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| 1 | NOD2/CARD15 , ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease显示文摘AIM: To assess whether the polymorphisms of NOD2/ CARD15 , autophagy-related 16-like 1 (ATG16L1 ), and interleukin-23 receptor (IL23R ) genes play a more critical role in the susceptibility of childhood-onset than in adult-onset Crohn’s disease (CD). METHODS: Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 ; rs2241880 A/G of ATG16L1 , and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals. Analysis of polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 genotyping was performed by allele specific polymerase chain reaction (PCR) or by PCR-restriction fragment length polymor-phism analysis. The polymorphisms rs2241880 A/G of the ATG16L1 , and rs11209026 (R381Q) of the IL23R gene in the children’s cohort were genotyped by PCR and melting curve analysis whereas adult group genotyping was performed using the Affymetrix Genome-Wide Human SNP Array 5.0 (500K). RESULTS: The 3020insC allele in NOD2/CARD15 was significantly higher in childhood than in adult-onset CD (P = 0.0067). Association with at least 1 NOD2/CARD15 variant was specific for ileal disease (with or without co- lonic involvement). Even if the frequency of G allele of the rs2241880 ATG16L1 polymorphism was increased in both paediatric and adult CD patients compared to con- trols (P = 0.017 and P = 0.001, respectively), no difference was observed between the childhood and the adult cohort. The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort. The presence of the rs2241880 ATG16L1 and rs11209026 IL23R polymorphisms did not influence disease phenotype. CONCLUSION: Polymorphism 3020insC in NOD2/ CARD15 occurs statistically significantly more often in patients with childhood-onset CD than in patients with adult-onset CD. The ATG16L1 and IL23R variants are associated with susceptibility to CD, but not earlyonset disease. | Maria Gazouli Ioanna Pachoula Ioanna Panayotou Gerassimos Mantzaris George Chrousos Nicholas P Anagnou Eleftheria Roma-Giannikou | 2010 | World Journal of Gastroenterology2010，16，14： | 7 |
| 2 | PARALLEL AUXILIARY SPACE AMG FOR H(curl) PROBLEMS显示文摘在我们考察的这份报纸,很多个辅助空格基于 preconditioners 因为第二与最低顺序 N 慴敧订明确、半明确的麦克斯韦问题 discretized 吗? | Tzanio V.Kolev Panayot S.Vassilevski | 2009 | Journal of Computational Mathematics2009，27，5： | 3 |
| 3 | Phosphoinositide 3-kinase:a conserved family of signal transduces显示文摘 | LEEVERS S J PANAYOTOU G | 1997 | Trends Biochem Sci1997，22，7： | 1 |
| 4 | Compensation for 'Meaningful Participation' in Climate Change Control: A Modest Proposal and Empirical Analysis 显示文摘 | Panayotou T Sachs J D Zwane A P | 2002 | Journal of Environmental Economics and Management2002，43，： | 1 |
| 5 | Economic Growth and the Environment显示文摘 | Panayotou T | 2003 | Economic Survey of Europe2003，，2： | 1 |
| 6 | Phosphoinositide 3-kinases: a conserved family of signal transducers 显示文摘 | Vanhaesebroeck B Leevers S J Panayotou G | 1997 | Trends Biochem Sci1997，22，7： | 1 |
| 7 | Demystifying the environmental Kuznets Curve : Turning a black box into a policy tool显示文摘 | Panayotou T | 1997 | Environmental and Development Economics1997，2，4： | 1 |
| 8 | PI3 kinase is a dual specificity enzyme: autoregulation by an intrinsic protein- serine kinase activity显示文摘 | Dhand R Hiles I Panayotou G | | 0，，03： | 1 |
| 9 | Economic Growth and the Environment 显示文摘 | PANAYOTOU T | 2003 | Economic Smwey of Europe(S00708712)2003，，2： | 1 |
| 10 | Demystifying the environmental Kuznets curve: turning a black box into a policy tool 显示文摘 | Panayotou T | 1997 | Environment and Development Economics1997，2，4： | 1 |
| 11 | Demystifying the environmental Kuznets curve: turning a black box into a policy tool 显示文摘 | Panayotou T | 1997 | Environment Development Economics1997，2，46： | 1 |
| 12 | Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-lalpha显示文摘 | Mylonis I Chachami G Samiotaki M Panayotou G Paraskeva E Kalousi A | 2006 | J Biol Chem2006，281，33： | 1 |
| 13 | Demystifying the environmental Kuznets curve: turning a black box into a policy tool显示文摘 | PANAYOTOU T | 1997 | Environment and Devel- opment Economics1997，2，4： | 1 |
| 14 | Efficient information theoretic strategies for classifier combination,feature extraction and performance evaluation in improving false positives and false negatives for spam e-mail filtering显示文摘 | ZORKADIS V KARRAS DA PANAYOTOU M | 2005 | Neural Networks2005，18，56： | 1 |
| 15 | Introduction to the Environmental Kuznets Curve Special Issue 显示文摘 | Panayotou | 1997 | Environment and Development Economics1997，，4： | 1 |
| 16 | (1997) 'Demystifying the envinmmental Kuznets cm've: turning a black box into a policy tool' Environmental and Development Economics 显示文摘 | Panayotou T | 1997 | 21997，4，： | 1 |
| 17 | Phosphoinositide 3-kinases: a conserved family of signal transducers 显示文摘 | Vanhaesebroeck B Leevers S J Panayotou G | 1997 | Trends Biochem Sci1997，22，7： | 1 |
| 18 | Copper (Ⅱ) interaction and complexation with 1-显示文摘 | Panayot R Bontchev Georgi Gochev | 1992 | Journal of Inorganic Biochemistry1992，46，1： | 1 |
| 19 | Phosphoinositide 3-Kinases:a Conserved Family of Signal Transducers 显示文摘 | Vanhaesebroeck B Leevers S J Panayotou G | 1997 | Trends Biochem Sci1997，22，： | 1 |
| 20 | Demystifying the environmental Kuznets curve:turning a black box into a policy tool显示文摘 | PANAYOTOU T | 1997 | Environment and Development Economies1997，，2： | 1 |
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