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| 1 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 2 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 3 | Oxygen in the Earth' s core: A first-principles study显示文摘 | Alfe D Price G D Gillan M J | 1999 | Physics of Earth and Planetary Interior1999，110，： | 1 |
| 4 | Architects' perspectives on construction waste reduction by design显示文摘 | Osmani M Glass J Price A D F | | 0，，07： | 1 |
| 5 | Zinc alpha-2-gly- coprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer 显示文摘 | Hale L P Price D T Sanchez L M | 2001 | Clin Cancer Res2001，7，4： | 1 |
| 6 | An essential role of NF kappa B in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia 显示文摘 | Maulik N Sato M Price B D | 1998 | Febs Lett1998，429，3： | 1 |
| 7 | The effect of welding parameters on the corrosion behaviour of friction stir welded AA2024-T351 显示文摘 | JARIYABOON M DAVENPORT A J AMBAT R CONNOLLY B J WILLIAMS S W PRICE D A | 2007 | Corrosion Science2007，49，2： | 1 |
| 8 | Earnings conference calls and stock returns: The incremental informativeness of textual tone显示文摘 | Price S M Doran J S Peterson D R | 2012 | Journal of Banking & Finance2012，36，4： | 1 |
| 9 | Modified extraction 2-thiobarbituric acid method for measuring lipid oxidation inp?ultry显示文摘 | SALIH A M SMITH D M PRICE J F | 1987 | Poultry Science1987，66，9： | 1 |
| 10 | The role of carbonic anhydrase in hotosynthesis 显示文摘 | Badger M R Price G D | 1994 | Annual Review of Plant1994，45，： | 1 |
| 11 | Alterations in working memory as a function of leukoaraiosis in dementia 显示文摘 | Lamar M Price CC Libon D J | 2007 | Neuropsychologia2007，45，2： | 1 |
| 12 | Human cyclophilin B: A second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence显示文摘 | Price E R Zydowsky L D Jin M J | 1991 | Biochemistry1991，88，5： | 1 |
| 13 | Insulin- like growth factor- l (IGP- I ) regulates IGFBP-3 and IGFBP- 4 by multiple mechanisms in A549 human adenocarcinoma cells显示文摘 | PRICE W A MOATSTAATS B M STILES A D | 1995 | American Journal of Respiratory Cell and Molecular Bio-logy1995，13，4： | 1 |
| 14 | EPOS Primary Care Guidelines: European Position Paper on the Primary Care Diagnosis and Manage- ment of Rhinosinusitis and Nasal Polyps 2007-a summary 显示文摘 | Thomas M Yawn B Price D | 2008 | Prim Care Respir J2008，17，2： | 1 |
| 15 | An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia显示文摘 | Maulik N Sato M Price B D | 1998 | FEBS Lett1998，429，3： | 1 |
| 16 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 17 | Aeolian-fluvial inter- action and climate change:source-bordering dune development over the past- 100 ka on Cooper Creek, central Australia显示文摘 | Maroulis J C Nanson G C Price D M | 2007 | Quater- nary Science Reviews2007，26，3： | 1 |
| 18 | Cystatin C:An improved estimator of glomerular filtration rate显示文摘 | Laterza D F Price C P Scott M G | 2002 | Clin Chem2002，48，5： | 1 |
| 19 | The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain显示文摘 | Lazzaro D Price M de Felice M | 1991 | Development1991，113，： | 1 |
| 20 | Characterisation of carbon dioxide and bicarbonate transport during steady-state photosynthesis in the marine cyanobacterium Synechococcus strain PCC7002显示文摘 | Sültemeyer D Price G D Yu J W Badger M R | 1995 | Planta1995，197，： | 1 |
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