|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Monocyte chemoattractant protein-1, transforming growth factor-β1, nerve growth factor, resistin and hyaluronic acid as serum markers:comparison between recurrent acute and chronic pancreatitis显示文摘BACKGROUND: Diagnostic parameters that can predict the presence of chronic pancreatitis(CP) in patients with recurrent pain due to pancreatitis would help to direct appropriate therapy. This study aimed to compare the serum levels of monocyte chemoattractant protein-1(MCP-1), transforming growth factor-β1(TGF-β1), nerve growth factor(NGF), resistin and hyaluronic acid(HA) in patients with recurrent acute pancreatitis(RAP) and CP to assess their ability to differentiate the two conditions.METHODS: Levels of serum markers assessed by enzymelinked immunosorbent assay(ELISA) were prospectively compared in consecutive patients with RAP, CP and in controls and stepwise discriminant analysis was performed to identify the markers differentiating RAP from CP.RESULTS: One hundred and thirteen consecutive patients(RAP=32, CP=81) and 78 healthy controls were prospectively enrolled. The mean(SD) age of the patients was 32.0(14.0)years; 89(78.8%) were male. All markers were significantly higher in CP patients than in the controls(P<0.001); MCP-1NGF and HA were significantly higher in RAP patients than in the controls(P<0.001). Stepwise discriminant analysis showed significant difference(P=0.002) between RAP and CP for resistin with an accuracy of 61.9%, discriminant scores of ≤-0.479 and ≥0.189 indicating RAP and CP, respectively. The other markers had no differential value between RAP and CP.CONCLUSION: Serum resistin is a promising marker to differentiate between RAP and CP and needs validation in future studies, especially in those with early CP. | M Ganesh Kamath C Ganesh Pai Asha Kamath Annamma Kurien | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 7 |
| 2 | Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy显示文摘AIM To assess the outcomes of drug therapy(DT)followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis.METHODS DT comprised of pancreatic enzymes and antioxidants failing which,endotherapy(ET;pancreatic sphincterotomy and stent placement)was done.The frequency of pain,its visual analogue score(VAS),quality of life(Qo L),serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET.Response was defined as at least 50%reduction in the severity of pain to below a score of 5.RESULTS Of the thirty nine patients analysed,21(53.9%)responded to DT and 18(46.1%)underwent ET.The VAS for pain(7.0±2.0 vs 1.3±2.5,P<0.001)and the number of days with pain per month decreased[1.0(1.0,2.0)vs 1.0(0.0,1.0),P<0.001],and the Qo L scores[55.0(44.0,66.0)vs 38.0(32.00,51.00),P<0.01]improved significantly during follow up.Similar significant improvements were seen in patients in the subgroups of DT and ET except for Qo L in ET.The serum C-peptide(P=0.001)and FE(P<0.001)levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT.CONCLUSION A standardised protocol of DT,followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis,enhanced Qo L and improved pancreatic function. | C Ganesh Pai M Ganesh Kamath Mamatha V Shetty Annamma Kurien | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 3 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 4 | A new approach to dyna-mic security assessment using trajectory sensitivities显示文摘 | Laufenberg M J Pai M A | 1998 | IEEE Trans on Power Systems1998，13，3： | 1 |
| 5 | Surface roughness and its effects on the heat transfer mechanism in spray cooling 显示文摘 | Pais M R Chow L C Mathefdey E T | 1992 | ASME Journal of Heat Transfer1992，114，1： | 1 |
| 6 | Drug development against metas-tasis-related genes and their pathways:a rationale for cancertherapy显示文摘 | Iiizumi M Liu W Pai SK | 2008 | Biochim Biophys Acta2008，1786，2： | 1 |
| 7 | Trajectory sensitivity analysis of hybrid systems显示文摘 | Hiskens I A Pai M A | 2000 | IEEE Transactions on Circuits and Systems I2000，47，2： | 1 |
| 8 | Probabilistic assessment of regional mercury exposure显示文摘 | Seigneur C Pai P Gerath M | 1997 | Water air and soil pollution1997，97，： | 1 |
| 9 | A randomized,placebocontrolled,double-blind trial of ondanse-tron in renal itch显示文摘 | Murphy M Reaich D Pai P | 2003 | Br J Dermatol2003，148，2： | 1 |
| 10 | Gamma interferon release assays for detection of Mycobacterium tuberculosis infection显示文摘 | Pai M Denkinger CM Kik SV | 2014 | Clin Microbiol Rev2014，27，： | 1 |
| 11 | Radiofrequency assisted liver resection:Analysis of 604 consecutive cases显示文摘 | Pai M Frampton AE Mikhail S | 2012 | Eur J Surg Oncol2012，38，3： | 1 |
| 12 | The effects of inter-firm power and supply partner assessment on supply chain integra- tion显示文摘 | Pai F Y Yeh T M | 2010 | African Journal of Business Management2010，4，7： | 1 |
| 13 | Steady-state plasma pharmacokinetics of oral voricon- azole in obese adults显示文摘 | PAI M T P | 2011 | Antimicrob Agents Chemother2011，55，6： | 1 |
| 14 | The Canadian Hemophilia Registry as the basis for a national system for monitoring the use of factor concentrates显示文摘 | Walker I Pai M Akabatu B | 1995 | Transfusion1995，35，7： | 1 |
| 15 | 显示文摘 | Loureiro Jose M Rodrigues Alirio E | 1998 | Journal of Chromatography A1998，827，： | 1 |
| 16 | Comstock G Meta-analysis: New tests for the diagnosis of latent tuberculosis infection: Areas of uncertainty and recommendations for research显示文摘 | Menzies D Pai M | 2007 | Ann Intern Med2007，146，19： | 1 |
| 17 | The prognosis of latent tuberculosis: can disease be predicted? 显示文摘 | Anderden P Doherty T M Pai M | 2007 | Trends Mol Med2007，13，5： | 1 |
| 18 | Trajectory sensitivity analysis of hybrid systems显示文摘 | Hiskens I A pai M A | 2000 | IEEE Trans on Circuits and Systems2000，47，2： | 1 |
| 19 | Trajectory sensitivity analysis of hybrid systems显示文摘 | Hiskens I A Pai M A | 2000 | IEEE Trans on Circuits and Systems2000，47，2： | 1 |
| 20 | Molecular characterization of tiny ring X chromosomes from females with functional X chromosome disomy and lack of cis X inactivation显示文摘 | JANI M M TORCHIA B S PAI G S | 1995 | Genomics1995，27，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员