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153篇 您的检索式：作者名="PIETERS P"

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	题名	作者	年代	出处	被引量
1	ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease.	Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde	2014	World Journal of Gastroenterology2014，20，10：	2
2	The p rog-nostic significance of membrane transport2associated multidrug resistance (MDR) proteins in leukenia 显示文摘	Van der Heuvel-EibrinkM M Sonneveld P Pieters R	2000	Int J Clin Pharmacol Ther2000，38，3：	1
3	The N2myc paradox:N2myc overexpression in neurblastoma is associated wit h sensi2tivity as well as resistance to apoptosis显示文摘	Nosel M M Pieters R Voute P A	2003	Cancer Lett2003，197，12：	1
4	Fally acids of Opuntia engetmannnii显示文摘	PIETERS E P	1992	Phylochemistry1992，，8：	1
5	Partnership for sustainable leprosy control beyond 2005 显示文摘	Pieter F Vijaykumar P	2005	Lepr Rev2005，76，3：	1
6	Recyclable Au, Agand Au-Ag nanocolloids for the chemoselective hydrogenation of t, 13-unsaturated aldehydes and ketones to allylic alcohols显示文摘	PASCAL G N M PIETER V YE X P	2009	ApplCatalA: Genera2009，355，12：	1
7	Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘	Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager	2006	Lancet Oncology2006，，9：	1
8	Myeloid antigen coexpression in childhood acute lymphoblastic leukemia; relationship with in ritre drug resistance显示文摘	Den Boer ML kapaun P Pieters R	1999	Br J Haematol1999，105，4：	1
9	A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised triM显示文摘	Pieters R Sehrappe M De Lorenzo P	2007	Lancet2007，370，9583：	1
10	Chip-Package Codesign of a Low-Power 5-GHz RF Front End 显示文摘	Donnay S Pieters P Vaesen K	2000	Proceedings of the IEEE2000，88，10：	1
11	L-Asparaginase treatment in acute lymphoblastic leukemia显示文摘	PIETERS R HUNGER S P BOOS J	2011	Cancer2011，117，2：	1
12	Emergence delirium and pos- toperative pain in children undergoing adenotansineetomy : a comparison of propofol vs sevoflurane, anesthesia 显示文摘	Pieters BJ Penn E Nicklaus P	2010	Paediatr Anaesth2010，20，10：	1
13	Emergence delirium and postoperative pain in children undergoing adenotonsillectomy:a comparison of propofol vs sevoflurane anesthesia显示文摘	Pieters BJ Penn E Nicklaus P	2010	Paediatr Anaesth2010，20，10：	1
14	Emergence delirium and postop- erative pain in children undergoing adenotonsillectomy:a comparison of propofol VS sevoflurane anesthesia显示文摘	Pieters BJ Penn E Nicklaus P	2010	Paediatr Anaesth2010，20，10：	1
15	A treatment proto- col for infants younger than 1 year with acute lymphoblastic leu- kaemia (Interfant-99): an observational study and a muIticen- tre randomized trial 显示文摘	Pieters R Schrappe M De Lorenzo P	2007	Lancet2007，370，：	1
16	L-asparaginase treatment in acute lymphoblastic leukemia:a focus on Erwinia asparaginase显示文摘	Pieters R Hunger S P Boos J	2011	Cancer2011，117，2：	1
17	The N-myc paradox:Nmyc overexpression in neuroblastoma is associated with sensitivity as well as resistance to apoptosis显示文摘	Nosel M M Pieters R Voute P A	2003	Cancer Lett2003，197，12：	1
18	A treatment protocol for infants younger than 1 year with acute lymphoblastic leukemia ( interfant - 99 ) : An observational study and a multieentre randomised trial 显示文摘	Pieters R Sehrappe M de Lorenzo P	2007	Lancet2007，370，9583：	1
19	Emergence delirium and postoperative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia显示文摘	Pieters BJ Penn E Nicklaus P	2010	Paediatr Anaesth2010，20，10：	1
20	A singular perturbation problem with boundary and turning point resonance显示文摘	Pieter P N	1988	Applied Math-ematics Letters1988，1，1：	1

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