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| 1 | 慢性心力衰竭患者症状管理自我效能及其影响因素的调查研究显示文摘目的探查慢性心力衰竭(下称心衰)患者的症状管理自我效能水平及其影响因素。方法采取方便抽样,2013年1~6月对112例心衰住院患者进行问巷调查。共发放问卷112份,回收90份。问卷由一般人口学资料、疾病情况、社会支持量表和症状管理自我效能量表组成。结果心衰患者症状管理的自我效能平均得分为6.67分。高中及以上文化、家庭经济收入中等及以上、合并症数量少和曾受过健康指导的心衰患者具有更高的症状管理自我效能(F=8.332,R^2=0.282,P〈0.001)。在控制其他变量后,社会支持仍可增加回归模型对症状管理自我效能的预测力(△R^2=0.052,P=0.013)。结论慢性心衰患者症状管理的自我效能还有待提高;加强患者的社会支持,可能提高患者对症状管理的自我效能;合并症多、受教育程度低和家庭经济收入低的患者应给予重点关注。 | 尚刘文心 沈美芳 陈文瑶 Basanti Pandey 朱大乔 | 2014 | 中华护理杂志2014，49，6： | 114 |
| 2 | A review:On path planning strategies for navigation of mobile robot显示文摘This paper presents the rigorous study of mobile robot navigation techniques used so far.The step by step investigations of classical and reactive approaches are made here to understand the development of path planning strategies in various environmental conditions and to identify research gap.The classical approaches such as cell decomposition(CD),roadmap approach(RA),artificial potential field(APF);reactive approaches such as genetic algorithm(GA),fuzzy logic(FL),neural network(NN),firefly algorithm(FA),particle swarm optimization(PSO),ant colony optimization(ACO),bacterial foraging optimization(BFO),artificial bee colony(ABC),cuckoo search(CS),shuffled frog leaping algorithm(SFLA)and other miscellaneous algorithms(OMA)are considered for study.The navigation over static and dynamic condition is analyzed(for single and multiple robot systems)and it has been observed that the reactive approaches are more robust and perform well in all terrain when compared to classical approaches.It is also observed that the reactive approaches are used to improve the performance of the classical approaches as a hybrid algorithm.Hence,reactive approaches are more popular and widely used for path planning of mobile robot.The paper concludes with tabular data and charts comparing the frequency of individual navigational strategies which can be used for specific application in robotics. | B.K. Patle Ganesh Babu L Anish Pandey D.R.K. Parhi A. Jagadeesh | 2019 | Defence Technology(防务技术)2019，15，4： | 60 |
| 3 | Calcineurin-B-Like Protein CBL9 Interacts with Target Kinase CIPK3 in the Regulation of ABA Response in Seed Germination显示文摘钙在植物在许多发信号的小径作为第二个送信人起一个重要作用。calcineurin 象 B 一样蛋白质(CBL ) 代表在钙由与他们的交往的蛋白质 kinases (CIPK ) 交往发信号工作的植物钙绑定蛋白质的一个家庭。在我们的以前的学习,我们在骆驼毛的织物发信号为 CBL (CBL9 ) 之一和 CIPK (CIPK3 ) 之一报导了一个角色。这里,我们证明了 CBL9 和 CIPK3 身体上并且机能上地在调整骆驼毛的织物回答与对方一起交往。CBL9 和 CIPK3 蛋白质在酵母与对方一起交往了二混血儿的系统并且当在植物房间表示了时。双变异的 cbl9cipk3 显示出类似的过分敏感的反应到在单个异种(cbl9 或 cipk3 ) 观察了的骆驼毛的织物。CIPK3 的组成地活跃的形式遗传上补充了 cbl9 异种,显示 CIPK3 CBL9 下游地工作。把调查结果基于这些,我们为调整骆驼毛的织物回答在一样的小径一起结束那 CBL9 和 CIPK3 幕。 | Girdhar K. Pandey John J. Grant Yong Hwa Cheong Beom-Gi Kim Le Gong Li Sheng Luan | 2008 | Molecular Plant2008，1，2： | 44 |
| 4 | 基于倾向得分匹配法分析农业技术采用对农户收入的影响——以滇西南农户改良陆稻技术采用为例显示文摘【目的】考察改良陆稻技术采用对农户收入的影响,以促进农业技术的创新与进步。【方法】为解决传统方法分析农业技术效应时农户技术采用'自选择'而带来的因果干涉问题,引入非参数的倾向得分匹配法,利用滇西南山区8县16村2000年、2002年和2004年473个农户调查数据,评估改良陆稻技术采用对山区农户收入的效应。【结果】利用倾向得分匹配法分析,改良陆稻技术采用户的收入在2000年、2002年和2004年分别是非采用情况下的1.49、1.34和1.23倍。利用描述性统计分析方法,以上3个年份中技术采用户的收入分别是非采用户的1.79、1.49和1.27倍。【结论】改良陆稻技术的采用对农户的收入提高具有稳健的正向效应。在考察的年份里,技术采用的效应呈现递减趋势。与倾向得分匹配法相比,一般描述性统计分析会高估技术采用的效应。 | 陈玉萍 吴海涛 陶大云 Sushil Pandey 徐鹏 胡凤益 丁士军 王怀豫 冯璐 | 2010 | 中国农业科学2010，43，17： | 28 |
| 5 | CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis显示文摘钾是为在植物的很多个细胞的过程的主要宏营养素必需品之一。在土壤的低钾水平为庄稼生产代表一个限制因子。最近的研究识别了涉及钾获得的钾运输 ers,并且他们中的一些为在低钾条件下面的钾营养是批评的。然而,很少在涉及低钾发信号和回答的分子的部件上被理解。我们这里在 Arabidopsis 作为低钾反应的一个批评管理者报导 calcineurin 象 B 一样交往蛋白质的 proteinkinase (CIPK9 ) 的鉴定。CIPK9 基因对不能生活的压力条件应答,并且它的抄本由钾剥夺在根和射击是可诱导的。CIPK9 功能的混乱使变异的植物变为过分敏感到低钾媒介。进一步的分析显示那 K (+) 举起和内容没在变异的植物被影响,暗示在钾利用的规定的 CIPK9 或察觉到过程。 | Girdhar K Pandey Yong Hwa Cheongx Beom-Gi Kim John J Grant Legong Li Sheng Luan | 2007 | Cell Research2007，17，5： | 23 |
| 6 | Acclimation and Tolerance Strategies of Rice under Drought Stress显示文摘Rice(Oryza sativa L.) is an important food crop and requires larger amount of water throughout its life cycle as compared to other crops. Hence,water related stress cause severe threat to rice production. Drought is a major challenge limiting rice production. It affects rice at morphological(reduced germination,plant height,plant biomass,number of tillers,various root and leaf traits),physiological(reduced photosynthesis,transpiration,stomatal conductance,water use efficiency,relative water content,chlorophyll content,photosystem Ⅱ activity,membrane stability,carbon isotope discrimination and abscisic acid content),biochemical(accumulation of osmoprotectant like proline,sugars,polyamines and antioxidants) and molecular(altered expression of genes which encode transcription factors and defence related proteins) levels and thereby affects its yield. To facilitate the selection or development of drought tolerant rice varieties,a thorough understanding of the various mechanisms that govern the yield of rice under water stress condition is a prerequisite. Thus,this review is focused mainly on recent information about the effects of drought on rice,rice responses as well as adaptation mechanisms to drought stress. | Veena PANDEY Alok SHUKLA | 2015 | Rice science2015，22，4： | 23 |
| 7 | 颅内血管神经介入治疗的适应证美国心脏协会心血管放射学和介入委员会、卒中委员会、心血管外科和麻醉委员会、外周血管病跨学科委员会以及护理质量和转归研究跨学科委员会的联合学术声明显示文摘颅内血管内介入是一种使用微侵袭血管内技术治疗脑血管病的方法。该专业领域在过去10年里取得了巨大进展,而且随着该学科得到越来越多的临床认可,这种进步的速度还在加快。 | Philip M. Meyers H. Christian Schumacher Randall T. Higashida Stanley L. Barnwell Mark A. Creager Rishi Gupta Cameron G. McDougall Dilip K. Pandey David Sacks Lawrence R. Wechsler 乔梵(译) 刘建民(译) 洪波(译) | 2009 | 国际脑血管病杂志2009，17，10： | 16 |
| 8 | Targeted therapy of gastrointestinal stromal tumours显示文摘Gastrointestinal stromal tumours(GISTs) are mesen-chymal neoplasms originating in the gastrointestinal tract, usually in the stomach or the small intestine, and rarely elsewhere in the abdomen. The malignant potential of GISTs is variable ranging from small lesions with a benign behaviour to fatal sarcomas. The majo-rity of the tumours stain positively for the CD-117(KIT) and discovered on GIST-1(DOG-1 or anoctamin 1) expression, and they are characterized by the presence of a driver kinase-activating mutation in either KIT or platelet-derived growth factor receptor α. Although surgery is the primary modality of treatment, almost half of the patients have disease recurrence following surgery, which highlights the need for an effective adjuvant therapy. Traditionally, GISTs are considered chemotherapy and radiotherapy resistant. With the advent of targeted therapy(tyrosine kinase inhibitors), there has been a paradigm shift in the management of GISTs in the last decade. We present a comprehensive review of targeted therapy in the management of GISTs. | Ashish Jakhetiya Pankaj Kumar Garg Gaurav Prakash Jyoti Sharma Rambha Pandey Durgatosh Pandey | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 14 |
| 9 | Path planning in uncertain environment by using firefly algorithm显示文摘Autonomous mobile robot navigation is one of the most emerging areas of research by using swarm intelligence. Path planning and obstacle avoidance are most researched current topics like navigational challenges for mobile robot. The paper presents application and implementation of Firefly Algorithm(FA)for Mobile Robot Navigation(MRN) in uncertain environment. The uncertainty is defined over the changing environmental condition from static to dynamic. The attraction of one firefly towards the other firefly due to variation of their brightness is the key concept of the proposed study. The proposed controller efficiently explores the environment and improves the global search in less number of iterations and hence it can be easily implemented for real time obstacle avoidance especially for dynamic environment. It solves the challenges of navigation, minimizes the computational calculations, and avoids random moving of fireflies. The performance of proposed controller is better in terms of path optimality when compared to other intelligent navigational approaches. | B.K.Patle Anish Pandey A.Jagadeesh D.R.Parhi | 2018 | Defence Technology(防务技术)2018，14，6： | 14 |
| 10 | 高PM2.5地区呼吸系统疾病发病率流行病学调查显示文摘目的探讨高PM2.5地区居民呼吸系统疾病发病率情况。方法采取随机抽样方法,廊坊市区、呼和浩特市区常住居民共3564例填写呼吸系统流行病学调查表,统计并比较两地市区居民2008年1月1日至2016年12月30日呼吸系统疾病发病率、症状发生率。在廊坊市区被调查者中随机抽取200例填写2012—2016年每年度呼吸系统流行病学调查表,并统计年均PM2.5浓度,探讨呼吸系统疾病和PM2.5浓度的相关性。结果廊坊市年均PM2.5浓度、空气质量指数明显高于呼和浩特市区(P值均〈0.05)。廊坊市区居民鼻炎、鼻敏感、慢性咽炎、上呼吸道感染、鼻窦炎、支气管炎、支气管哮喘、慢性阻塞性肺疾病(COPD)、肺炎、呼吸系统肿瘤、间质性肺病发病率均高于呼和浩特市区居民(P值均〈0.05);廊坊市区居民咳嗽、咳痰、喘息气促、咽部不适、鼻塞、喉咙痛、喘鸣、呼吸困难发生率高于呼和浩特市区居民(P值均〈0.05)。PM2.5浓度与鼻炎、慢性咽炎、上呼吸道感染、支气管炎、支气管哮喘呈正相关(P值均≤0.05)。结论高PM2.5地区鼻炎、鼻敏感、慢性咽炎、上呼吸道感染、鼻窦炎、支气管炎、支气管哮喘、COPD、肺炎、呼吸系统肿瘤、间质性肺病的发病率较高;高PM2.5地区居民更易发生咳嗽、咳痰、喘息气促、咽部不适、鼻塞、喉咙痛、喘鸣、呼吸困难。 | 高菲 边毓尧 郭文有 修明文 刘永纯 陈光远 Nishant Raj Pandey | 2018 | 国际呼吸杂志2018，38，18： | 13 |
| 11 | Understanding the multifunctionality in Cu-doped BiVO_4 semiconductor photocatalyst显示文摘A visible light-induced, Cu-doped BiVO_4 photocatalyst was synthesized by a microwave hydrothermal method. The photocatalytic efficiency was investigated in the degradation of model water pollutants like Methylene Blue(dye) and ibuprofen(pharmaceuticals), as well as the inactivation of Escherichia coli(bacteria). The Cu-doped BiVO4 samples showed better efficiency than undoped BiVO_4, and the 1 wt.% Cu-doped BiVO_4 sample showed the best efficiency. The degradation of Methylene Blue reached 95%, while the degradation of ibuprofen reached 75%, and the inactivation of E. coli reached 85% in irradiation with visible light. The appearance of additional absorption band shoulders and widening of the optical absorption in the visible range makes the prepared powder an efficient visible light-driven photocatalyst. Moreover, the formation of an in-gap energy state just above the valance band as determined by density functional theory(DFT) first principle calculation, facilitates the wider optical absorption range of the doped system. Similarly, this in-gap energy state also acts as an electron trap, which is favorable for the efficient separation and photoexcited charge carriers' transfer process. The formation of oxygen vacancies due to doping also improved the separation of the charge carrier, which promoted the trapping of electrons and inhibited electron hole recombination, thus increasing the photocatalytic activity. No decrease in the efficiency of the 1 wt.% Cu-doped BiVO_4 photocatalyst in the degradation of ibuprofen over three consecutive cycles revealed the stability of the photocatalyst towards photocorrosion. These findings highlight the multifunctional applications of Cu-doped BiVO_4 in wastewater containing multiple pollutants. | Chhabilal Regmi Yuwaraj K.Kshetri Ramesh Prasad PANDey Tae-Ho Kim Gobinda Gyawali Soo Wohn Lee | 2019 | Journal of Environmental Sciences2019，31，1： | 12 |
| 12 | Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia:a molecular docking study exploring possible neuroprotection显示文摘The main pathophysiology of cerebral ischemia is the structural alteration in the neurovascular unit, coinciding with neurovascular matrix degradation. Resveratrol has been reported to be one of the most potent chemopreventive agents that can inhibit cellular processes associated with ischemic stroke. Matrix metalloproteinases(MMPs) has been considered as a potential drug target for the treatment of cerebral ischemia. To explore this, we tried to investigate the interaction of resveratrol with MMPs through molecular docking studies. At 30 minutes before and 2 hours after cerebral ischemia/reperfusion induced by occlusion of the middle cerebral artery, 40 mg/kg resveratrol was intraperitoneally administered. After resveratrol administration, neurological function and brain edema were significantly alleviated, cerebral infarct volume was significantly reduced, and nitrite and malondialdehyde levels in the cortical and striatal regions were significantly decreased. The molecular docking study of resveratrol and MMPs revealed that resveratrol occupied the active site of MMP-2 and MMP-9. The binding energy of the complexes was –37.848672 k J/mol and –36.6345 k J/mol for MMP-2 and MMP-9, respectively. In case of MMP-2, Leu 164, Ala 165 and Thr 227 were engaged in H-Bonding with resveratrol and in case of MMP-9, H-bonding was found with Glu 402, Ala 417 and Arg 424 residues. These findings collectively reveal that resveratrol exhibits neuroprotective effects on cerebral ischemia through inhibiting MMP-2 and MMP-9 activity. | Anand Kumar Pandey Pallab Bhattacharya Swet Chand Shukla Sudip Paul Ranjana Patnaik | 2015 | Neural Regeneration Research2015，10，4： | 12 |
| 13 | Optimum path planning of mobile robot in unknown static and dynamic environments using Fuzzy-Wind Driven Optimization algorithm显示文摘This article introduces a singleton type-1 fuzzy logic system(T1-SFLS) controller and Fuzzy-WDO hybrid for the autonomous mobile robot navigation and collision avoidance in an unknown static and dynamic environment. The WDO(Wind Driven Optimization) algorithm is used to optimize and tune the input/output membership function parameters of the fuzzy controller. The WDO algorithm is working based on the atmospheric motion of infinitesimal small air parcels navigates over an N-dimensional search domain. The performance of this proposed technique has compared through many computer simulations and real-time experiments by using Khepera-Ⅲ mobile robot. As compared to the T1-SFLS controller the Fuzzy-WDO algorithm is found good agreement for mobile robot navigation. | Anish Pandey Dayal R.Parhi | 2017 | Defence Technology(防务技术)2017，13，1： | 12 |
| 14 | A numerical method for structural uncertainty response computation显示文摘A novel numerical procedure,which realizes the stochastic analysis with dimensional reduction integration(DRI) ,C-type Gram-Charlier(CGC) series,and finite element(FE) model,is proposed to assess the probability distribution of structural per-formance. From the relationship between the weighting function of orthogonal polynomial and probability density function(PDF) of random variable,the numerical integration formulas are derived for moment computation. Then,distribution of structural uncertainty response can be approximated by the CGC series with the calculated moments. Three engineering appli-cations for the distribution of,the maximum displacement of a ten-bar planer truss,natural frequency of an auto frame,and Von-Mises stress of a bending pipe,are employed to illustrate the computational efficiency and accuracy of the proposed methodology. As compared with plain Monte Carlo simulation(MCS) ,the method can obtain the accurate distribution of structural performance. Especially at the tail region of cumulative distribution function(CDF) ,results have shown the satisfy-ing estimators for small probabilities,say,P10-4,10-3]. That implies the method could be trusted for structural failure prob-ability prediction. As the computational efficiency is concerned,the procedure could save more than two orders of computational resources as compared with the direct numerical integration(NI) and MCS. Furthermore,realization of the procedure does not require computing the performance gradient or Hessian matrix with respect to random variables,or reshaping the finite element matrix as other stochastic finite element(SFE) codes. Therefore,it should be an efficient and reliable routine for uncertainty structural analysis. | ZHANG XuFang PANDEY Mahesh D. ZHANG YiMin | 2011 | Science China(Technological Sciences)2011，54，12： | 11 |
| 15 | Frozen shoulder-A prospective randomized clinical trial显示文摘AIM To compare the results of arthroscopic capsular release with intra-articular steroid injections in patients of frozen shoulder.METHODS Fifty-six patients with frozen shoulder were randomised to one of two treatment groups: Group 1, complete 360 degree arthroscopic capsular release and group 2, intra-articular corticosteroid injection(40 mg methyl prednisolone acetate). Both groups were put on active and passive range of motion exercises following the intervention. The outcome parameters were visual analogue scale(VAS) score for pain, range of motion and Constant score which were measured at baseline, 4, 8, 12, 16 and 20 wk after intervention.RESULTS All the parameters improved in both the groups. The mean VAS score improved significantly more in the group 1 as compared to group 2 at 8 wk. This greater improvement was maintained at 20 wk with P value of 0.007 at 8 wk, 0.006 at 12 wk, 0.006 at 16 wk and 0.019 at 20 wk. The Constant score showed a more significant improvement in group 1 compared to group 2 at 4 wk, which was again maintained at 20 wk with P value of 0.01 at 4, 8, 12 and 16 wk. The gain in abduction movement was statistically significantly more in arthroscopy group with P value of 0.001 at 4, 8, 12, 16 wk and 0.005 at 20 wk. The gain in external rotation was statistically significantly more in arthroscopy group with P value of 0.007 at 4 wk, 0.001 at 8, 12, and 16 wk and 0.003 at 20 wk. There was no statistically significant difference in extension and internal rotation between the two groups at any time. CONCLUSION Arthroscopic capsular release provides subjective and objective improvement earlier than intra-articular steroid injection. | Rudra Narayan Mukherjee R M Pandey Hira Lal Nag Ravi Mittal | 2017 | World Journal of Orthopedics2017，8，5： | 11 |
| 16 | 响应面法优化姬松茸液体发酵培养基中红糖和酵母膏浓度显示文摘运用响应面分析法优化姬松茸液体发酵培养基中红糖和酵母膏浓度。结果表明,红糖浓度为20.24g/L、酵母膏浓度为2.055g/L时,菌丝体生物量最高,达2.279g/L;红糖浓度为20.8g/L、酵母膏浓度为2.23g/L时,胞外多糖产量最高,达0.749g/L。 | 范雷法 潘慧娟 Soccol CR Pandey A | 2005 | 食用菌学报2005，12，3： | 11 |
| 17 | AA5083铝合金的搅拌摩擦焊接工艺参数对搅拌头受力和热输入的影响(英文)显示文摘采用系统实验设计方法研究AA5083铝合金搅拌摩擦焊接工艺参数对搅拌头受力和热量输入的影响,得到了用来设计搅拌摩擦焊搅拌头和焊机的经验模型。当采用计算机来控制搅拌摩擦焊接时,这些模型可用来确定AA5083这类铝合金的摩擦焊接工艺参数、编制焊接程序及工艺参数控制。结果表明:影响轴向力和热量输入的重要参数是搅拌头转速、焊接速度和搅拌头轴肩直径,而影响纵向应力的重要参数是焊接速度和探头直径。 | Rajneesh KUMAR Kanwer SINGH Sunil PANDEY | 2012 | Transactions of Nonferrous Metals Society of China2012，22，2： | 10 |
| 18 | Monitoring the impact of climate change and human activities on grassland vegetation dynamics in the northeastern Qinghai-Tibet Plateau of China during 2000–2015显示文摘Climate change and human activities can influence vegetation net primary productivity(NPP), a key component of natural ecosystems. The Qinghai-Tibet Plateau of China, in spite of its significant natural and cultural values, is one of the most susceptible regions to climate change and human disturbances in the world. To assess the impact of climate change and human activities on vegetation dynamics in the grassland ecosystems of the northeastern Qinghai-Tibet Plateau, we applied a time-series trend analysis to normalized difference vegetation index(NDVI) datasets from 2000 to 2015 and compared these spatiotemporal variations with trends in climatic variables over the same time period. The constrained ordination approach(redundancy analysis) was used to determine which climatic variables or human-related factors mostly influenced the variation of NDVI. Furthermore, in order to determine whether current conservation measures and programs are effective in ecological protection and reconstruction, we divided the northeastern Qinghai-Tibet Plateau into two parts: the Three-River Headwater conservation area(TRH zone) in the south and the non-conservation area(NTRH zone) in the north. The results indicated an overall(73.32%) increasing trend of vegetation NPP in grasslands throughout the study area. During the period 2000–2015, NDVI in the TRH and NTRH zones increased at the rates of 0.0015/a and 0.0020/a, respectively. Specifically, precipitation accounted for 9.2% of the total variation in NDVI, while temperature accounted for 13.4%. In addition, variation in vegetation NPP of grasslands responded not only to long-and short-term changes in climate, as conceptualized in non-equilibrium theory, but also to the impact of human activities and their associated perturbations. The redundancy analysis successfully separated the relative contributions of climate change and human activities, of which village population and agricultural gross domestic product were the two most important contributors to the NDVI changes, explaining 17.8% and 17.1% of the total variation of NDVI(with the total contribution >30.0%), respectively. The total contribution percentages of climate change and human activities to the NDVI variation were 27.5% and 34.9%, respectively, in the northeastern Qinghai-Tibet Plateau. Finally, our study shows that the grassland restoration in the study area was enhanced by protection measures and programs in the TRH zone, which explained 7.6% of the total variation in NDVI. | XIONG Qinli XIAO Yang Marwa Waseem A HALMY Mohammed A DAKHIL LIANG Pinghan LIU Chenggang ZHANG Lin Bikram PANDEY PAN Kaiwen Sameh B EL KAFRAWAY CHEN Jun | 2019 | Journal of Arid Land2019，11，5： | 10 |
| 19 | 傅里叶变换用于地下电缆故障检测(英文)显示文摘An analysis of underground power cables is performed using Fourier analysis with the objective of detecting fault and average life of the cables.Three types of cables are used in this experiment:a normal cable,a shorted cable, and a cable with holes.The impedance in each case is computed and Fourier transformation is applied so that the resulting impedance magnitude and impedance phase can be examined in the frequency domain.Various windowing techniques are applied to the experimental data to eliminate any interference.Fourier analysis is then applied to the impedance data calculated from both the sending end voltage and differential voltage.This analysis reveals differences in the frequency response of the three different types of a cable and can eventually be used as a measure for fault detection. Preliminary results reveal the differences in the frequency response.Accordingly,Fourier type methods can be effectively used as low cost and viable solutions to identify and detect faults in underground cables. | Abhishek Pandey Nicolas H.Younan | 2011 | 高电压技术2011，37，11： | 9 |
| 20 | Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study显示文摘AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) patients.METHODS This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also analysed.RESULTS A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Both treaments showed acceptable safety profiles. The telbivudine arm showed e GFR improvement unlike the tenofovir arm.CONCLUSION Efficacy was shown for both telbivudine-roadmap and tenofovir-roadmap regimens in HBe Ag-negative CHB patients over 156 wk. Telbivudine arm was associated with renal improvement. | Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra Priti Pandey Kamal Hamed | 2016 | World Journal of Hepatology2016，8，32： | 9 |
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