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| 1 | Albuminuria as a marker of arterial stiffness in chronic kidney disease patients显示文摘AIM:To access the association between albuminuria levels and arterial stiffness in non-diabetic patients with hypertension and chronic kidney disease(CKD) stages 1-2,treated with renin angiotensin blockade agents plus other hypertensive drugs when needed.METHODS:One hundred fifteen patients [median age 52 years(68% males)] were consequently enrolled in the study.For each patient,we recorded gender,age,body mass index(BMI),peripheral systolic blood pressure(p SBP),peripheral diastolic blood pressure,peripheral pulse pressure,central systolic blood pressure(c SBP),central diastolic blood pressure(c DBP),central pulse pressure(c PP),hematocrit,hemoglobin,hs CRP,total cholesterol triglycerides,high-density lipoprotein-C,low-density lipoprotein-C,calcium,phosphorus,parathormone,and albumin,as well as 24 h urine albumin excretion.According to 24-h urine albumin collection,patients were then classified as those with moderately increased albuminuria(formerly called macroalbuminuria)(≤ 300 mg/d) and those with severely increased albuminuria(formerly called macroaluminuria(> 300 mg/d).We considered aortic stiffness(AS) indices [carotid femoral pulse wave velocity(PWVc-f) and augmentation index(AIx)] as primary outcomes ofthe study.We explored potential correlations between severely increased albuminuria and AS indices using a multiple linear regression model.RESULTS:Fifty-eight patients were included in the moderately increased albuminuria group and 57 in the severely increased albuminuria.Blood pressure measurements of the study population were 138 ± 14/82 ± 1.3 mm Hg(systolic/diastolic).There were no significant differences in age,sex,and BP measurements between the two groups.Patients with severely increased albuminuria had higher PWV and AIx than patients with moderately increased albuminuria(P < 0.02,P < 0.004,respectively).In addition these patients exhibited higher BMI(P < 0.03),hs CRP(P < 0.001),and fibrinogen levels(P < 0.02) compared to patients with moderately increased albuminuria.In multivariate linear regression analysis,severely increased albuminuria(β = 1.038,P < 0.010) p SBP(β = 0.028,P < 0.034) and Ht(β = 0.171,P = 0.001) remained independent determinants of the increased PWVc-f.Similarly,severely increased albuminuria(β = 4.385,P < 0.012),c SBP(β = 0.242,P < 0.001),c PP(β = 0.147,P < 0.01) and Ht levels(β = 0.591,P < 0.013) remained independent determinants of increased AIx.CONCLUSION:These findings demonstrate an independent association between AS indices and severely increased albuminuria in non-diabetic,hypertensive patients with CKD stages 1-2 treated with renin angiotensin aldosterone system blockers. | Rigas G Kalaitzidis Despina P Karasavvidou Athina Tatsioni Kosmas Pappas Giorgos Katatsis Angelos Liontos Moses S Elisaf | 2015 | World Journal of Nephrology2015，4，3： | 5 |
| 2 | Transcriptome analyses of the Dof-like gene family in grapevine reveal its involvement in berry, flower and seed development显示文摘The Dof(DNA-binding with one finger)protein family spans a group of plant transcription factors involved in the regulation of several functions,such as plant responses to stress,hormones and light,phytochrome signaling and seed germination.Here we describe the Dof-like gene family in grapevine(Vitis vinifera L.),which consists of 25 genes coding for Dof.An extensive in silico characterization of the VviDofL gene family was performed.Additionally,the expression of the entire gene family was assessed in 54 grapevine tissues and organs using an integrated approach with microarray(cv Corvina)and real-time PCR(cv Pinot Noir)analyses.The phylogenetic analysis comparing grapevine sequences with those of Arabidopsis,tomato,poplar and already described Dof genes in other species allowed us to identify several duplicated genes.The diversification of grapevine DofL genes during evolution likely resulted in a broader range of biological roles.Furthermore,distinct expression patterns were identified between samples analyzed,corroborating such hypothesis.Our expression results indicate that several VviDofL genes perform their functional roles mainly during flower,berry and seed development,highlighting their importance for grapevine growth and production.The identification of similar expression profiles between both approaches strongly suggests that these genes have important regulatory roles that are evolutionally conserved between grapevine cvs Corvina and Pinot Noir. | Danielle Costenaro da Silva Vítor da Silveira Falavigna Marianna Fasoli Vanessa Buffon Diogo Denardi Porto Georgios Joannis Pappas Jr Mario Pezzotti Giancarlo Pasquali Luís Fernando Revers | 2016 | Horticulture Research2016，3，1： | 5 |
| 3 | Some experiences with the eigensystem realization algorithm 显示文摘 | Pappa R S Juang J N | 1988 | Sound and Vibration1988，22，1： | 1 |
| 4 | An eigensystem realization algorithm for modal parameter identification and model reduction 显示文摘 | Juang J N Pappa R S | 1985 | J Guidance Control and Dynamics1985，8，5： | 1 |
| 5 | Improved genome annotation for Zymomonasmobilis 显示文摘 | Yang S Pappas KM Hauser LJ Land ML Chen GL Hurst GB PanC Kouvelis VN Typas MA Pelletier DA Klinqeman DM Chanq YJ Samatova NF Brown SD | 2009 | Nat Biotechnol2009，27，10： | 1 |
| 6 | An eigensystem realization algorithm for modal parameter identification and model reduction显示文摘 | Juang J N Pappa R S | 1985 | Journal of Guidance Control and Dynamics1985，8，5： | 1 |
| 7 | A Parametric study of the Ibrahim Time Doamin Modal Identification Algorithm 显示文摘 | Pappa R S Ibrahim S R | 1980 | Shock & Vibration Bulletin1980，51，3： | 1 |
| 8 | Percutaneous management of u- reteral stenosis of transplanted kidney : technical and clinical aspects 显示文摘 | Leonardou P Gioldasi S Pappas P | 2011 | Urol Int2011，87，4： | 1 |
| 9 | VEGF increases permea- bility of the endothelial cell monolayer by activation of PKB/ akt, endothelial nitric-oxide synthase, and MAP kinase path- ways显示文摘 | Lal BK Varma S Pappas P J | 2001 | Microvasc Res2001，62，3： | 1 |
| 10 | The multidrug resistance 1 gene Abcbl in brain and placenta: comparative analysis in human and guinea pig显示文摘 | Pappas J J Petropoulos S Suderman M | 2014 | Plos One2014，29，11： | 1 |
| 11 | Impro vement of biodiesel production based on the application of ultrasound: Monitoring of the procedure by FTIR spectroscopy显示文摘 | Siatis N G Kimbaris A C Pappas C S | 2006 | JAOCS2006，83，1： | 1 |
| 12 | Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma显示文摘 | Alexandrakis MG Pappa CA Miyakis S | 2006 | Eur J Intern Med2006，17，6： | 1 |
| 13 | An Eigen system Realization Algorithm (ERA) for modal parameter identification and model reduction 显示文摘 | Juang J N Pappa R S | 1985 | Guidance Control and Dynamics1985，8，5： | 1 |
| 14 | Large modal survey testing using the ibrahim time domain (ITD) identification technique显示文摘 | Ibrahim S R Pappa R S | 1981 | AIAA1981，22，2： | 1 |
| 15 | Monoclonal gammopathies in B-cell non-Hodgkin's lymphomas显示文摘 | Economopoulos T Papageorgiou S Pappa V | 2003 | Leuk Res2003，27，6： | 1 |
| 16 | An eigensystem realization algorithm for modal parameter identification and model reduction 显示文摘 | Juang J N Pappa R S | 1985 | Journal of Guidance Control and Dynamics1985，8，： | 1 |
| 17 | An Eigensystem Realization Algorithm for Modal Parameter Identification and Model Reduction 显示文摘 | Juang J N Pappa R S | 1985 | Journal of Guidance Control and Dynamics1985，8，5： | 1 |
| 18 | The role of micro RNAs in normal and malignant -hematopoiesis显示文摘 | Vasilatou D Papageorgiou S Pappa V | 2010 | Eur J Haematol2010，84，1： | 1 |
| 19 | Childhoodoutcomes after hypothermia for neonatal encephalopathy 显示文摘 | Shankaran S Pappas A McDonald SA | 2012 | NEngl J Med2012，366，22： | 1 |
| 20 | Effect of entrained air voids on the microstructure and mass trans- port properties of concrete显示文摘 | WONG H S PAPPAS A M ZIMMERMAN R W | 2011 | Cement and Concrete Re- search2011，41，10： | 1 |
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