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| 1 | Crohn's disease of esophagus,stomach and duodenum显示文摘Crohn's disease with involvement of the esophagus, stomach and duodenum has a prevalence of 0.5% to 4% in symptomatic adult patients, but some studies have shown that these results may be underestimated, since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients, as it is in the pediatric population. In general, involvement of the upper gastrointestinal tract in Crohn's disease occurs concomitantly with involvement of the lower gastrointestinal tract. The diagnosis depends on clinical,endoscopic, histological and radiological evaluation. The presence of aphthoid ulcers, longitudinal ulcers, bamboo-joint-like appearance, stenoses and fistulas are endoscopic findings suggestive of the disease, and it is important to exclude the presence of Helicobacter pylori infection. The primary histological findings,which facilitate the diagnosis, are the presence of a chronic inflammatory process with a predominance of lymphoplasmacytic cells and active focal gastritis. The presence of epithelioid granuloma, although less frequent, is highly suggestive of the disease in the absence of chronic granulomatous disease. Treatment should include the use of proton pump inhibitors associated with corticosteroids,immunomodulators and biological therapy according to the severity of the disease. | Andréa Maia Pimentel Raquel Rocha Genoile Oliveira Santana | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，2： | 9 |
| 2 | The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness:an observational cohort study显示文摘 | SALCICCIOLI J D MARSHALL D C PIMENTEL M A | 2015 | Crit Care2015，19，： | 1 |
| 3 | Sequential changes in renal expression of rennin angiotensin system genes in acute unilate-ral ureteral obstruction显示文摘 | Pimentel JI Jr Montero A Wang S | 1995 | Kidney Int1995，48，4： | 1 |
| 4 | Environment and economic effects of reducing pesticide use in agriculture显示文摘 | Pimentel D McLaughlin L Zeep A | 1993 | Agriculture Ecosystems and Environment1993，46，： | 1 |
| 5 | Se-quence and function of lysosomal and digestive cathepsin D-likeproteinases of Musca domestica midgut显示文摘 | PADILHA M H PIMENTEL A C RIBEIRO A F | 2009 | Insect Biochem MolBiol2009，39，11： | 1 |
| 6 | Somatotrophic and corticotrophic function outcome after transesphenoidal surgery in patients with sellar tumors and pre-operative endocrine deficits显示文摘 | Salgado LR Cukiert A | 1997 | Arq Neuropsiquiatr1997，55，3： | 1 |
| 7 | Phosphine resistance, respiration rate and witness consequences in stored-product insects显示文摘 | PIMENTEL M A G FARONI L R D A TOTOLA M R | 2007 | Pest Manage- ment Science2007，63，9： | 1 |
| 8 | The influence of weathering conditions on the properties of poly( vinyl chloride) for outdoor applications:An analytical study using surface analysis techniques 显示文摘 | L E Pimentel Real A M Ferraria A M Botelho do Rego | 2007 | Polymer Testing2007，26，： | 1 |
| 9 | Predictive monitoring of mobile patients by combining clinical observations with data from wearable sensor显示文摘 | CLIFTON L CLIFTON D A PIMENTEL M A | 2014 | IEEE Journal of Biomedical and Health Informatics2014，18，3： | 1 |
| 10 | Differences in growth and water relations among Phaseol us vulgaris cultivars in response to induced drought stress显示文摘 | Fornca M G C Thi A T P Pimentel C | 2000 | Environmental and experimental botany2000，43，： | 1 |
| 11 | Environmental and economic effects of reducing pesticide use in agriculture显示文摘 | Pimentel D McLaughlin L Zepp A | 1993 | Ag- ric Ecosyst Environ1993，46，1： | 1 |
| 12 | Electromagnetic Stimulation Combined with Aloe vera Increases Collagen Reorganization in Burn Repair显示文摘 | Sofia Poletti Leticia D. Lucke Fernanda O Bortolazzo Renata M. Acunha Marcos G. Mattos Femanda OG. Gaspi Thiago A. M. Andrade Maria Esmeria C. Amaral Andrea A .Aro Edson R Pimentel Marcelo AM. Esquisatto Fernanda A. S. Mendonga Glaucia M. T. Santos | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
| 13 | Identification of novel transcripts in annotated genomes using RNA-Seq 显示文摘 | Roberts A Pimentel H Trapnell C | 2011 | Bioinformatics2011，27，17： | 1 |
| 14 | Rifaximin therapy for patients with irritable bowel syndrome without consti pation显示文摘 | Pimentel M Lembo A Chey WD | 2011 | N Engl J Med2011，64，1： | 1 |
| 15 | Rifaximin therapy for patients with irritable bowel syndrome without constipation显示文摘 | Pimentel M Lembo A Chey WD | 2011 | N Engl J Med2011，364，1： | 1 |
| 16 | Sequential changes in renal expression of renin angiotension system genes in acute unilateral ureteral obstruction显示文摘 | Pimentel JL Jr Montero A Wang S | 1995 | Kindey Int1995，48，4： | 1 |
| 17 | Endoglin and Alk5 regulate epithelial - mesenchymal transformation during cardiac valve formation 显示文摘 | MERCADO- PIMENTEL M E HUBBARD A D RUNYAN R B | 2007 | Dev Biol2007，304，1： | 1 |
| 18 | Excision and Redraping Skin and Orbicularis Oculi Muscle Separately during Transcutaneous Lower Eyelid Blepharoplasty显示文摘 | Haefliger I O Pimentel de Figueiredo A R | 2015 | Klin Monbl Augenheilkd2015，232，4： | 1 |
| 19 | Production of an Extracellular Polysaccharide with Emulsifier Properties by Penicillium citrinum 显示文摘 | CAMARGO-DE-MORAIS M M RAMOS S A F PIMENTEL M C B | 2003 | World J Microbiol &Biotechnol2003，19，2： | 1 |
| 20 | Wide-bandgap high-mobility ZnO thin-film transistors produced at room temperature 显示文摘 | Fortunato E Barquinha P Pimentel A | 2004 | Appl Phys Lett2004，85，13： | 1 |
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