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	题名	作者	年代	出处	被引量
1	Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells显示文摘AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth.METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death,flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 (COX-2),p21 and bcl-2 in cells incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 (PGE2) generation in the presence of AA and DHA was measured using a PGE2-ELISA.RESULTS:AA increased cell growth,whereas DHAreduced viability of LS 174T cells in a time-and dose-dependent manner. Furthermore,DHA down-regulated mRNA of bcl-2 and up-regulated p21. Interestingly,DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation,DHA directly reduced PGE2-induced cell proliferation in a dose-dependent manner. CONCLUSION:These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2.	Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang Cheng-Wei He Daniel C Baumgart Jing X Kang	2009	World Journal of Gastroenterology2009，15，9：	2
2	Experimental Validation of a New Ultrasound Method for the Simultaneous Assessment of Radial and Longitudinal Myocardial Deformation Independent of Insonation Angle显示文摘	Stian Langeland Jan D’hooge Patrick F. Wouters H Alex Leather Piet Claus Bart Bijnens George R. Sutherland	2005	Circulation2005，，14：	2
3	Analysis of sea spikes in radar sea clutter data显示文摘	Harm W Harm G Piet G Peter H	2006	IEEE Transactions on geoscience and remote sensing2006，44，4：	1
4	Predition of peak oxygen uptake in men using pulmonary and hemodynamic variables during exercise显示文摘	Bogaard H J H H Woltjer Anton R.J.Van Keimpema Piet E Postmus Peter M.J.M De Vries		0，，：	1
5	An accurateDC model for high-voltage lateral DMOS transistors suited for CAD显示文摘	Cleasen H R Zee Piet Ven Der	1986	IEEE Trans ED1986，33，12：	1
6	Extending the enterprise through multi - level supply control显示文摘	Piet van Vlist Jurgen J E M Hoppembrouwers Herman M H Hegge	1997	International Journal of Production Economics1997，53，：	1
7	On the galactosyl distribution of commercial galactomannans显示文摘	Schols Henk A De Jongh		Carbohydrate Polymers0，2052，4：	1
8	P-glycoprotein ABCB1: a major player in drug handling by mammals显示文摘	Borst Piet Schinkel Alfred H	2013	Journal of Clinical Investigation2013，，10：	1
9	State of the art of vehicular traffic flow modeling 显示文摘	SERGE P H PIET H L B	2001	Proceedings of the Institution of Mechanical Engineers: Part I: Journal of Systems and Control Engineering2001，215，4：	1
10	Focal Nodular Hyperplasia: Findings at state of the art MR imaging, US, CT and Pathologic Analysis显示文摘	S hahid M H ussain T T Piet er E	2004	Radiographics2004，7，24：	1
11	Synthesis,purification and characterization of cationic latices produced by the emulsion copolymerization of styrene with 3-(methacrylamidinopropyl)trimethylammonium chloride显示文摘	Van Streun K H Belt W J Piet P	1991	Eur Polym J1991，27，9：	1
12	Random Forests as a Tool for Ecohydrological Distribution Modelling显示文摘	Jan P Bernard D B Niko E C V Roeland S Sven D Piet D B Willy H	2007	Ecological Modelling2007，207，24：	1
13	Generic gas-kinet- ic traffic systems modeling with applications to vehicu- lar traffic flow 显示文摘	Serge P Hoogendoorn Piet H L Bovy	2001	Transportation Research Part B2001，35，：	1
14	Application of bacteriainvolved in the biological sulfur cycle for paper mill effluent purification 显示文摘	Albert J H J Piet N L L Alfons J M S	2009	Science of the Total Environment2009，407，：	1
15	Prognosis value of mitotic counts axillary node negative breast cancer patients with predominantly well differentiated tumors显示文摘	Piets WE Bellot FE Struikmans H	2005	Eur J Surg Oncol2005，31，：	1
16	The Effect of Roads and Traffic on Hedgenhog (Erinaceus Europaeus) Populations 显示文摘	Marcel P H Piet J M B	2000	Biological Conservation2000，95，：	1
17	Variable message signs and radio traffic information:an integrated empirical analysis of driver's route choice behavior 显示文摘	Emmerink Richard H M Nukamp Peter Rietveld Piet	1996	Transportation Research1996，30，2：	1
18	Variable message signs and radio traffic information:an integrated empirical analysis of drivers' route choice behavior显示文摘	Emmerink Richard H M Nijkamp Peter Rietveld Piet	1996	Transportation Research:Part A1996，30，2：	1
19	Purification and characterization of a sulfite: cytochrome c oxidoreductase from Thiobacinus acidophilus显示文摘	Goverdus A H de Jong Jane A Tang Piet Bos	2000	Journal of molecular catalysis B : Enzymatic2000，8，：	1
20	Resource partitioning along three niche dimensions in a size-structured tropical fish assemblage 显示文摘	PIET G J PET J S GURUGE W A H P	1999	Call J Fish Aquat Sci1999，56，7：	1

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