophysiologic process underlying emotion triggering acute cardiac even显示文摘 | Philip C Kesson M Daisy L | 2006 | Am J Bio Scipsych2006，103，11： | 1 |
| 10 | Oil-soluble Mo-S compounds as lubricant additives显示文摘 | PHILIP C H M | 1984 | Wear1984，100，13： | 1 |
| 11 | Investigation of the attachment of Thiobacillus ferrooxidans to mineral sulfides using scanning elctron microscopy analysis显示文摘 | SAMPSON M L PHILIPS C V BALL A S | 2000 | Minerals Engineering2000，13，： | 1 |
| 12 | Consumption Visions in Consumer Decision Making显示文摘 | PHILIPS D M OLSON J C BAUMGARTNER H | 1995 | Advances in Consumer Research1995，，22： | 1 |
| 13 | Resistin and type 2 diabetes:regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes显示文摘 | Philip G Mcternan C L Ffolliott M | 2003 | Clin Endocrinol Metab2003，88，12： | 1 |
| 14 | Correlated network data publication via differential privacy 显示文摘 | CHEN R FANG B C M PHILIP S Y | 2014 | The VLDB Journal2014，23，4： | 1 |
| 15 | Pathophysiological process underlying emotion triggering acute cardiac event显示文摘 | Philip C Kesson M Daisy L etal | 2006 | Am J Bio Sci Psych2006，11，： | 1 |
| 16 | The Structure and Evolution of Industrial Clusters:Transactions,Technology and Knowledge Spillovers显示文摘 | Simona I Philip M C | 2006 | Research Policy2006，，35： | 1 |
| 17 | Influence of base metals on the oxidizing ability of acidophilic bacteria during the oxidation of ferrous sulfate and mineral sulfide concentrates,using mesophiles and moderate thermophiles显示文摘 | Philips C V | 2001 | Minerals Engineering2001，14，3： | 1 |
| 18 | Development of spematozoa in the rhea显示文摘 | Philips D M Asa C S | 1989 | Anatomical Record1989，223，： | 1 |
| 19 | Phase Ⅱ study of erlotinib in patients with advanced biliary cancer 显示文摘 | Philip P A Mahoney M R Allmer C | 2006 | J Clin Oncol2006，24，19： | 1 |
| 20 | Characterisation of pea cytosolic glutathione reductase expressed in transgenic tobacco显示文摘 | Rebecca G S Gary P C Philip M M | 2000 | Planta2000，211，： | 1 |
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