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| 1 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Predictors of tuberculin reactivity among prospective Vietnamese migrants: the effect of smoking显示文摘 | Plant AJ Watkins RE Gushulak B O'Rourke T Jones W Streeton J Sang D | 2002 | Epidemiol Infect2002，128，1： | 1 |
| 3 | Evaluation of surface compo- nents of Brucella ovis as antigens for the detection of preeipitin antibody in serums from artificially exposed rams显示文摘 | Chin J C Plant J W Claxton P D | 1983 | Aust Vet J1983，60，： | 1 |
| 4 | AIDS-related experience, knowledge, attitudes and beliefs amongst nurses in area with a high rate of HIV infection显示文摘 | Plant M L Foster J | 1993 | Journal of Advanced Nursing1993，18，： | 1 |
| 5 | p53 and c-erbB-2 as makers of resistance to adjuvant chemotherapy in breast cancer显示文摘 | Tetu B Bfisson J Plante V | 1998 | Mod Pathol1998，11，9： | 1 |
| 6 | Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus 显示文摘 | Payne C J Ellis T M Plant S L | 1999 | Veterinary Microbiology1999，68，： | 1 |
| 7 | Statistics of branched fracture surfaces 显示文摘 | Bouchaud E Lapasset G Plants J | 1993 | Physical Review B1993，48，5： | 1 |
| 8 | 查看详情显示文摘 | Keller W C Plant W J | | 0，，： | 1 |
| 9 | Intranasat Immunization with gonoeoecal outer membrane preparations reduces the duration of vaginal colonization of mice by Neisseria gonorrhoeae 显示文摘 | Plante M Jerse A Hamel J | 2000 | Infect Dis2000，82，3： | 1 |
| 10 | The detection of the big liver and spleen agent in infected tissues via intravenous chick embryo inoculation 显示文摘 | Payne C J Plant S L Ellis T M | 1993 | Avian Pathology1993，22，： | 1 |
| 11 | Corner detection for chain coded curves 显示文摘 | Koplowitz J Plante S | 1995 | Pattern Recognition1995，28，6： | 1 |
| 12 | Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia:effects on rubrospinal tract regeneration, lesion size and functional recovery after implantation in the injured rat spinal cord显示文摘 | Ruitenberg M J Plant GW Hamers FP | 2003 | Neurosci2003，23，18： | 1 |
| 13 | Precipitation of calcite in the presence of inorganic phosphate显示文摘 | Plant L J House W A | 2002 | Colloids and Surfaces A : Physicochemical and Engineering Aspects2002，203，： | 1 |
| 14 | G Protein-cou- pled estrogen receptor (GPER) expression in normal and ab- normal endometrium显示文摘 | Plante B J Lessey B A Taylor R N | 2012 | Reprod Sci2012，19，7： | 1 |
| 15 | Large-scale failure modes of dielectric elastomer actuators显示文摘 | PLANTE J S DUBOWSKY S | | International Journal of Solids and Structures0，3，： | 1 |
| 16 | Numerical modeling of the propagation environment in the atmospheric boundary layer over the Persian Gulf显示文摘 | ATKINSON B W LI J G PLANT R S | 2001 | Journal of Applied Meteorology2001，40，3： | 1 |
| 17 | A qualitative simulation model for cotton growth and development显示文摘 | PLANT R E Kerby T A Zelinski L J | 1998 | Conputer and Electronics in Agriculture1998，20，16： | 1 |
| 18 | Lymph node metastases in low-grade endometrial stromal sarcoma 显示文摘 | Riopel J Plante M Renaud MC | 2005 | Gynecol Oncol2005，96，： | 1 |
| 19 | A Kalman filter based tracking scheme with input estimation显示文摘 | Chan Y T Hu A G C Plant J B | 1979 | IEEE Trans on Aerospace Electronic System1979，15，2： | 1 |
| 20 | Simple vaginal trachelectomy in early-stage low-risk cervical cancer:a pilot study of 16 cases and review of the literature显示文摘 | Plante M Gregoire J Renaud MC | 2013 | Int J Gynecol Cancer2013，23，5： | 1 |
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