|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Cortically Coupled Computer Vision for Rapid Image Search显示文摘 | Parra L C Sajda P | 2006 | IEEE Transactions on Neural Systems and Rehabilitation Engineering2006，14，2： | 1 |
| 3 | Characterisation with stable isotopes of the presence of a lag phase in the gastric emptying of liquids显示文摘 | Gonzalez A Mugueta C Parra D | 2000 | Eur J Nutr2000，39，5： | 1 |
| 4 | Exposure to Volatile Organic Compounds(VOC) in Public Buses of Pamplona,Northern Span显示文摘 | Parra M A Elustondo D Bermejo R | 2008 | Science of The TotalEnvironment2008，，404： | 1 |
| 5 | An experimental study on pitch compensation in pedestrian-protection systems for collision avoidance and mitigation 显示文摘 | Llorca D R Sotelo M A Parra I | 2009 | IEEE Transactions on Intelligent Transportation Systems2009，10，3： | 1 |
| 6 | Influence of vegetable shortening and emulsifiers on the unfrozen water content and textural properties of frozen French bread dough显示文摘 | MATUDA T G PARRA D F LUGAO A B | 2005 | Lebensmittel Wissenschaft und Technologie2005，38，： | 1 |
| 7 | Rheic Ocean ophiolitic remnants in southern Ibeda questioned by SHRIMP U-Pb zircon ages on the Beja-Acebuches amphibolites显示文摘 | Azor A Rubatto D Simancas J.F González Lodeiro F Martínez Poyatos D Martín Parra L.M Matas J | | 0，，： | 1 |
| 8 | A diet rich in long chain omega 3 fatty acids modulates satiety in overweight and obese volunteers during weight loss显示文摘 | Parra D Ramel A Bandarra N | 2008 | Appetite2008，51，22： | 1 |
| 9 | Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine 显示文摘 | D′Aquila P Parra A | 1995 | Psychopharmacology1995，117，4： | 1 |
| 10 | Cardiac arrhythmias after subarachnoid hemorrhage:risk factors and impact on outcome显示文摘 | Frontera JA Parra A Shimbo D | 2008 | Cerebrovasc Dis2008，26，1： | 1 |
| 11 | Mechanical and microstructural investigation of friction spot welded AA6181-T4 aluminum alloy显示文摘 | ROSENDO T PARRA B TIER M A D | | 0，，： | 1 |
| 12 | Mechanical and micro- structual investigation of friction spot welded AA6181-T4 alumin- ium alloy显示文摘 | Rosenda T Parra B Tier M A D | 2011 | Materials & Dsign2011，32，3： | 1 |
| 13 | Using liposomes in wool chlorination:stability of chlorine liposomes and their application on wool fibers显示文摘 | Maza A D L A Parra J L Bosch P | 1991 | Textile Research Journal1991，61，6： | 1 |
| 14 | Autonomous pedestrian collision avoidance using a fuzzy steering controller 显示文摘 | FERNANDEZ L D MILANES V PARRA A I GAVILAN M GARCIA D I PEREZ J SOTELO M A | 2011 | IEEE Transactions on Intelligent Transportation Systems2011，12，： | 1 |
| 15 | Isolation,characterization,and molecular cloning of a specific Mycobacterium tuberculosis antigen:identification of a species-specific sequence 显示文摘 | Londono L P Portillo P D | 1991 | Infect Immun1991，59，： | 1 |
| 16 | In vivo assessment of the mitoehondrial response to caloric restriction in obese women by the 2- keto isocaproate breath test 显示文摘 | PARRA D GONZALEZ A MART | 2003 | Metabolism2003，52，4： | 1 |
| 17 | Influence of vegetable shortening and emulsifiers on the unfrozen water content and textural properties of frozen French bread dough显示文摘 | MATUDA T G PARRA D F LUGAO A B | 2005 | Lebensmittel Wissenschaft und Technologie2005，38，： | 1 |
| 18 | Robust visual odometry for vehicle localization in urban environments显示文摘 | Parra I Sotelo M A Llorca D F | 2010 | Robotica2010，28，3： | 1 |
| 19 | Destratification by mechanical mixers: Mixing efficiency and flow scaling显示文摘 | Hill D F Vergara A M Parra E J | 2008 | Journal of Hydraulic Engineering2008，134，12： | 1 |
| 20 | Laboratory approach to mitochondrial diseases显示文摘 | Parra D G onzález A Mugueta C | | 0，，03： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员