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| 1 | Design of a new dynamical core for global atmospheric models based on some efficient numerical methods显示文摘A careful study on the integral properties of the primitive hydrostatic balance equations for baroclinic atmosphere is carried out, and a new scheme todesign the global adiabatic model of atmospheric dynamics ispresented. This scheme includes a method of weighted equal-areamesh and a fully discrete finite difference method with quadraticand linear conservations for solving the primitive equationsystem. Using this scheme, we established a new dynamical corewith adjustable high resolution acceptable to the availablecomputer capability, which can be very stable without anyfiltering and smoothing. Especially, some important integralproperties are kept unchanged, such as the anti-symmetries of thehorizontal advection operators and the vertical convectionoperator, the mass conservation, the effective energy conservationunder the standard stratification approximation, and so on. Somenumerical tests on the new dynamical core, respectively regardingits global conservations and its integrated performances inclimatic modeling, incorporated with the physical packagesfrom the Community Atmospheric Model Version 2 (CAM2) of NationalCenter for Atmospheric Research (NCAR), are included. | WANG Bin, WAN Hui, Jl Zhongzhen, ZHANG Xin, YU Rucong, YU Yongqiang & LIU HongtaoState Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Computational Mathematics, Academy of Mathematics and System Sciences, Peking University, Beijing 100871, China | 2004 | Science China Mathematics2004，47，z1： | 92 |
| 2 | 应用20项新生儿行为神经测定预测窒息儿的预后显示文摘1989年1月~1991年12月全国13个单位协作研究新生儿20项行为神经测定(NBNA)于足月窒息儿的应用。145例中随访至1~2岁125例。结果显示:7天NBNA<35分36例中44.4%预后不良;12~14天NBNA<35分14例中78.6%预后不良,而>35分者98.3%正常。7天NBNA评分预测预后的敏感性和特异性分别为88,9%和82.6%,12~14天为84.6%和97.4%。其预测预后的价值优于Sarnat分度、头颅CT和B超。本方法实用、经济、可靠,值得推广。 | BaoXiu-lan YuRen-jie LiZhuo-suan(Department of Pediairics. Peking Unton Medical coliege Hospitol, Beijing 100730.) | 1994 | 中华儿科杂志1994，32，4： | 115 |
| 3 | 瑞舒伐他汀治疗中国高胆固醇血症患者疗效和安全性的随机双盲多中心对照研究显示文摘目的评价瑞舒伐他汀治疗中国高胆固醇血症患者的疗效和安全性。方法采用随机、双盲、多中心研究。患者经6周筛选后符合 LDL-C≥4.14 mmol/L(160 mg/dl),<6.50 mmol/L(250 mg/dl)、TG<4.52 mmol/L(400 mg/dl)者以2:1随机接受瑞舒伐他汀10 mg/d 或阿托伐他汀10mg/d 治疗。12周后瑞舒伐他汀组 LDL-C 未达到 ATPⅢ治疗目标者,予瑞舒伐他汀20 mg 延续治疗8周。结果 304例进入随机治疗阶段,瑞舒伐他汀10 mg/d 组201例,阿托伐他汀10 mg/d 组103例。意向治疗人群290例,符合方案人群263例。瑞舒伐他汀组治疗12周后血 LDL-C 显著下降,下降幅度为45.6%,显著大于阿托伐他汀组的39.0%(P<0.001)。瑞舒伐他汀组患者 LDL-C 达标率也较阿托伐他汀组(78.0%比72.7%)有增高趋势,且在高危人群中优势更为明显(56.5%比35.0%),但差异未达到统计学意义。瑞舒伐他汀降低 TG(-22.8%)以及升高 HDL-C(+6.6%)和ApoA-1(+12.5%)的幅度与阿托伐他汀组差别无统计学意义(分别为-16.6%,+4.3%和+9.8%)。29例患者接受20 mg/d 瑞舒伐他汀延续治疗,22例完成治疗患者中10例(45.5%)LDL-C达标。研究中未发现药物相关的严重不良反应事件。结论本组研究显示瑞舒伐他汀10 mg 降低LDL-C 的疗效优于同等剂量的阿托伐他汀,治疗3个月安全性与之类似。 | Rosuvastatin Registration Clinical Trial Group.Cardiovascular Institute and Fu Wai Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100037,China | 2007 | 中华心血管病杂志2007，35，3： | 117 |
| 4 | 我国面临快速增长的终末期肾病治疗负担显示文摘目的报告2008年我国终末期肾脏病维持性透析患病率和发病率,并估计未来维持性透析的趋势。方法中国医院协会血液净化中心管理分会制定调查表,以透析登记软件及纸质版形式下发至各省、自治区和直辖市的血液净化中心管理分会/血液净化质量控制中心,收集各透析室的数据,包括2007年底和2008年底患者数量,以及2008年新进入透析的患者数量;患者的性别和年龄构成;导致终末期肾脏病(ESRD)的原因以及所有死亡患者的原因。分析2007和2008年底ESRD的点患病率、2008年ESRD发病率、ESRD病因以及死亡原因构成。结果全国31个省、自治区和直辖市中,27个应答。2007年底,共报告65074例ESRD患者,点患病率为每百万人口51.7;2008年底患者数增至102863例,点患病率为每百万人口79.1,患病率增长52.9%。2008年ESRD新患者数为45423例,发病率每百万人口36.1。ESRD的病因依次为肾小球肾炎(45%)、糖尿病(19%)、高血压(13%)、多囊肾病(2%)和其他或未知(20%)。ESRD主要死亡原因是心血管疾病(31%)、中风(20.3%)、感染(19.9%)和其他(28.8%)。结论虽然我国ESRD的患病率显著低于其他亚洲国家和地区,但发病率极高,未来几年患病率也将快速增加,从而增加我国ESRD的治疗负担。 | Li Zuo M.D.1 and Mei Wang M.D.2 for Chinese Society of Blood Purification Institute of Nephrology,Peking University First 1 Hospital Institute of Nephrology,Peking University People’s Hospital 2 | 2010 | 中国血液净化2010，，1： | 145 |
| 5 | Biomass carbon stocks in China's forests between 2000 and 2050:A prediction based on forest biomass-age relationships显示文摘China's forests are characterized by young forest age,low carbon density and a large area of planted forests,and thus have high potential to act as carbon sinks in the future.Using China's national forest inventory data during 1994-1998 and 1999-2003,and direct field measurements,we investigated the relationships between forest biomass density and forest age for 36 major forest types.Statistical approaches and the predicted future forest area from the national forestry development plan were applied to estimate the potential of forest biomass carbon storage in China during 2000-2050.Under an assumption of continuous natural forest growth,China's existing forest biomass carbon(C) stock would increase from 5.86 Pg C(1 Pg=1015 g) in 1999-2003 to 10.23 Pg C in 2050,resulting in a total increase of 4.37 Pg C.Newly planted forests through afforestation and reforestation will sequestrate an additional 2.86 Pg C in biomass.Overall,China's forests will potentially act as a carbon sink for 7.23 Pg C during the period 2000-2050,with an average carbon sink of 0.14 Pg C yr-1.This suggests that China's forests will be a significant carbon sink in the next 50 years. | XU Bing,GUO ZhaoDi,PIAO ShiLong & FANG JingYun* Department of Ecology,College of Urban and Environmental Sciences,and Key Laboratory for Earth Surface Processes of the Ministry of Education,Peking University,Beijing 100871,China | 2010 | Science China(Life Sciences)2010，53，7： | 61 |
| 6 | Expression of vascular endothelial growth factor and its receptors KDR and Fit-1 in gastric cancer cells显示文摘AIM: The expression of vascular endothelial growth factor (VEGF) and its receptors KDR and Flt-1 by gastric carcinoma tissues and different gastric carcinoma cell lines was detected to elucidate the molecular mechanism of this growth factor in promoting tumor growth.METHODS: The expression of VEGF, Flt-1 and KDR was determined by reverse transcription-polymerase chain reaction (RT-PCR) in gastric cancer cell lines RF-1, RF-48,AGS-1, NCI-N87, NCI-SNU-1, NCI-SNU-5, NCI-SNU-16 and KATO-Ⅲ. The expression of Flt-1 and KDR in paraffinembedded specimens of gastric cancer was determined by immunohistochemistry. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to assess the role of VEGF in tumor cell proliferation.RESULTS: All 8 gastric cancer cell lines analyzed expressed VEGF121 and VEGF16s and six of them expressed both Flt-1 and KDR, while cell line NCI-SNU-5 expressed Flt-1 only and cell line KATOⅢ expressed neither Flt-1 nor KDR. The gastric carcinoma tissues expressed Flt-1 and KDR widely,with the positive rate of expression of Flt-1 and KDR being 84.6 % and 70 % respectively. The exogenous VEGF stimulated the growth of KDR-positive cell lines NCI-N87 and AGS-1 in a dose-dependent manner but exhibited no effect on the growth of KDR-negative cell line NCI-N87.CONCLUSION: VEGF and its receptors KDR and Flt-1 were expressed widely in gastric carcinoma cells and the VEGF stimulated KDR-positive tumor cell growth directly. These results suggest that VEGF may play a role in promoting tumor growth and metastasis by participating in both paracrine and autocrine pathways. | Hua Zhang Jian Wu Lin Meng Cheng-Chao Shou,Peking University School ofOncology,Beij ing Institute for Cancer Research,Beijing 100034,China | 2002 | World Journal of Gastroenterology2002，8，6： | 69 |
| 7 | Patterns of above-and belowground biomass allocation in China's grasslands:Evidence from individual-level observations显示文摘Above-and belowground biomass allocation not only influences growth of individual plants,but also influences vegetation structures and functions,and consequently impacts soil carbon input as well as terrestrial ecosystem carbon cycling.However,due to sampling difficulties,a considerable amount of uncertainty remains about the root:shoot ratio(R/S),a key parameter for models of terrestrial ecosystem carbon cycling.We investigated biomass allocation patterns across a broad spatial scale.We collected data on individual plant biomass and systematically sampled along a transect across the temperate grasslands in Inner Mongolia as well as in the alpine grasslands on the Tibetan Plateau.Our results indicated that the median of R/S for herbaceous species was 0.78 in China's grasslands as a whole.R/S was significantly higher in temperate grasslands than in alpine grasslands(0.84 vs.0.65).The slope of the allometric relationship between above-and belowground biomass was steeper for temperate grasslands than for alpine.Our results did not support the hypothesis that aboveground biomass scales isometrically with belowground biomass.The R/S in China's grasslands was not significantly correlated with mean annual temperature(MAT) or mean annual precipitation(MAP).Moreover,comparisons of our results with previous findings indicated a large difference between R/S data from individual plants and communities.This might be mainly caused by the underestimation of R/S at the individual level as a result of an inevitable loss of fine roots and the overestimation of R/S in community-level surveys due to grazing and difficulties in identifying dead roots.Our findings suggest that root biomass in grasslands tended to have been overestimated in previous reports of R/S. | WANG Liang*,NIU KeChang,YANG YuanHe & ZHOU Peng Department of Ecology,Key Laboratory for Earth Surface Processes of the Ministry of Education,Peking University,Beijing 100871,China. | 2010 | Science China(Life Sciences)2010，53，7： | 54 |
| 8 | Mobius Isoparametric Hypersurfaces in S^(n+1) with Two Distinct Principal Curvatures | Hai Zhong LI Department of Mathematics, Tsinghua University. Beijing 100084. P. R. China Hui Li LIU Department of Mathematics, Northeastern University. Shenyang 110000. P. R. China Chang Ping WANG Key Laboratory of Pure and Applied Mathematics, School of Mathematical Sciences. Peking University, Beijing 100871, P. R. China Guo Song ZHAO Department of Mathematics, Sichuan University, Chengdu 610064. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 53 |
| 9 | Kinematics and dynamics of the Mesozoic orogeny and late-orogenic extensional collapse in the Sino-Mongolian border areas显示文摘The Sino-Mongolian border areas underwent two important tectonic events during Mesozoic time after late Paleozoic orogeny: a late Triassic to earlier Jurassic contractional event that resulted in a large-scale south-vergent thrust during the orogeny and a late Jurassic-earlier Cretaceous extensional event in a north-south direction that formed a metamorphic core complex. The kinematic and dynamic analyses show that the thrust sheet moved southwards with a kinematic vorticity number of ca. -0.10 and sub-horizontal maximum compressive stress axis that belongs to a contraction-thickening shear. The upper plate of the late-orogenic detachment relatively moved in a 165°direction. The average kinematic vorticity in its earlier stage was 0.74 that belongs to simple shear dominated shearing and related to the maximum compressive stress axes dipping at ~66°, while the later average kinematic vorticity was ~0.55°that belongs to pure shear dominated shearing with sub-vertical maximum compressive stress axes. This suggests that the thrusting led to the crust thickened and the lower plate rocks that were originally located in the upper crust depressed through a brittle-ductile transition zone into the lower crust and became warmer. The heated rocks trended to uplift since their increasing volume and decreasing density while the loading of the upper-plate rocks increased due to the structural thickening. Under the combined effect of the loading and the thermal-uplifting, the ductile shear zone in between increased in its component of vertical pure shear. Once its pure-shear component exceeded its simple-shear one the ductile shear zone became an extension-thinned shear zone. This progressive transitional process reflects internal and essential temporal and spatial relationships: the extensional factor nucleated during the crust thickening by thrusting and increase of the extensional factor finally led to late-orogenic collapse. | ZHENG Yadong 1 & WANG Tao2 1. Key Laboratory of Orogenic Belts and Crustal Evolution (Peking University), Ministry of Education, Beijing 100871, China 2. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，7： | 38 |
| 10 | Ultrahigh pressure (>7 GPa) gneissic K-feldspar (-bearing) garnet clinopyroxenite in the Altyn Tagh, NW China: Evi- dence from clinopyroxene exsolution in garnet显示文摘The exsolution of clinopyroxene and rutile in coarse-grain garnet is found in the gneissic K-feldspar(-bearing) garnet clinopyroxenite from Yinggelisayi in the Altyn Tagh, NW China. The maximum content of the exsolved clinopyroxene in the garnet is up to >5% by volume. The reconstructed precursor garnet (Grt1) before exsolution has a maximum Si content of 3.061 per formula uint, being of supersilicic or majoritic garnet. The peak-stage metamorphic pressure of >7 GPa is estimated using the geobarometer for volume percentage of exsolved pyroxene in garnet and the Si-(Al+Cr) geobarometer for majoritic garnet, and the temperature of about 1000℃ using the ternary alkali-feldspar geothermometer and the experimental data of ilmen- ite-magnetite solid solution. The protoliths of the rocks are intra-plate basic and intermediate ig- neous rocks, of which the geochemical features indicate that they are probably the products of the evolution of basic magma deriving from the continental lithosphere mantle. The rocks are in outcrops associated with ultrahigh pressure garnet-bearing lherzolite and ultrahigh pressure garnet granitoid gneiss. All of these data suggest that the ultrahigh pressure metamorphic rocks in the Altyn Tagh are the products of deep-subduction of the continental crust, and such deep- subduction probably reaches to >200 km in depth. This may provide new evidence for further discussion of the dynamic mechanism of the formation and evolvement of the Altyn Tagh and the other collision orogenic belts in western China. | LIU Liang1,3, CHEN Danling1, ZHANG Anda1, SUN Yong1, WANG Yan1, YANG Jiaxi1,2 & LUO Jinhai1 1. Key Laboratory of Continental Dynamics of the Ministry of Education of China, Northwest University, Xi’an 710069, China 2. College of Earth Science and Land Resources, Chang’an University, Xi’an 710054, China 3. The Laboratory of Orogen and Basin of the Ministry of Education, Peking University, Beijing 100871, China | 2005 | Science China Earth Sciences2005，48，7： | 38 |
| 11 | Optimization of the head shape of the CRH3 high speed train显示文摘Aiming at optimizing the head shape of the CRH3 high speed train, an efficient optimization approach is proposed. The CFD analysis by solving Navier-Stokes equations is coupled with optimization calculation based on the multi-objective genetic algorithm, meanwhile the arbitrary shape deformation technique (ASD) is also introduced into the design flow, which greatly shortens the time consumption for geometry regeneration and flow field remeshing. As a result, the efficiency of the optimization calculation is highly improved. Statistical analysis is done to the designs in the design space, and the correlation between the design variables and the objective is studied to find out the key variables that most affect the objective. Response surface analysis is also performed to get the nonlinear relationship between the key design variables and the objective with the Kriging algorithm. Finally, after the optimization, an aerodynamic performance comparison between the optimal shape and the original shape reveals that the original shape of CRH3 high speed train owns a very stable aerodynamic performance and can be trustingly used in industry. | SUN ZhenXu1, SONG JingJing1 & AN YiRan1 College of Engineering, State Key Laboratory for Turbulence and Complex Systems, Peking University, Beijing 100871, China | 2010 | Science China(Technological Sciences)2010，53，12： | 35 |
| 12 | The^(40)Ar/^(39)Ar age record of formation and uplift of the blueschists and eclogites in the western Tianshan Mountains显示文摘The 40Ar/39Ar ages indicate that the eclogite facies rocks of the Hasiate slice in the western Tianshan Mountains were formed at the early stage of Devonian (401 Ma) and had been uplifted to the greenschist facies tectonic level in the middle stage of Devonian (381 Ma). The formation and uplift of the blueschists of the Akesayi slice are constrained to the late stage of Devonian (370-364 Ma). The different tectonic slices in the high-pressure metamorphic belt have experienced the different uplift history. | GAO Jun, ZHANG Lifei & LIU Shengwei1. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 2. Department of Geology, Peking University, Beijing 100871, Chin | 2000 | Chinese Science Bulletin2000，45，11： | 35 |
| 13 | Structural pattern of eastern Himalayan syntaxis in Namjagbarwa and its formation process显示文摘The structural pattern of the eastern Himalayan syntaxis in Namjagbarwa consists of two series of structures with different styles. One series compiles the earlier ductile contractional and lateral-slip deformation system, formed by nearly north-south shortening within the syntaxis, left-lateral and right-lateral slipping along its western and eastern boundaries respectively. They were possibly produced by the indentation of the Indian continent into Asian continent after India-Asia collision. The peak deformation-metamorphic ages in these structures are 62-60 Ma, ~23 Ma and ~13 Ma. The other series is composed of ductile-brittle normal faults distributing concentrically and dipping toward the outsides of Namjagbarwa Peak. They were probably the collapse structures caused by rapid uplift in a later time and the beginning ages for the normal faulting are about 7.3-6.3 Ma. | ZHANG Jinjiang, Jl Jianqing, ZHONG Dalai, DING Lin & HE Shundong1. Department of Geology, Peking University, Beijing 100871, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Correspondence should be addressed to Zhang Jinjiang (email: zhjj@pku.edu.cn) | 2004 | Science China Earth Sciences2004，47，2： | 34 |
| 14 | An Archean continental block in the Taihangshan and Hengshan regions: Constraints from geochronology and geochemistry显示文摘Recent research on the tectonothermal evolution and geochronology in the Fuping, Hengshan and Wutaishan metamorphic complexes, together with the discoveries of a high-pressure granulite belt in the northern margin of the North China Craton (NCC) and high-pressure metapelites in the Jingangku Group of the Wutaishan complex, suggests that there was a Neoarchean to Paleoproterozoic orogenic belt related to collision between the Eastern and Western continental blocks. Comparison of geological, geochronological, tectonothermal and geochemical data between the Fuping and Hengshan complexes suggests these two complexes most likely originated and evolved as a single lithotectonic domain (i.e., the Taihangshan-Hengshan block) during the early evolution of the North China Craton, probably as an active margin to the Eastern Continental Block. The Taihangshan-Hengshan block has been subjected to intensive and extensive tectono-magmatism and high-grade metamorphism related to collision between the Eastern and Western continental blocks at ~1.80 Ga. | LIU Shuwen , LI Jianghai, PAN Yuanming, ZHANG Jian and LI Qiugen(1. The Key Laboratory of Orogenic Belts and Crustal Evolution, School of Earth and Space Sciences, Peking University, Beijing 100871, China 2. Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada) | 2002 | Progress in Natural Science:Materials International2002，12，8： | 32 |
| 15 | Assessment of candidate plant DNA barcodes using the Rutaceae family显示文摘DNA barcoding is a rapidly developing frontier technology that is gaining worldwide attention.Here,seven regions (psbA-trnH,matK,ycf5,rpoC1,rbcL,ITS2,and ITS) with potential for use as DNA barcodes were tested for their ability to identify 300 samples of 192 species from 72 genera of the family Rutaceae.To evaluate each barcode’s utility for species authentication,PCR amplification efficiency,genetic divergence,and barcoding gaps were assessed.We found that the ITS2 region exhibited the highest inter-specific divergence,and that this was significantly higher than the intra-specific variation in the 'DNA barcoding gap' assessment and Wilcoxon two-sample tests.The ITS2 locus had the highest identification efficiency among all tested regions.In a previous study,we found that ITS2 was able to discriminate a wide range of plant taxa,and here we confirmed that ITS2 was also able to discriminate a number of closely related species.Therefore,we propose that ITS2 is a promising candidate barcode for plant species identification. | LUO Kun1,2,CHEN ShiLin1,CHEN KeLi2,SONG JingYuan1,YAO Hui1,MA XinYe1,ZHU YingJie3,PANG XiaoHui1,YU Hua1,LI XiWen1,4 & LIU Zhen2 1Institute of Medicinal Plant Development,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100193,China 2College of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430061,China 3School of Bioscience and Engineering,Southwest Jiaotong University,Chengdu 610031,China 4Department of Chemistry,Tsinghua University,Beijing 100084,China | 2010 | Science China(Life Sciences)2010，53，6： | 32 |
| 16 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 17 | Technical framework for Internetware: An architecture centric approach显示文摘Being a new software paradigm evolved by the Internet, Internetware brings many challenges to the traditional software methods and techniques. Sponsored by the national basic research program (973), researchers in China have developed an architecture centric technical framework for the definition, incarnation and engineering of Internetware. First of all, a software model for Internetware is defined for what to be, including that Internetware entities should be packaged as components, behaving as agents, interoperating as services, collaborating in a structured and on demand manner, etc. Secondly, a middleware for Internetware is designed and implemented for how to be, including that Internetware entities are incarnated by runtime containers, structured collaborations are enabled by runtime software architecture, Internetware can be managed in a reflective and autonomic manner, etc. Thirdly, an engineering methodology for Internetware is proposed for how to do, including the way to develop Internetware entities and their collaborations by transforming and refining a set of software architectures which cover all the phases of software lifecycle, the way to identify and organize the disordered software assets by domain modeling, etc. | YANG FuQing1,2, Lü Jian3,4 & MEI Hong1,2 1 Key Laboratory of High Confidence Software Technologies (Peking University), Ministry of Education, Beijing 100871, China 2 School of Electronics Engineering and Computer Science, Peking University, Beijing 100871, China 3 State Key Laboratory for Novel Software Technology, Nanjing 210093, China 4 Department of Computer Science and Technology, Nanjing University, Nanjing 210093, China | 2008 | Science in China(Series F)2008，51，6： | 33 |
| 18 | Above-and belowground biomass in relation to envi- ronmental factors in temperate grasslands, Inner Mongolia显示文摘Above- and belowground biomasses of grasslands are important parameters for characterizing re- gional and global carbon cycles in grassland ecosystems. Compared with the relatively detailed in- formation for aboveground biomass (AGB), belowground biomass (BGB) is poorly reported at the re- gional scales. The present study, based on a total of 113 sampling sites in temperate grassland of the Inner Mongolia, investigated regional distribution patterns of AGB, BGB, vertical distribution of roots, and their relationships with environmental factors. AGB and BGB increased from the southwest to the northeast of the study region. The largest biomass occurred in meadow steppe, with mean AGB and BGB of 196.7 and 1385.2 g/m2, respectively; while the lowest biomass occurred in desert steppe, with an AGB of 56.6 g/m2 and a BGB of 301.0 g/m2. In addition, about 47% of root biomass was distributed in the top 10 cm soil. Further statistical analysis indicated that precipitation was the primary determinant factor in shaping these distribution patterns. Vertical distribution of roots was significantly affected by precipitation, while the effects of soil texture and grassland types were weak. | MA WenHong1,2, YANG YuanHe1, HE JinSheng1, ZENG Hui1,2 & FANG JingYun1 1 Department of Ecology, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China 2 School of Environment & Urban Study, Peking University Shenzhen Graduate School, Shenzhen 518055, China | 2008 | Science China(Life Sciences)2008，51，3： | 34 |
| 19 | The abnormal expression of retinoic acid receptor-β,p53 and Ki67 protein,n normal,premalignant and malignant esophageal tissues显示文摘AIM: Esophageal cancer remains a significant healthiproblem worldwide. It is important to investigate alterationsin expression of retinoic acid receptor-β, p53 and Ki67proteins in esophageal carcinogenesis.METHODS: To find biomarkers for early identification ofesophageal cancer, we analyzed the retinoic acid receptor-j3,p53 protein and the proliferation marker Ki67 in surgicalspecimens of normal, mildly, and severely dysplastic andmalignant esophageal tissues by in situ hybridization ofRNA and immunohistochemistry.RESULTS: RAR-β was expressed in 94.3 %(33/35) of normalmucosae, 67.8 %(19/28) of the mild, 58.1% (18/31) of thesevere ieaions and 53.2 % (116/218) of tumor samples. RAR-β mRNA was expressed in 62.7 % (42/67), 55.1% (43/78) and29.2 % (7/24) of well, moderated and poorly differentiatedSSCs. The p53 and Ki67 proteins were 5.9 % (2/34) of thenormal mucosa. P53 and Ki67 stained positively in 10.7 % (3/28) and 21.4 % (6/28) of mild dysplasia, and 51.6 %(16/31)and 58. 1% (18/31) of severely dysplasia respectively.Samples from esophageal cancer showed no higher levers ofp53 and Ki67 expression than seen in severely dysplasticlesions. There was significant difference of RAR-β、 p53 andKi67 expression between normal mucosa and dysplatictissue or esophageal cancer.CONCLUSION: Loss of RAR-β expression and acctnulation ofp53 and Ki67 proteins may serve as biomarkers for earlyidentification of esophageal cancer in the high-riskpopulations. | Min Xu Sheng-Zu Chen,Department of Nuclear Medcine,Cancer Hospital(Institute),Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 10002,1,China Yu-Lan Jin Jun Fu Hong Huang Ping Qu Hai-Mei Tian ZhaoYang Liu Wei Zhang,Central Laboratory for Tumor Biology,Cancer Hospital(Institute),Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100021,China | 2002 | World Journal of Gastroenterology2002，8，2： | 34 |
| 20 | Inhibiting Effects of Achyranthes Bidentata Polysaccharide and Lycium Barbarum Polysaccharide on Nonenzyme Glycation in D-galactose Induced Mouse Aging Model显示文摘To investigate the inhibiting effects and mechanism of achyranthes bidentata polysaccharide (ABP) and lycium barbarum polysaccharide (LBP) on nonenzyme glycation in D-galactose induced mouse aging model. Methods Serum AGE levels were determined by AGE-ELISA, MTT method was used to determine lymphocyte proliferation, IL-2 activity was determined by a bioassay method. Spontaneous motor activity was used to detect mouse's neuromuscular movement, latency of step-through method was used to examine learning and memory abilities of mouse, colormetric assay was used to determine hydroxyproline concentration in mouse skin, pyrogallol autoxidation method was used to determine superoxide dismutase (SOD) activity of erythrocytes. Results Decreased levels of serum AGE, hydroxyproline concentration in mouse skin and spontaneous motor activity in D-galactose mouse aging model were detected after treated with ABP or LBP, while lymphocyte proliferation and IL-2 activity, learning and memory abilities,SOD activity of erythrocytes, were enhanced. Conclusions ABP and LBP could inhibit nonenzyme glycation in D-galactose induced mouse aging model in vivo and ABP has a better inhibiting effect than LBP. | HONG-BIN DENG, DA-PENG CUI, JIAN-MING JIANG, YAN-CHUN FENG,NIAN-SHENG CAI, AND DIAN-DONG LIInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China | 2003 | Biomedical and Environmental Sciences2003，16，3： | 33 |
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